Protein Information

Name transferase
Synonyms 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
11166672 Anguiano OL, Caballero de Castro A, Pechen de D'Angelo AM: The role of glutathion conjugation in the regulation of early toad embryos' tolerance to pesticides. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Jan;128(1):35-43.

Reduced glutathion (GSH) content and glutathione S-transferase (GSH S-transferase) activity were investigated in developing toad embryos exposed to parathion, malathion, lindane and dieldrin.
33(0,1,1,3) Details
15612566 Taskin V, Kence M: The genetic basis of malathion resistance in housefly (Musca domestica L.) strains from Turkey. Genetika. 2004 Nov;40(11):1475-82.

In addition, we checked the malathion carboxylesterase (MCE), percent remaining activities in acetylcholinesterase (AChE), glutathion-S-transferase (GST), and general esterase activities in all 5 strains used in this study.
6(0,0,1,1) Details
2571067 Sergieva VP, Gracheva GV, Iasokevich VV: [The level and nature of insecticide resistance (DDT and malathion) in laboratory-strain mosquitoes]. Med Parazitol. 1989 May-Jun;(3):64-8.

Other strains featured various levels of DDT-resistance due to various mechanisms: in Ae. aegypti it was due to mixed-function oxidases activity; in An. atroparvus, An. sacharovi and An. stephensi second strain to glutathione-dependent transferase, in C. pipiens, An stephensi third strain and, partially, An. sacharovi,--to the probable presence of kdr-factor.
1(0,0,0,1) Details
2430350 Kashyap SK: Health surveillance and biological monitoring of pesticide formulators in India. Toxicol Lett. 1986 Oct;33(1-3):107-14.

Exposure of 160 workers to a combination of pesticides (malathion, parathion, DDT and HCH) resulted in 73% of the workers showing toxic signs and symptoms.
Changes in the liver enzymes ornithine carbamyl transferase (OCT), gamma-glutamyl transpeptidase (GGTP), leucine aminopeptidase (LAP) and in immunoglobulin M (IgM) showed possible effects on liver and humoral immunity.
1(0,0,0,1) Details
7138493 Wool D, Noiman S, Manheim O, Cohen E: Malathion resistance in Tribolium strains and their hybrids: inheritance patterns and possible enzymatic mechanisms (Coleoptera, Tenebrionidae). Biochem Genet. 1982 Aug;20(7-8):621-36.

A higher level of GSH transferase in the Kano x bb hybrids than in Kano seems to indicate a possible biochemical mechanism for their overdominant resistance.
1(0,0,0,1) Details
19603180 Yu Q, Abdallah I, Han H, Owen M, Powles S: Distinct non-target site mechanisms endow resistance to glyphosate, ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep;230(4):713-23. Epub 2009 Jul 15.


By using the cytochrome P450 inhibitor malathion and amitrole with ALS and ACCase herbicides, respectively, we showed that malathion reverses chlorsulfuron resistance and amitrole reverses diclofop resistance in the R population examined.
0(0,0,0,0) Details