Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
1761796 Pala I, Vig PJ, Desaiah D, Srinivasan A: In vitro effects of organophosphorus compounds on calmodulin activity. J Appl Toxicol. 1991 Dec;11(6):391-5.

In vitro effects of organophosphorus compounds (OP), such as malathion (M), methyl parathion (MP) and ethyl parathion (EP), on calmodulin (CaM) activity and its active conformation were studied to understand the mechanism (s) of neurotoxicity, since CaM is known to regulate Ca2+ transport and the enzymes involved in signal transduction and nucleotide metabolism.
34(0,1,1,4) Details
10234476 Rao MR, Kanji VK, Sekhar V: Pesticide induced changes of nitric oxide synthase in rat brain in vitro. Drug Chem Toxicol. 1999 May;22(2):411-20.

We measured NOS activity in rat brain in vitro in the presence of selected organic insecticides such as, 10-200 microM conc carbaryl, kepone and malathion.
We further demonstrated that these insecticides inhibit calmodulin (CaM)-stimulated NOS activity without affecting the basal enzyme activity.
1(0,0,0,1) Details