Protein Information

Name Ha ras
Synonyms C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
19787260 Calaf GM, Echiburu-Chau C, Roy D: Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes. Int J Oncol. 2009 Nov;35(5):1061-8.

It can be concluded that the organophosphorous pesticides parathion and malathion induced malignant transformation of breast cells through genomic instability altering p53 and c-Ha-ras, considered pivotal to cancer process.
9(0,0,1,4) Details
18204794 Calaf GM, Roy D: Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells. Int J Mol Med. 2008 Feb;21(2):261-8.

The c-Ha-ras oncogene was up-regulated by the effect of malathion alone and with the combination of estrogen and either malathion or parathion.
6(0,0,1,1) Details