Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
18722991 Elsheikha HM, Hussein HS, Rahbar MH: Clinico-pathological effects of Schistosoma mansoni infection associated with simultaneous exposure to malathion in Swiss outbred albino mice. Acta Trop. 2008 Oct;108(1):11-9. Epub 2008 Aug 3.

Alterations observed in infected, exposed mice included (i) higher mortality rate; (ii) severe pathologies in liver and spleen; (iii) increased serum level of bilirubin and alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes; (iv) decreased serum level of albumin and total proteins; and (v) decreased red blood cell count (RBC), lymphocytes, leucocytic count, and hemoglobin content.
1(0,0,0,1) Details
12020603 Seibert H, Morchel S, Gulden M: Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicol In Vitro. 2002 Jun;16(3):289-97.

Calculated molar ratios of substance bound to albumin ranged from 0.05 (arsenic trioxide) and 0.1 (potassium cyanide) to 2.5 and 4.7 moles/mole for malathion and xylene, respectively.
35(0,1,1,5) Details
1355942 Kolesnichenko IP, Dolgo-Saburova IS, Somova TV: [Changes in the biochemical composition of the cerebrospinal fluid in acute carbophos poisoning]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(2):95-9.

The purpose of the present study was to examine the nature of changes occurring in total protein and protein fractions, free amino acids (aspartic and glutamic acids, glycine, isoleucine, leucine) and in certain enzymes (AST, ALT, CP, GGTP, GDH) in the cerebrospinal fluid (CSF) of patients with acute Malathion insecticide poisoning. 137 patients aged 20 to 50 years were placed under observation.
The changes in protein fractions of the CSF are characterized by a fall of the content of globulins and a rise of albumins, thus attesting to the predominance of pathological processes in the brain, especially in the initial period of intoxication, and to the impairment of the blood-brain barrier.
1(0,0,0,1) Details
19941925 Kalender S, Uzun FG, Durak D, Demir F, Kalender Y: Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem Toxicol. 2010 Feb;48(2):633-8. Epub 2009 Nov 23.

0(0,0,0,0) Details
18484351 Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63.

As in vitro, dosing of rats with malathion did not result in significant albumin binding in vivo.
10(0,0,0,10) Details
12583686 Al-Qarawi AA, Adam SE: Effects of malathion plus superphosphate or urea on Najdi sheep. Vet Hum Toxicol. 2003 Feb;45(1):3-6.

Hepatonephropathy correlated with changes in serum AST, ALP, cholesterol, triglyceride, bilirubin, urea, total protein and albumin.
1(0,0,0,1) Details
8335887 Abou Zeid MM, el-Barouty G, Abdel-Reheim E, Blancato J, Dary C, el-Sebae AH, Saleh MA: Malathion disposition in dermally and orally treated rats and its impact on the blood serum acetylcholine esterase and protein profile. J Environ Sci Health B. 1993 Aug;28(4):413-30.

The FPLC integrated chromatograms proved an initiation of a new protein band accompanied with rearrangement of the albumin and pre-albumin bands.
1(0,0,0,1) Details
3590228 Keadtisuke S, Fukuto TR: Dysproteinuria induced in rats by O,O,S-trimethyl phosphorothioate. Toxicol Lett. 1987 Jun;37(1):33-9.

Administration of a single oral dose of 60 mg/kg O,O,S-trimethyl phosphorothioate (OOS-Me), a malathion impurity, resulted in a substantial increase in the amounts of amino acids along with a change in the nature of proteins excreted in the urine of treated rats.
In contrast to control rats, a small increase in albumin and a small decrease in alpha 1-globulin were observed.
1(0,0,0,1) Details