Protein Information

Name kininogen
Synonyms Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
8766249 Roland J, Soranzo L, Launay JM, Vargaftig B: [Demonstration of the immunoreactivity of polynuclear eosinophils for bombesin and substance P. Bull Acad Natl Med. 1996 Mar;180(3):697-706; discussion 706-8.

Eosinophil peroxidases (catalases) should not affect the immunocytochemical reaction, since heating during a paraplast embedding and sodium-azide in electron microscopy procedure destroyed these enzymes.
One of these epitopes is probably associated with the C-terminal sequence of B (with tachykinin-like activity) and seems to be present in other neuropeptides such as SP ; another epitope would be the N-terminal sequence of SP (with bradykinin-like activity).
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15190936 Baba SP, Patel DK, Bano B: Modification of sheep plasma kininogen by free radicals. Free Radic Res. 2004 Apr;38(4):393-403.

Aggregation and photoinactivation of HMWK was promoted by the substitution of H2O for deuterium oxide (D2O), which is known to prolong the life span of singlet oxygen, and suppressed by sodium azide a known singlet oxygen quencher.
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