| Name | lactoperoxidase |
|---|---|
| Synonyms | Airway lactoperoxidase; LPO; Lactoperoxidase; Lactoperoxidase precursor; SAPX; SPO; Salivary peroxidase; Lactoperoxidases… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8951230 | Oakley GG, Devanaboyina U, Robertson LW, Gupta RC: Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer. Chem Res Toxicol. 1996 Dec;9(8):1285-92. The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl (2) (849 and 896 8-oxodG/10 (6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10 (6) nucleotides, respectively). The incubation of 3,4-dichloro-2'5'-dihydroxybiphenyl (100 microM) with calf thymus DNA (300 micrograms/microL) in the presence of the breast tissue and milk-associated enzyme, lactoperoxidase (10 mU/mL), and H2O2 (0.5 mM) resulted in a significant increase in free radical-induced DNA damage (253 8-oxodG/10 (6) nucleotides) as compared to vehicle-treated DNA (118 8-oxodG/10 (6) nucleotides). |
2(0,0,0,2) | Details |
| 10193578 | Gutierrez-Correa J, Stoppani AO: Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, and thiol compounds. Free Radic Res. 1999 Feb;30(2):105-17. The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by and Similar effects were obtained with lactoperoxidase and horse-radish peroxidase supplemented systems. |
1(0,0,0,1) | Details |
| 17346675 | Herraiz T, Guillen H, Galisteo J: N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to beta-carbolinium cations by heme peroxidases. Biochem Biophys Res Commun. 2007 Apr 27;356(1):118-23. Epub 2007 Feb 26. However, 2-Me-THbetaC and 2,9-diMe-THbetaC were efficiently oxidized by horseradish peroxidase (HRP), lactoperoxidase (LPO), and myeloperoxidase (MPO) to 2-methyl-3,4-dihydro-beta-carbolinium cations (2-Me-DHbetaC (+), 2,9-diMe-DHbetaC (+)) as the main products, and detectable amount of 2-methyl-beta-carbolinium cations (2-Me-betaC (+), 2,9-diMe-betaC (+)). Peroxidase inhibitors sodium azide, and highly reduced or abolished this oxidation. |
1(0,0,0,1) | Details |
| 19825401 | Nasralla SN, Ghoneim AI, Khalifa AE, Gad MZ, Abdel-Naim AB: Lactoperoxidase catalyzes in vitro activation of acrylonitrile to . Toxicol Lett. 2009 Dec 15;191(2-3):347-52. Epub 2009 Oct 13. Free radical scavengers and trolox C), LPO enzyme inhibitor (resorcinol) and competitors for LPO binding (sodium azide and indomethacin) were found to reduce the rate of CN (-) production. |
1(0,0,0,1) | Details |
| 16429776 | Miyamoto A, Nakamura K, Ohba Y, Kishikawa N, Nakashima K, Kuroda N: Sequential injection analysis with chemiluminescence detection for the antioxidative activity against singlet Anal Sci. 2006 Jan;22(1):73-6. Lactoperoxidase- peroxide- ion system was used for the generation of (1) O2. |
1(0,0,0,1) | Details |
| 12616597 | Castro GD, Delgado de Layno AM, Costantini MH, Castro JA: Rat breast microsomal biotransformation of to but not to free radicals: its potential role in the association between drinking and breast tumor promotion. Teratog Carcinog Mutagen. 2003;Suppl 1:61-70. It is inhibited by diethyldithiocarbamate (DDTC), sodium azide, and diphenyleneiodonium (DPI) but not by desferrioxamine, which suggests a possible role of a non-iron -requiring flavoenzyme. |
0(0,0,0,0) | Details |