| Name | ATPDase |
|---|---|
| Synonyms | ATPDase; Hb6; ATPDase; CD39; CD39 antigen; Ecto ATP diphosphohydrolase; Ecto apyrase; Lymphoid cell activation antigen… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17095758 | Fausther M, Lecka J, Kukulski F, Levesque SA, Pelletier J, Zimmermann H, Dranoff JA, Sevigny J: Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G785-95. Epub 2006 Nov 9. The hepatic levels of extracellular nucleotides, and therefore the related downstream signaling cascades, are modulated by cell-surface enzymes called ectonucleotidases, including nucleoside diphosphohydrolase-1 (NTPDase1/CD39), NTPDase2/CD39L1, and ecto-5'-nucleotidase/CD73. |
6(0,0,0,6) | Details |
| 11113555 | Benrezzak O, Grondin G, Proulx J, Rousseau E, D'Orleans-Juste P, Beaudoin AR: Characterization and immunohistochemical localization of nucleoside diphosphohydrolase (NTPDase) in pig adrenal glands (presence of a non-sedimentable isoform). Biochim Biophys Acta. 2000 Dec 15;1524(2-3):94-101. Both ATPase and ADPase activities were similarly inhibited by sodium azide. |
83(1,1,1,3) | Details |
| 8673003 | Battastini AM, Oliveira EM, Moreira CM, Bonan CD, Sarkis JJ, Dias RD: Solubilization and characterization of an ATP diphosphohydrolase (EC 3.6.1.5) from rat brain synaptic plasma membranes. Biochem Mol Biol Int. 1995 Oct;37(2):209-19. Treatment of the synaptic plasma membrane from rat brain with 0.5% digitonin solubilizes 80% of the proteins and 50% and 60% of ATPase and ADPase, respectively, with the following characteristics: stimulation by Ca2+ in the millimolar range, insensitivity to ATPase inhibitors (ouabain, olygomicyn, orthovanadate), inhibition with sodium azide and NEM and broad substrate specificity for the hydrolysis of nucleoside di- and |
34(0,1,1,4) | Details |
| 11173996 | Zhang DX, Zou AP, Li PL: dilates bovine coronary small arteries through apyrase- and 5'-nucleotidase-mediated metabolism. J Vasc Res. 2001 Jan-Feb;38(1):64-72. This 5'-AMP accumulation was substantially inhibited by the apyrase inhibitor sodium azide (10 mmol/l). |
34(0,1,1,4) | Details |
| 10510290 | Benrezzak O, Grondin G, Sevigny J, Gendron FP, Rousseau E, D'Orleans-Juste P, Beaudoin AR: Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system. Arch Biochem Biophys. 1999 Oct 15;370(2):314-22. The parallel decrease in ATPase and ADPase activities, in the presence of sodium azide, indicated that an ATP diphosphohydrolase (ATPDase) was responsible for these activities. |
13(0,0,1,8) | Details |
| 10681547 | Sevigny J, Robson SC, Waelkens E, Csizmadia E, Smith RN, Lemmens R: Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase. J Biol Chem. 2000 Feb 25;275(8):5640-7. We have identified and characterized a novel ATP diphosphohydrolase (ATPDase) with features of E-type ATPases from porcine liver. Biochemical activity was unaffected by sodium azide or other inhibitors of ATPases. |
6(0,0,0,6) | Details |
| 10231536 | Smith TM, Lewis Carl SA, Kirley TL: Mutagenesis of two conserved residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase. Biochemistry. 1999 May 4;38(18):5849-57. |
6(0,0,0,6) | Details |
| 11498971 | Yi FX, Sun P, Huang SL, Liu WL, Guo ZG: Characteristics of apyrase (EC 3.6.1.5) on cultured bovine endocardial endothelial cells. Sheng Li Xue Bao. 1999 Aug;51(4):425-9. |
5(0,0,0,5) | Details |
| 12637029 | Demenis MA, Furriel RP, Leone FA: Characterization of an ectonucleoside triphosphate diphosphohydrolase 1 activity in alkaline phosphatase-depleted rat osseous plate membranes: possible functional involvement in the calcification process. Biochim Biophys Acta. 2003 Mar 21;1646(1-2):216-25. An ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) activity present in alkaline phosphatase-depleted rat osseous plate membranes, obtained 14 days after implantation of demineralized bone particles in the subcutaneous tissue of Wistar rats, was characterized. However, suramin and sodium azide were effective inhibitors of ATP and ADP hydrolysis. |
5(0,0,0,5) | Details |
| 8782093 | Caprino L, Togna AR, Stella C, Togna G: An in vitro method for evaluating vascular endothelial ADPase activity. J Pharmacol Toxicol Methods. 1996 Jun;35(3):153-7. |
5(0,0,0,5) | Details |
| 10678111 | Yi FX, Liu WL, Chen LW, Zeng S, Guo ZG: Hydrolysis of extracellular nucleotides by cultured bovine endocardial endothelial cells. Zhongguo Yao Li Xue Bao. 1999 Aug;20(8):745-9. AIM: To characterize the ATP diphosphohydrolase (apyrase) of bovine endocardial endothelial cells, and to compare ecto-adeninenucleotidase activity between bovine endocardial and aortic endothelial cells (BEEC and BAEC). |
5(0,0,0,5) | Details |
| 8031837 | Picher M, Beliveau R, Potier M, Savaria D, Rousseau E, Beaudoin AR: Demonstration of an ectoATP-diphosphohydrolase (E.C.3.6.1.5.) in non-vascular smooth muscles of the bovine trachea. Biochim Biophys Acta. 1994 Jul 6;1200(2):167-74. An ectoATP-diphosphohydrolase (ATPDase) is put in evidence in non-vascular smooth muscles of the bovine trachea. Sodium azide (20 mM), mercuric (10 microM) and gossypol (35 microM) inhibit the enzyme activity by more than 45%. |
4(0,0,0,4) | Details |
| 10836986 | Lemmens R, Kupers L, Sevigny J, Beaudoin AR, Grondin G, Kittel A, Waelkens E, Vanduffel L: Purification, characterization, and localization of an ATP diphosphohydrolase in porcine kidney. Am J Physiol Renal Physiol. 2000 Jun;278(6):F978-88. Partial purification of ATP diphosphohydrolase (ATPDase) was achieved by successive chromatography on concanavalin A-Sepharose, Q-Sepharose Fast Flow, and 5'-AMP-Sepharose 4B. All enzyme activities were dependent on divalent cations and were partially inhibited by 10 mM sodium azide. |
4(0,0,0,4) | Details |
| 9144325 | Menezes de Oliveira E, Oliveira Battastini AM, Meirelles MN, Menezes Moreira C, Dutra Dias R, Freitas Sarkis JJ: Characterization and localization of an ATP diphosphohydrolase activity (EC 3.6.1.5) in sarcolemmal membrane from rat heart. Mol Cell Biochem. 1997 May;170(1-2):115-23. In the present report we describe an ATP diphosphohydrolase (apyrase EC 3.6.1.5) in rat cardiac sarcolemma. Sodium azide that is a mitochondrial inhibitor at low concentrations, did not affect the enzyme activity at 5.0 mM or below. |
3(0,0,0,3) | Details |
| 15652174 | Leal DB, Streher CA, Neu TN, Bittencourt FP, Leal CA, da Silva JE, Morsch VM, Schetinger MR: Characterization of NTPDase (NTPDase1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5) activity in human lymphocytes. Biochim Biophys Acta. 2005 Jan 18;1721(1-3):9-15. Epub 2004 Oct 6. A significant inhibition of ATP and ADP hydrolysis (P <0.05) was observed in the presence of 20 mM sodium azide. |
3(0,0,0,3) | Details |
| 11403767 | de Aguiar Matos JA, Borges FP, Tasca T, Bogo MR, De Carli GA, da Graca Fauth M, Dias RD, Bonan CD: Characterisation of an ATP diphosphohydrolase (Apyrase, EC 3.6.1.5) activity in Trichomonas vaginalis. Int J Parasitol. 2001 Jun;31(8):770-5. It is Ca (2+)-dependent and is insensitive to classical ATPase inhibitors, such as ouabain (1 mM), N-ethylmaleimide (0.1 mM), orthovanadate (0.1 mM) and sodium azide (5 mM). |
3(0,0,0,3) | Details |
| 19922813 | Rosemberg DB, Rico EP, Langoni AS, Spinelli JT, Pereira TC, Dias RD, Souza DO, Bonan CD, Bogo MR: NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. Comp Biochem Physiol B Biochem Mol Biol. 2010 Mar;155(3):230-40. Epub 2009 Nov 14. Sodium azide (20mM), ARL 67156 (300 microM) and Suramin (300 microM) differently altered the nucleotide hydrolysis in zebrafish tissues, suggesting the contribution of distinct NTPDase activities. Homology-based searches identified the presence of NTPDase1-6 and NTPDase8 orthologs and the phylogeny also grouped three NTPDase2 and two NTPDase5 paralogs. |
2(0,0,0,2) | Details |
| 15979908 | Savegnago L, Nogueira CW, Fachinetto R, Rocha JB: Characterization of ATP and ADP hydrolysis activity in rat gastric mucosa. . Cell Biol Int. 2005 Jul;29(7):559-66. Sodium azide (0.03-30 mM), at high concentrations (> 0.1 mM), caused a parallel hydrolysis inhibition of ATP and ADP. Orthovanadate slightly inhibited (15%) Mg2+ and Ca2+ ATP/ADPase at 100 microM. |
2(0,0,0,2) | Details |
| 18201730 | Rucker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ: E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings. Life Sci. 2008 Feb 27;82(9-10):477-86. Epub 2008 Jan 16. RT-PCR analysis from left ventricle tissue demonstrate different levels of expression of Entpd1 (Cd39), Entpd2 (Cd39L1), Entpd3 (Cd39L3), Entpd5 (Cd39L4) Entpd6, (Cd39L2) and 5'-NT/CD73. Oligomycin (2 microg/mL) and sodium azide (0.1 mM), both mitochondrial ATPase inhibitors, inhibit only the ATP hydrolysis. |
1(0,0,0,1) | Details |
| 8720695 | Vrbjar N, Dzurba A, Ziegelhoffer A: Enzyme kinetics and the activation energy of Mg-ATPase in cardiac sarcolemma: ADP as an alternative substrate. Gen Physiol Biophys. 1995 Aug;14(4):313-21. Increasing concentrations of Mg within a range between 0.1-5.0 mmol/l step-by-step activated the Mg-dependent ATPase and ADPase in rat heart sarcolemma. |
1(0,0,0,1) | Details |
| 11862992 | Coimbra ES, Goncalves-da-Costa SC, Corte-Real S, De Freitas FG, Durao AC, Souza CS, Silva-Santos MI, Vasconcelos EG: Characterization and cytochemical localization of an ATP diphosphohydrolase from Leishmania amazonensis promastigotes. Parasitology. 2002 Feb;124(Pt 2):137-43. Sodium azide (5-10 mM) caused inhibition of the ATP and ADP hydrolysis in a dose-dependent manner. was the best activating metal ion for both ATPase and ADPase activities. |
1(0,0,0,1) | Details |
| 12899930 | Rico EP, Senger MR, Fauth Mda G, Dias RD, Bogo MR, Bonan CD: ATP and ADP hydrolysis in brain membranes of zebrafish (Danio rerio). Life Sci. 2003 Sep 5;73(16):2071-82. The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ATP diphosphohydrolase) in brain membranes of zebrafish (Danio rerio). It was able to hydrolyze and pyrimidine nucleosides 5'-di and triphosphates, being insensitive to classical ATPase inhibitors, such as ouabain (1 mM), N-ethylmaleimide (0.1 mM), orthovanadate (0.1 mM) and sodium azide (0.1 mM). |
1(0,0,0,1) | Details |
| 15050517 | Borges E, Cognato Gde P, Vuaden FC, Bogo MR, Fauth Mda G, Bonan CD, Dias RD: Nucleotidase activities in membrane preparations of nervous ganglia and digestive gland of the snail Helix aspersa. Comp Biochem Physiol B Biochem Mol Biol. 2004 Mar;137(3):297-307. ATPase and ADPase activities were dependent on Ca2+ and Mg2+ with pH optima approximately 7.2 and between 6.0 and 8.0 in digestive gland and nervous ganglia, respectively. Sodium azide, at 100 microM and 20 mM, inhibited Mg (2+)-ATP hydrolysis by 36% and 55% in digestive gland, respectively. |
1(0,0,0,1) | Details |
| 19016473 | Collins A, Larson MK: Kir 2.2 inward rectifier channels are inhibited by an endogenous factor in Xenopus oocytes independently from the action of a mitochondrial uncoupler. J Cell Physiol. 2009 Apr;219(1):8-13. We previously showed inhibition of K (ir) 2 inward rectifier K (+) channels expressed in Xenopus oocytes by the mitochondrial agents carbonyl p-trifluoromethoxyphenylhydrazone (FCCP) and sodium azide. |
0(0,0,0,0) | Details |