Protein Information

Name transferrin
Synonyms Beta 1 metal binding globulin; PRO1400; PRO1557; PRO2086; Serotransferrin; Serotransferrin precursor; Siderophilin; TF…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
9673237 Modun B, Evans RW, Joannou CL, Williams P: Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun. 1998 Aug;66(8):3591-6.

Metabolic poisons such as sodium azide and nigericin inhibited the release of iron from human transferrin, indicating that it is an energy-requiring process.
87(1,1,1,7) Details
16360136 Li YQ, Liu B, Zhao CG, Zhang W, Yang BS: Characterization of transferrin receptor-dependent GaC-Tf-FeN transport in human leukemic HL60 cells. Clin Chim Acta. 2006 Apr;366(1-2):225-32. Epub 2005 Dec 15.


BACKGROUND: Understanding the uptake of GaC-Tf-FeN by cells will provide key insights into studies on transferrin-mediated drug delivery.
2(0,0,0,2) Details
9186779 Richardson DR: Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process. Biochim Biophys Acta. 1997 May 16;1320(1):45-57.

Interestingly, the metabolic inhibitors, 2,4-dinitrophenol, oligomycin, rotenone, and sodium azide, markedly decreased 59Fe mobilization mediated by PIH, but had either no effect or much less effect on 59Fe release by 311.
Initial experiments examined the release of 59Fe from SK-N-MC neuroblastoma (NB) cells prelabelled for 3 h at 37 degrees C with 59Fe-transferrin (1.25 microM) and then reincubated in the presence and absence of the chelators for 3 h at 4 degrees C or 37 degrees C.
1(0,0,0,1) Details
7608173 Stockert RJ, Potvin B, Tao L, Stanley P, Wolkoff AW: Human hepatoma cell mutant defective in cell surface protein trafficking. J Biol Chem. 1995 Jul 7;270(27):16107-13.

Pretreatment with monensin, sodium azide, or colchicine reduced surface binding of 125I-ASOR in HuH-7 cells by 50% but had no effect on binding to Trf1 cells.
Binding of 125I-ASOR and 125I-transferrin was reduced in Trf1 cells to 49 +/- 2.5% and 30 +/- 2%, respectively, of HuH-7 cells.
1(0,0,0,1) Details
11771851 Lijnen P, Petrov V, Fagard R: In vitro assay of collagen gel contraction by cardiac fibroblasts in serum-free conditions. Methods Find Exp Clin Pharmacol. 2001 Sep;23(7):377-82.

The presence of insulin-transferrin-selenium in the medium caused a more pronounced stimulation of the collagen gel contraction by cardiac fibroblasts, while sodium azide inhibited this contraction.
31(0,1,1,1) Details