Protein Information

Name Hsp70
Synonyms APG 2; APG2; HS24/P52; HSP70RY; HSPA 4; HSPA4; Heat shock 70 kDa protein 4; Heat shock 70 related protein APG 2…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
10938586 Elez D, Vidovic S, Matic G: The influence of hyperthermic stress on the redox state of glucocorticoid receptor. Stress. 2000 May;3(3):247-55.


The results obtained show that the 41 degrees C stress leads to formation of intermolecular disulfide bonds between apo-GR and associated heat shock proteins (Hsp90, Hsp70).
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15389841 Barrett MJ, Alones V, Wang KX, Phan L, Swerdlow RH: Mitochondria-derived oxidative stress induces a heat shock protein response. J Neurosci Res. 2004 Nov 1;78(3):420-9.

We exposed human teratocarcinoma (NT2) cells to varying concentrations of the cytochrome oxidase inhibitor sodium azide.
Micromolar exposures resulted in a cytoplasm to nucleus translocation of the inducible Hsp70 and of Hsp40, and this was followed by an overall upregulation.
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12820649 Massie MR, Lapoczka EM, Boggs KD, Stine KE, White GE: Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans. Cell Stress Chaperones. 2003 Spring;8(1):1-7.

In addition, sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed enhanced Hsp70 expression, whereas Western blot analysis revealed the induction of Hsp16.
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11243411 Bailleul-Winslett PA, Newnam GP, Wegrzyn RD, Chernoff YO: An antiprion effect of the anticytoskeletal drug latrunculin A in yeast. Gene Expr. 2000;9(3):145-56.


On the other hand, treatments with sodium azide or cycloheximide, agents blocking yeast protein synthesis and cell proliferation but not disrupting the cytoskeleton, do not cause a significant loss of [PSI].
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