| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12854970 | El-Sayed IH, El-Masry SA: DNA strand scission by Fe (III) 2-methylaminopyridine complex and peroxide. Biotechnol Appl Biochem. 2003 Dec;38(Pt 3):253-6. The biological antioxidants such as sodium azide and superoxide dismutase significantly inhibited DNA breakage induced by [FeL2Cl2] Cl.H2O and peroxide. |
32(0,1,1,2) | Details |
| 9502580 | Hasegawa H, Suzuki K, Nakaji S, Sugawara K: Analysis and assessment of the capacity of neutrophils to produce reactive species in a 96-well microplate format using lucigenin- and luminol-dependent chemiluminescence. J Immunol Methods. 1997 Dec 15;210(1):1-10. Furthermore, we studied the contribution of various ROS to LgCL and luminol-dependent CL (LmCL) using modulators of ROS metabolism including superoxide dismutase (SOD), catalase, deferoxamine and sodium azide (NaN3). |
31(0,1,1,1) | Details |
| 9217305 | Hitzfeld B, Friedrichs KH, Ring J, Behrendt H: Airborne particulate matter modulates the production of reactive species in human polymorphonuclear granulocytes. Toxicology. 1997 Jul 11;120(3):185-95. The effects of the PM extracts were inhibited by superoxide dismutase (SOD), catalase and sodium azide (NaN3). |
31(0,1,1,1) | Details |
| 7861697 | Li JZ, Sharma R, Dileepan KN, Savin VJ: Polymorphonuclear leukocytes increase glomerular albumin permeability via hypohalous acid. Kidney Int. 1994 Oct;46(4):1025-30. This increase in Palbumin was inhibited by superoxide dismutase, catalase, or (Palbumin = 0.035 +/- 0.06, -0.39 +/- 0.10, 0.028 +/- 0.06, respectively) and ameliorated by sodium azide (Palbumin = 0.21 +/- 0.03). |
31(0,1,1,1) | Details |
| 9464485 | Okubo T, Nagai F, Ushiyama K, Yokoyama Y, Ozawa S, Kano K, Tomita S, Kubo H, Kano I: DNA cleavage and formation caused by tamoxifen derivatives in vitro. Cancer Lett. 1998 Jan 9;122(1-2):9-15. The DNA cleavage by N-desmethyltamoxifen was inhibited by the addition of EDTA, sodium azide, catalase and superoxide dismutase. |
31(0,1,1,1) | Details |
| 15271522 | Ferrer S, Ballesteros R, Sambartolome A, Gonzalez M, Alzuet G, Borras J, Liu M: Syntheses, crystal structures, and oxidative DNA cleavage of some Cu (II) complexes of 5-amino-3-pyridin-2-yl-1,2,4-triazole. J Inorg Biochem. 2004 Aug;98(8):1436-46. The influence on the DNA cleavage process of different scavengers of reactive species: (DMSO), tert- sodium azide, 2,2,6,6-tetramethyl-4-piperidone and superoxide dismutase enzyme (SOD), and of the minor groove binder distamycin, is also studied. |
31(0,1,1,1) | Details |
| 7638260 | Condorelli G, Constanzo LL, De Guidi G, Giuffrida S, Sortino S: Molecular mechanism of drug photosensitization. 7. Photochem Photobiol. 1995 Jul;62(1):155-61. On the basis of agarose gel electrophoresis data of samples irradiated in an air-saturated solution or in an -modified atmosphere, and the effects of sodium azide, D20, (II), superoxide dismutase, 2-H- deferoxamine and surfactants, we suggest a photosensitization mechanism involving singlet and free radicals. |
31(0,1,1,1) | Details |
| 8726583 | Sharov VS, Driomina ES, Vladimirov YA: Two processes responsible for chemiluminescence development in the course of iron-mediated lipid peroxidation. J Biolumin Chemilumin. 1996 Mar-Apr;11(2):91-8. SL amplitude was strongly inhibited by sodium azide (40%), superoxide dismutase (SOD) (30%), desferrioxamine and EDTA (30%), whereas and butylated hydroxytoluene were ineffective. |
31(0,1,1,1) | Details |
| 10619578 | Orie NN, Zidek W, Tepel M: Reactive species in essential hypertension and non-insulin-dependent diabetes mellitus. Am J Hypertens. 1999 Dec;12(12 Pt 1-2):1169-74. ROS was monitored with the dye, dihydrorhodamine-123 (DHR; 1 micromol/L) in the presence or absence of superoxide dismutase scavenger), sodium azide (singlet / peroxide scavenger), kinase inhibitor), or bisindolylmaleimide (protein kinase C inhibitor). |
31(0,1,1,1) | Details |
| 12123818 | Wang J, Xing D, He Y, Hu X: Experimental study on photodynamic diagnosis of cancer mediated by chemiluminescence probe. FEBS Lett. 2002 Jul 17;523(1-3):128-32. The chemiluminescence was markedly inhibited by the addition of 10 mmol/l sodium azide (NaN (3)) to the model solution and minor effects were observed at the addition of 10 micromol/l superoxide dismutase, 20 mmol/l and 100 microg/ml catalase, respectively, thus indicating that (1) O (2) generation from photosensitization reaction mainly results in light emission. |
31(0,1,1,1) | Details |
| 17197137 | Xia Q, Yin JJ, Fu PP, Boudreau MD: Photo-irradiation of Aloe vera by UVA--formation of free radicals, singlet and induction of lipid peroxidation. Toxicol Lett. 2007 Jan 30;168(2):165-75. Epub 2006 Dec 6. Superoxide dismutase and sodium azide inhibited and deuterium oxide enhanced the formation of lipid peroxides, suggesting that singlet and were involved in the mechanism. |
31(0,1,1,1) | Details |
| 10900404 | Vargas F, Mendez H, Tropper E, Velazquez M, Fraile G: Studies on the in vitro phototoxicity of the antidiabetes drug glipizide. . In Vitr Mol Toxicol. 2000 Spring;13(1):17-24. Inhibition of this process on addition of 1, 4-diazabicyclo [2.2.2] (DABCO), (GSH), sodium azide, superoxide dismutase, and confirmed the possibility of singlet ion and free radicals participation. |
31(0,1,1,1) | Details |
| 10926312 | Orie NN, Zidek W, Tepel M: Increased intracellular generation of reactive species in mononuclear leukocytes from patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 2000;108(3):175-80. Measurements were made in the presence or absence of superoxide dismutase, sodium azide, or bisindolylmaleimide 1. |
12(0,0,2,2) | Details |
| 14761423 | Jian L, Lang HQ: [The inhibitory effect of Lu-Duo-Wei on carbon disulfide-induced generation of Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Oct;21(5):368-71. OBJECTIVE: To study the scavenging effects of Lu-Duo-Wei, thiourea, superoxide dismutase, and sodium azide on carbon disulfide-induced generation of |
12(0,0,2,2) | Details |
| 9583081 | Takayama F, Egashira T, Yamanaka Y: [Assay for oxidative stress injury by detection of luminol-enhanced chemiluminescence in a freshly obtained blood sample: a study to follow the time course of oxidative injury]. Nippon Yakurigaku Zasshi. 1998 Mar;111(3):177-86. This CL was weakened slightly by superoxide dismutase and catalase, but markedly decreased by sodium azide. 2. |
6(0,0,1,1) | Details |
| 8675397 | Giangiacomo A, Olesen PR, Ortwerth BJ: and oxidation by ultraviolet A-generated free radicals. Invest Ophthalmol Vis Sci. 1996 Jul;37(8):1549-56. The role of individual reactive species was determined by the protective effects of superoxide dismutase, catalase, and sodium azide. |
6(0,0,1,1) | Details |
| 9491648 | Sharma M, Joshi PG, Joshi NB: Mechanism of photosensitization of glioblastoma and neuroblastoma cells by merocyanine 540: a lipid peroxidation study. Indian J Biochem Biophys. 1997 Aug;34(4):379-84. Photoinduced lipid peroxidation was measured in the presence of mechanistic probes-deuterium oxide (D2O), sodium azide, superoxide dismutase (SOD), and |
6(0,0,1,1) | Details |
| 7472809 | Giuffrida S, De Guidi G, Sortino S, Chillemi R, Costanzo LL, Condorelli G: Molecular mechanism of drug photosensitization. J Photochem Photobiol B. 1995 Aug;29(2-3):125-33. The comparison between the photohaemolysis and photolysis results and the effect of suitable additives such as sodium azide, butylated -anisole, superoxide dismutase and (II) suggest that the phototoxicity of TLM can be attributed essentially to singlet in the first step and to its photoproducts when they accumulate and compete with the starting drug in light absorption. |
6(0,0,1,1) | Details |
| 9681949 | Sziraki I, Mohanakumar KP, Rauhala P, Kim HG, Yeh KJ, Chiueh CC: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism. Neuroscience. 1998 Aug;85(4):1101-11. Without the contribution of manganese-superoxide dismutase was still effective in sodium azide and/or heat-pretreated brain homogenates. |
6(0,0,1,1) | Details |
| 19305903 | Okuda M, Tsuruta T, Katayama K: Lifetime and diffusion coefficient of active species generated in TiO2 sol solutions. Phys Chem Chem Phys. 2009 Apr 7;11(13):2287-92. Epub 2009 Feb 9. Transient responses were compared in the presence and absence of various kinds of scavengers such as sodium azide, and superoxide dismutase, and three components of the transient responses were assigned to peroxide, and radicals. |
6(0,0,1,1) | Details |
| 11030462 | Jancinova V, Drabikova K, Nosal R, Danihelova E: Platelet-dependent modulation of polymorphonuclear leukocyte chemiluminescence. Platelets. 2000 Aug;11(5):278-85. Superoxide dismutase with catalase and sodium azide were used, respectively, to differentiate the intracellular and the extracellular part of the chemiluminescence signal. |
6(0,0,1,1) | Details |
| 17512464 | Tintinger GR, Theron AJ, Potjo M, Anderson R: Reactive oxidants regulate membrane repolarization and store-operated uptake of by formyl peptide-activated human neutrophils. Free Radic Biol Med. 2007 Jun 15;42(12):1851-7. Epub 2007 Mar 24. In the current study, we have investigated the effects of superoxide dismutase (SOD), catalase, and the myeloperoxidase (MPO) inhibitors, sodium azide and 4-aminobenzoyl hydrazide (ABAH), as well as those of H (2) O (2) and HOCl (both at 100 microM) on the alterations in membrane potential which accompany activation of human neutrophils with the chemoattractant, FMLP (1 microM), and on store-operated uptake of Ca (2+). |
81(1,1,1,1) | Details |
| 11566276 | Gutierrez I, Criado S, Bertolotti S, Garcia NA: Dark and photoinduced interactions between Trolox, a polar-solvent-soluble model for and J Photochem Photobiol B. 2001 Sep 15;62(3):133-9. Complementary experiments performed in pure water employing superoxide dismutase and sodium azide inhibition of the uptake, in coincidence with flash photolysis data, indicate that and singlet molecular are generated, likely by the reaction of the anion radical from Rf with dissolved also yielding neutral, ground state Rf or by energy transfer from triplet Rf to ground-state respectively. |
31(0,1,1,1) | Details |
| 14644763 | Camara AK, Riess ML, Kevin LG, Novalija E, Stowe DF: Hypothermia augments reactive species detected in the guinea pig isolated perfused heart. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1289-99. Epub 2003 Nov 26. To validate our methods and to examine the source and identity of ROS during cold perfusion, we examined the effects of a superoxide dismutase mimetic Mn (III) tetrakis (4- (MnTBAP), the synthase inhibitor N (G)-nitro- methyl ester (l-NAME), and several agents that impair electron flux through the ETS: sodium azide (NaN (3)), and monoxime (BDM). |
31(0,1,1,1) | Details |
| 9404463 | Gourdon I, Guerin MC, Torreilles J: [Modulation of respiratory activity of renal macrophages in sea bass (Dicentrarchus labrax) by chronic exposure to sublethal concentration of C R Seances Soc Biol Fil. 1997;191(4):617-25. The stimulated-macrophage CL was partially inhibited by sodium azide, superoxide dismutase and a -synthesis inhibitor, the N5-(-1-iminoethyl)- monochloride, showing that peroxide, anions and were released by renal macrophages from sea bass during the respiratory burst. |
31(0,1,1,1) | Details |
| 8949646 | Millar AD, Rampton DS, Chander CL, Claxson AW, Blades S, Coumbe A, Panetta J, Morris CJ, Blake DR: Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Gut. 1996 Sep;39(3):407-15. RESULTS: The model was validated by demonstrating that the profile of effects on chemiluminescence of induced colitis biopsy specimens given by conventional antioxidants (sodium azide, catalase, -zinc superoxide dismutase, and and standard therapies (5-aminosalicylate and resembled that previously reported using biopsy specimens from ulcerative colitis. |
7(0,0,1,2) | Details |
| 12711275 | Vazzana M, Parrinello D, Cammarata M: Chemiluminescence response of beta-glucan stimulated leukocytes isolated from different tissues and peritoneal cavity of Dicentrarchus labrax. Fish Shellfish Immunol. 2003 May;14(5):423-34. Inhibition experiments by a myeloperoxidase inhibitor sodium azide, iodonium-diphenyl- which inhibits -oxidase, and exogenous superoxide dismutase, which catalyses O-2 dismutation to H (2) O (2), supported the correlation between CL and respiratory burst. |
81(1,1,1,1) | Details |
| 9021167 | Tsou TC, Yang JL: Formation of reactive species and DNA strand breakage during interaction of (III) and peroxide in vitro: evidence for a (III)-mediated Fenton-like reaction. Chem Biol Interact. 1996 Dec 20;102(3):133-53. Sodium azide, Tris-HCl, or catalase completely inhibited Cr (III)/H2O2-induced DNA breakage, but superoxide dismutase did not. |
81(1,1,1,1) | Details |
| 8951230 | Oakley GG, Devanaboyina U, Robertson LW, Gupta RC: Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer. Chem Res Toxicol. 1996 Dec;9(8):1285-92. The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl (2) (849 and 896 8-oxodG/10 (6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10 (6) nucleotides, respectively). |
81(1,1,1,1) | Details |
| 12573532 | Mondola P, Ruggiero G, Seru R, Damiano S, Grimaldi S, Garbi C, Monda M, Greco D, Santillo M: The Cu,Zn superoxide dismutase in neuroblastoma SK-N-BE cells is exported by a microvesicles dependent pathway. Brain Res Mol Brain Res. 2003 Jan 31;110(1):45-51. Immunofluorescence analysis shows that the enzyme is exported by microvesicular granules; moreover the treatment of cells with brefeldin A and with 2-deoxy- and sodium azide strongly decreases the amount of CuZn superoxide dismutase detected in the medium. |
34(0,1,1,4) | Details |
| 8397140 | Rathakrishnan C, Tiku ML: Lucigenin-dependent chemiluminescence in articular chondrocytes. . Free Radic Biol Med. 1993 Aug;15(2):143-9. Catalase and the metabolic inhibitor, sodium azide, which inhibits the enzyme myeloperoxidase, had no inhibitory effect on lucigenin-dependent chemiluminescence production. Only the antioxidant, superoxide dismutase, prevented lucigenin-dependent chemiluminescence, indicating that this assay measures the production of anions by chondrocytes. |
1(0,0,0,1) | Details |
| 11717389 | Helmerhorst EJ, Troxler RF, Oppenheim FG: The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42. Epub 2001 Nov 20. In contrast to histatin 5, the conventional inhibitors of the respiratory chain, or sodium azide, neither induced ROS nor killed yeast cells. In addition, the membrane-permeant superoxide dismutase mimetic 2,2,6,6-tetramethylpiperidine-N-oxyl, abolished histatin-induced ROS formation in isolated mitochondria. |
1(0,0,0,1) | Details |
| 8914358 | Ungpakorn R, Holdom MD, Hamilton AJ, Hay RJ: Purification and partial characterization of the Cu,Zn superoxide dismutase from the dermatophyte Trichophyton mentagrophytes var. interdigitale. Clin Exp Dermatol. 1996 May;21(3):190-6. The known Cu,Zn inhibitor caused some inhibition of the purified enzyme, whereas the inhibitors sodium azide, guanidinium hydrochloride, EDTA and chloroform/ had no discernible effect. |
2(0,0,0,2) | Details |
| 19390823 | Xu X, Zhou Y, Wei S, Ren D, Yang M, Bu H, Kang M, Wang J, Feng J: Molecular cloning and expression of a Cu/Zn-Containing superoxide dismutase from Thellungiella halophila. Mol Cells. 2009 Apr;27(4):423-8. Epub 2009 Apr 13. The SOD activity of ThCSD was inactivated by and peroxide but not by sodium azide, confirming that ThCSD is a Cu/Zn-SOD. |
2(0,0,0,2) | Details |
| 17880519 | Agrawal N, Ray RS, Farooq M, Pant AB, Hans RK: Photosensitizing potential of ciprofloxacin at ambient level of UV radiation. Photochem Photobiol. 2007 Sep-Oct;83(5):1226-36. Superoxide dismutase (SOD) inhibited 90-95% O2*- generation. Sodium azide (NaN3) and 1,4-diazabicyclo 2-2-2- (DABCO) inhibited the generation of 1O2. |
1(0,0,0,1) | Details |
| 15056492 | Razumovitch JA, Fuchs D, Semenkova GN, Cherenkevich SN: Influence of on generation of reactive species by myeloperoxidase in human neutrophils. Biochim Biophys Acta. 2004 Apr 7;1672(1):46-50. Comparing several scavengers, formation of reactive species was totally blocked by sodium azide (NaN (3)), both in the presence and in the absence of Superoxide dismutase (SOD) and insignificantly decreased chemiluminescence of this reaction, but diazabicyclo [2.2.2] (DABCO) strongly inhibited it. |
1(0,0,0,1) | Details |
| 8643080 | Li Y, Kuppusamy P, Zweir JL, Trush MA: Role of Cu/Zn-superoxide dismutase in xenobiotic activation. Mol Pharmacol. 1996 Mar;49(3):412-21. Similar to the HQ/Cu (II) and H202/Cu (II) systems, the DNA strand breaks mediated by HQ/Cu/Zn-SOD could not be effectively inhibited by the scavengers, including dimethylsulfoxide, and 5,5-dimethyl-1-pyrroline N-oxide, but could be protected by sodium azide. |
3(0,0,0,3) | Details |
| 11118588 | Gligic L, Radulovic Z, Zavisic G: Superoxide dismutase biosynthesis by two thermophilic bacteria. Enzyme Microb Technol. 2000 Dec;27(10):789-792. A slight decrease of SOD activity observed in the presence of 0.3 M and its complete insensitivity to peroxide (5 mM) and sodium azide (20 mM) action suggest that the enzyme occurring in the two thermophiles represents Mn SOD. |
2(0,0,0,2) | Details |
| 10694034 | Navari-Izzo F, Pinzino C, Quartacci MF, Sgherri CL: and generation, and superoxide dismutase in PSII membrane fragments from wheat. Free Radic Res. 1999 Dec;31 Suppl:S3-9. Photoreduction of nitroblue tetrazolium (NBT) by PSII membrane fragments was induced by the addition of sodium azide and peroxide. |
2(0,0,0,2) | Details |
| 8395887 | Leteurtre F, Fesen M, Kohlhagen G, Kohn KW, Pommier Y: Specific interaction of camptothecin, a topoisomerase I inhibitor, with residues of DNA detected by photoactivation at 365 nm. Biochemistry. 1993 Aug 31;32(34):8955-62. In aerobic conditions, the most effective scavengers were thiourea, sodium azide, and catalase. Protection by superoxide dismutase was weak, and was ineffective. |
1(0,0,0,1) | Details |
| 8628756 | Linetsky M, Ortwerth BJ: Quantitation of the reactive species generated by the UVA irradiation of -glycated lens proteins. Photochem Photobiol. 1996 May;63(5):649-55. High concentrations of sodium azide, a known singlet quencher, inhibited the photolytic destruction of both His and Trp. attained a level of 76 microM as determined by the superoxide dismutase (SOD)-dependent increase in peroxide formation and of 52 microM by the SOD-inhibitable reduction of cytochrome c. |
1(0,0,0,1) | Details |
| 9679665 | Kim RH, Lee SM, Park JW: Enhancement by zinc superoxide dismutase of DNA damage and mutagenicity with peroxide. Biochem Mol Biol Int. 1998 Jul;45(3):635-42. scavengers such as sodium azide, and 5,5-dimethyl-1-pyrroline N-oxide (DMPO), a metal chelator, diethylenetriamine-pentaacetic acid, and catalase decreased strand breaks and 8-OH-dG formation in DNA. |
2(0,0,0,2) | Details |
| 9125514 | Hunter T, Ikebukuro K, Bannister WH, Bannister JV, Hunter GJ: The conserved residue 34 is essential for maximal activity of iron-superoxide dismutase from Escherichia coli. Biochemistry. 1997 Apr 22;36(16):4925-33. SODY34F exhibited decreased thermal stability, reduced activity at high pH, and a pronounced increase in sensitivity to the inhibitor sodium azide compared with wild-type FeSOD. |
2(0,0,0,2) | Details |
| 15346198 | Wang BZ, Wei XB, Liu WY: Cleavage of supercoiled circular double-stranded DNA induced by a eukaryotic cambialistic superoxide dismutase from Cinnamomum camphora. Acta Biochim Biophys Sin. 2004 Sep;36(9):609-17. |
2(0,0,0,2) | Details |
| 15302891 | Regelsberger G, Laaha U, Dietmann D, Ruker F, Canini A, Grilli-Caiola M, Furtmuller PG, Jakopitsch C, Peschek GA, Obinger C: The iron superoxide dismutase from the filamentous cyanobacterium Nostoc PCC 7120. J Biol Chem. 2004 Oct 22;279(43):44384-93. Epub 2004 Aug 9. |
2(0,0,0,2) | Details |
| 10393342 | Yamano S, Sako Y, Nomura N, Maruyama T: A cambialistic SOD in a strictly aerobic hyperthermophilic archaeon, Aeropyrum pernix. J Biochem. 1999 Jul;126(1):218-25. Sodium azide, an inhibitor of SODs, did not inhibit the Mn-reconstituted SOD from A. pernix even at concentrations up to 400 mM. The superoxide dismutase (SOD) gene of Aeropyrum pernix, a strictly aerobic hyperthermophilic archaeon, was cloned and expressed in Escherichia coli, and its gene product was characterized. |
1(0,0,0,1) | Details |
| 7753758 | Takeyama Y, Ogino K, Segawa H, Kobayashi H, Uda T, Houbara T: Effects of zinc on production of active species by rat neutrophils. . Pharmacol Toxicol. 1995 Jan;76(1):50-5. at concentrations lower than 0.1 mM augmented the intensity of chemiluminescence and showed a bimodal pattern, the first peak of which was inhibited by superoxide dismutase and catalase, while the second peak disappeared in the presence of catalase, but was unaffected by superoxide dismutase. Homogenized neutrophils showed a bimodal pattern on induction by zinc, the second peak of which was inhibited slightly by catalase and completely by sodium azide, but was not inhibited by superoxide dismutase. |
1(0,0,0,1) | Details |
| 18164679 | Jeanjean R, Latifi A, Matthijs HC, Havaux M: The PsaE subunit of photosystem I prevents light-induced formation of reduced species in the cyanobacterium Synechocystis sp. Biochim Biophys Acta. 2008 Mar;1777(3):308-16. Epub 2007 Dec 5. The expression of the genes encoding catalase (katG) and iron superoxide dismutase (sodB) was upregulated in the DeltapsaE mutant, and the increase in katG expression was correlated with an increase in catalase activity of the cells. When catalases were inhibited by sodium azide, the production of reactive species was enhanced in DeltapsaE relative to WT. |
1(0,0,0,1) | Details |
| 12590362 | Ho KJ, Liu TK, Huang TS, Lu FJ: Humic acid mediates iron release from ferritin and promotes lipid peroxidation in vitro: a possible mechanism for humic acid-induced cytotoxicity. Arch Toxicol. 2003 Feb;77(2):100-9. Epub 2002 Dec 17. In addition, the increase in HA-induced lipid peroxidation is partially inhibited by sodium azide (a singlet scavenger) or disodium 4,5-dihydroxy-1,3--disulfonic acid (a scavenger), reflecting the involvement of singlet and in the process of lipid peroxidation. The addition of HA into a reaction system has been shown to generate in a dose-dependent manner by the superoxide dismutase-inhibitable cytochrome c reduction assay. |
1(0,0,0,1) | Details |
| 12392545 | Hunter T, Bannister JV, Hunter GJ: Thermostability of - and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a residue. Eur J Biochem. 2002 Nov;269(21):5137-48. |
2(0,0,0,2) | Details |
| 14979716 | Gogliettino MA, Tanfani F, Scire A, Ursby T, Adinolfi BS, Cacciamani T, De Vendittis E: The role of Tyr41 and His155 in the functional properties of superoxide dismutase from the archaeon Sulfolobus solfataricus. Biochemistry. 2004 Mar 2;43(8):2199-208. After H155Q and even more after the Y41F substitution, the archaeal enzyme acquires a moderate sensitivity to sodium azide inhibition. |
2(0,0,0,2) | Details |
| 16417455 | Klebanov GI, Poltanov EA, Chichuk TV, Osipov AN, Vladimirov YA: Changes in superoxide dismutase activity and content in rat peritoneal macrophages exposed to He-Ne laser radiation. Biochemistry. 2005 Dec;70(12):1335-40. |
2(0,0,0,2) | Details |
| 15562629 | Steverding D, Scory S: Trypanosoma brucei: unexpected azide sensitivity of bloodstream forms. J Parasitol. 2004 Oct;90(5):1188-90. So far, the only enzyme known in bloodstream forms of T. brucei to be sensitive to azide is the iron-containing superoxide dismutase. |
1(0,0,0,1) | Details |
| 8260663 | Deshpande RG, Khan MB, Savariar LS, Windham YZ, Navalkar RG: Superoxide dismutase activity of Mycobacterium avium complex (MAC) strains isolated from AIDS patients. Tuber Lung Dis. 1993 Oct;74(5):305-9. |
1(0,0,0,1) | Details |
| 8819196 | Benbarek H, Deby-Dupont G, Deby C, Caudron I, Mathy-Hartert M, Lamy M, Serteyn D: Experimental model for the study by chemiluminescence of the activation of isolated equine leucocytes. Res Vet Sci. 1996 Jul;61(1):59-64. Superoxide dismutase (100 IU) totally inhibited the chemiluminescence response. |
1(0,0,0,1) | Details |
| 8161207 | Partridge RS, Monroe SM, Parks JK, Johnson K, Parker WD Jr, Eaton GR, Eaton SS: Spin trapping of azidyl and in azide-inhibited rat brain submitochondrial particles. Arch Biochem Biophys. 1994 Apr;310(1):210-7. It is proposed that azide inhibition of cytochrome c oxidase results in increased production of which is efficiently converted to peroxide by membrane-bound superoxide dismutase. |
1(0,0,0,1) | Details |
| 9603282 | Grossman N, Schneid N, Reuveni H, Halevy S, Lubart R: 780 nm low power diode laser irradiation stimulates proliferation of keratinocyte cultures: involvement of reactive species. Lasers Surg Med. 1998;22(4):212-8. Added enzymatic antioxidants, superoxide dismutase or catalase, scavenging anions and H2O2, suppressed this enhanced proliferation. Added scavengers scavenging lipid peroxidation, or sodium azide, scavenging singlet anions, and respectively), or N-acetyl the thiol-reducing agent, suppressed the response, but to different extents. |
1(0,0,0,1) | Details |
| 15720116 | Cherng SH, Xia Q, Blankenship LR, Freeman JP, Wamer WG, Howard PC, Fu PP: Photodecomposition of in by UVA light-formation of photodecomposition products, reactive species, and lipid peroxides. Chem Res Toxicol. 2005 Feb;18(2):129-38. The lipid peroxide formation was inhibited by (DTT) (free radical scavenger), NaN3 (singlet and free radical scavenger), and superoxide dismutase (SOD) scavenger) but was enhanced by the presence of deuterium oxide (D2O) (enhancement of singlet lifetime). Formation of these photodecomposition products was inhibited in the presence of sodium azide (NaN3), a free radical inhibitor. |
1(0,0,0,1) | Details |
| 9880816 | Yamano S, Maruyama T: An azide-insensitive superoxide dismutase from a hyperthermophilic archaeon, Sulfolobus solfataricus. J Biochem. 1999 Jan;125(1):186-93. |
2(0,0,0,2) | Details |
| 19060940 | Kosenko EA, Solomadin IN, Marov NV, Venediktova NI, Pogosian AS, Kaminskii IuG: [Role of glycolysis and antioxidant enzymes in the toxicity of amyloid beta peptide Abeta25-35 to erythrocytes]. Bioorg Khim. 2008 Sep-Oct;34(5):654-60. a Cu,Zn-superoxide dismutase inhibitor, abolishes the toxic effect of Abeta (25-35) to erythrocytes, whereas mercaptosuccinate, a peroxidase inhibitor, and ouabain, a Na+,K+-ATPase inhibitor, promote it. Sodium azide, a catalase inhibitor, did not affect the cell lysis under the action of Abeta (25-35) . |
2(0,0,0,2) | Details |
| 16210058 | Bacsi A, Dharajiya N, Choudhury BK, Sur S, Boldogh I: Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol. 2005 Oct;116(4):836-43. Epub 2005 Aug 19. RESULTS: Ragweed pollen grains contain NAD (P) H oxidase activity, which is diphenyleneiodonium-sensitive and quinacrine-sensitive and sodium azide-resistant. These NAD (P) H oxidases generate a that can be converted to H2O2 by pollen grain-associated superoxide dismutase. |
1(0,0,0,1) | Details |
| 11166292 | Nelli S, McIntosh L, Martin W: Role of ions and cytochrome P450 in the vasodilator actions of the anion generator, Angeli's salt, on rat aorta. Eur J Pharmacol. 2001 Feb 2;412(3):281-9. sulphate enhanced relaxation to Angeli's salt and SNAP but this resulted from reduced destruction of by rather than from enhanced generation of since it was mimicked by superoxide dismutase and by the superoxide dismutase mimetic, MnCl2. |
1(0,0,0,1) | Details |
| 15659779 | Chun YS, Yeo EJ, Suh HJ, Park JW: Spontaneous generation of reactive species in the mixture of and Ann N Y Acad Sci. 2004 Dec;1030:43-51. However, and sodium azide in combination do not produce such artifacts and thus may be used as an alternative. In assaying prooxidant or antioxidant activities, has been commonly used as an inhibitor of mitochondrial oxidases, peroxidases, or Cu,Zn-superoxide dismutase, which have an influence on intracellular levels of reactive species. |
1(0,0,0,1) | Details |
| 17900002 | Okai Y, Sato EF, Higashi-Okai K, Inoue M: Potentiating effect of an endocrine disruptor, paranonylphenol, on the generation of reactive species (ROS) in human venous blood -- association with the activation of signal transduction pathway. J UOEH. 2007 Sep 1;29(3):221-33. ROS-scavenging enzymes such as catalase and superoxide dismutase, and the lipophilic antioxidative agents, and showed preventive effects on NP-induced ROS generation. An -dependent oxidase inhibitor, diphenyl iodonium (DPI), and a myeloperoxidase inhibitor, sodium azide (NaN3), showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, (KCN), did not exhibit a significant effect. |
1(0,0,0,1) | Details |
| 10579466 | Orie NN, Zidek W, Tepel M: and /calmodulin kinases are common signaling components in the generation of reactive species in human lymphocytes. Life Sci. 1999;65(20):2135-42. These increases were significantly inhibited by catalase, sodium azide, and dimethylsulfoxide but not by superoxide dismutase, suggesting that the ROS apparently included peroxide, singlet and but not |
0(0,0,0,0) | Details |
| 8001838 | Dubinina EE, Shugaley IV, Melenevsky AT, Tselinskii IV: Characteristics of low molecular weight substances regulating plasma superoxide dismutase activity. Free Radic Biol Med. 1994 Oct;17(4):351-3. |
2(0,0,0,2) | Details |
| 10858207 | Kim TS, Jung Y, Na BK, Kim KS, Chung PR: Molecular cloning and expression of Cu/Zn-containing superoxide dismutase from Fasciola hepatica. Infect Immun. 2000 Jul;68(7):3941-8. Staining of native polyacrylamide gel for SOD activity of the expressed protein revealed SOD activity that was inactivated by and peroxide but not by sodium azide. |
2(0,0,0,2) | Details |
| 11536143 | Bai Z, Harvey LM, McNeil B: Use of the chemiluminescent probe lucigenin to monitor the production of the radical in a recombinant Aspergillus niger (B1-D). Biotechnol Bioeng. 2001 Oct 20;75(2):204-11. In the presence of exogenous superoxide dismutase (SOD), the LDCL of a disrupted cell solution was inhibited. In contrast, with addition of diethyldithiocarbamate and sodium azide, respectively, the inhibitors of Cu, Zn-SOD and Mn-SOD, an increased LDCL was observed. |
1(0,0,0,1) | Details |
| 8613689 | Yumita N, Umemura S, Magario N, Umemura K, Nishigaki R: Membrane lipid peroxidation as a mechanism of sonodynamically induced erythrocyte lysis. Int J Radiat Biol. 1996 Mar;69(3):397-404. The sonodynamically induced lipid peroxidation with Hp was doubled by deuterium oxide substitution for suspension medium and was significantly reduced by by sodium azide, and also by substitution for saturation gas, whereas superoxide dismutase and showed no significant inhibitory effect. |
0(0,0,0,0) | Details |
| 15165050 | Cho MH, Na BK, Song KJ, Cho JH, Kang SW, Lee KH, Song CY, Kim TS: Cloning, expression, and characterization of iron-containing superoxide dismutase from Neospora caninum. J Parasitol. 2004 Apr;90(2):278-85. Enzyme activity of the expressed protein was inhibited by peroxide but not by sodium azide and and the enzyme showed similar biochemical properties with typical Fe-SODs of other parasitic protozoans. |
2(0,0,0,2) | Details |
| 9521765 | Leone M, Cupane A, Militello V, Stroppolo ME, Desideri A: Fourier transform infrared analysis of the interaction of azide with the active site of oxidized and reduced bovine Cu,Zn superoxide dismutase. Biochemistry. 1998 Mar 31;37(13):4459-64. |
2(0,0,0,2) | Details |
| 15856906 | Lee WG, Hwang JH, Na BK, Cho JH, Lee HW, Cho SH, Kong Y, Song CY, Kim TS: Functional expression of a recombinant /zinc superoxide dismutase of filarial nematode, Brugia malayi. J Parasitol. 2005 Feb;91(1):205-8. Enzyme activity of the recombinant protein was inhibited by and peroxide but not by sodium azide. |
2(0,0,0,2) | Details |
| 11305606 | Hirayama J, Wagner SJ, Abe H, Ikebuchi K, Ikeda H: Involvement of reactive species in hemoglobin oxidation and virus inactivation by 1,9-dimethylmethylene blue phototreatment. Biol Pharm Bull. 2001 Apr;24(4):418-21. Virus (R17 bacteriophage) photoinactivation by either activated monomer or dimer DMMB was suppressed by sodium azide (singlet quencher) and promoted by the substitution of for deuterium oxide (D2O), which is known to prolong the lifespan of singlet |
0(0,0,0,0) | Details |
| 9254898 | Maramag C, Menon M, Balaji KC, Reddy PG, Laxmanan S: Effect of on prostate cancer cells in vitro: effect on cell number, viability, and DNA synthesis. Prostate. 1997 Aug 1;32(3):188-95. However, that singlet scavengers such as sodium azide and and scavengers such as and did not counteract the effects of on incorporation suggests that -induced changes do not occur through the generation of these ROS. |
0(0,0,0,0) | Details |
| 8757871 | Holdom MD, Hay RJ, Hamilton AJ: The Cu,Zn superoxide dismutases of Aspergillus flavus, Aspergillus niger, Aspergillus nidulans, and Aspergillus terreus: purification and biochemical comparison with the Aspergillus fumigatus Cu,Zn superoxide dismutase. Infect Immun. 1996 Aug;64(8):3326-32. Sodium azide and o-phenanthroline demonstrated inhibition at concentrations from 5 to 30 mM, and EDTA also exhibited a varying degree of inhibition of SOD activity. |
2(0,0,0,2) | Details |
| 16615865 | Brioukhanov AL, Nesatyy VJ, Netrusov AI: Purification and characterization of Fe-containing superoxide dismutase from Methanobrevibacter arboriphilus strain AZ. Biochemistry. 2006 Apr;71(4):441-7. Sodium azide (13.5 mM), unlike KCN, inhibits the activity of the SOD. |
2(0,0,0,2) | Details |
| 8526746 | Lee TC, Ho IC: Modulation of cellular antioxidant defense activities by arsenite in human fibroblasts. Arch Toxicol. 1995;69(7):498-504. arsenite-enhanced heme oxygenase synthesis was inhibited by co-treatment of cells with the antioxidants sodium azide and |
0(0,0,0,0) | Details |
| 8031139 | Park JW, Floyd RA: Generation of strand breaks and formation of in DNA by a Thiol/Fe3+/O2-catalyzed oxidation system. Arch Biochem Biophys. 1994 Jul;312(1):285-91. Sodium azide and as well as a metal chelator, diethylenetriaminepentaactic acid, decreased strand breaks and 8-OH-dG formation in DNA. |
0(0,0,0,0) | Details |
| 8179634 | Park JW, Kim HK: Strand scission in DNA induced by S-nitrosothiol with peroxide. Biochem Biophys Res Commun. 1994 Apr 29;200(2):966-72. Sodium azide and inhibited S-nitrosothiol/H2O2-induced strand breaks in DNA. |
0(0,0,0,0) | Details |
| 10564779 | Choi SY, Kwon HY, Kwon OB, Kang JH: peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by and Biochim Biophys Acta. 1999 Nov 16;1472(3):651-7. scavengers such as sodium azide, and protected the fragmentation of Cu,Zn-SOD. |
2(0,0,0,2) | Details |
| 15020251 | Bhattacharya J, GhoshDastidar K, Chatterjee A, Majee M, Majumder AL: Synechocystis Fe superoxide dismutase gene confers oxidative stress tolerance to Escherichia coli. Biochem Biophys Res Commun. 2004 Apr 2;316(2):540-4. The SOD activity of the recombinant protein was sensitive to peroxide and sodium azide, confirming it to be FeSOD. |
2(0,0,0,2) | Details |
| 7673115 | Gergel D, Misik V, Ondrias K, Cederbaum AI: Increased cytotoxicity of 3-morpholinosydnonimine to HepG2 cells in the presence of superoxide dismutase. J Biol Chem. 1995 Sep 8;270(36):20922-9. Catalase abolished, while sodium azide potentiated, this toxicity, suggesting a key role for H2O2 in the overall mechanism. |
2(0,0,0,2) | Details |
| 9665739 | Liu Z, Lu Y, Rosenstein B, Lebwohl M, Wei H: Benzo [a] pyrene enhances the formation of by ultraviolet A radiation in calf thymus DNA and human epidermoid carcinoma cells. Biochemistry. 1998 Jul 14;37(28):10307-12. The results showed that only superoxide dismutase and significantly quenched BaP plus UVA-induced whereas catalase, sodium azide, and exhibited no effect. |
0(0,0,0,0) | Details |
| 8598491 | Hansson M, Asea A, Ersson U, Hermodsson S, Hellstrand K: Induction of apoptosis in NK cells by monocyte-derived reactive metabolites. J Immunol. 1996 Jan 1;156(1):42-7. Sodium azide, a myeloperoxidase inhibitor, substantially reduced the monocyte-induced apoptosis in NK cells. |
0(0,0,0,0) | Details |
| 9009302 | Hamilton AJ, Holdom MD: Biochemical comparison of the Cu,Zn superoxide dismutases of Cryptococcus neoformans var. neoformans and Cryptococcus neoformans var. gattii. Infect Immun. 1997 Feb;65(2):488-94. The activities of the enzymes from both varieties were inhibited by KCN; however, the chelator diethyldithiocarbamate was inhibitory only against the C. neoformans var. gattii enzyme, as was sodium azide. |
2(0,0,0,2) | Details |
| 8595063 | Vargas F, Matskevitch V, Sarabia Z: Photodegradation and in vitro phototoxicity of the antidiabetic drug chlorpropamide. Arzneimittelforschung. 1995 Oct;45(10):1079-81. Inhibition of this process on addition of (GSH), superoxide dismutase (SOD) or suggests the involvement of radicals and ion in the photohemolysis process. The absence of inhibition with 1,4-diazabicyclo [2.2.2] (DABCO) and sodium azide (NaN3), and the lack of formation of singlet during the photolysis (confirmed with 2,5-dimethylfuran) rule out the possibility of participation of 1O2 in this process. |
1(0,0,0,1) | Details |
| 10193578 | Gutierrez-Correa J, Stoppani AO: Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, and thiol compounds. Free Radic Res. 1999 Feb;30(2):105-17. The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by and LADH inactivation by the MPO//halide systems was prevented by catalase and enhanced by superoxide dismutase, in close agreement with H2O2 production by the LADH/ system. |
1(0,0,0,1) | Details |
| 9026352 | Afonso SG, Polo CF, Enriquez de Salamanca R, Batlle A: Mechanistic studies on -induced photoinactivation of some heme-enzymes. Int J Biochem Cell Biol. 1996 Apr;28(4):415-20. The presence of sodium azide, or superoxide dismutase did not protect the enzymes against the effects of |
0(0,0,0,0) | Details |
| 10443929 | Liu Z, Lu Y, Lebwohl M, Wei H: PUVA (8-methoxy-psoralen plus ultraviolet A) induces the formation of and DNA fragmentation in calf thymus DNA and human epidermoid carcinoma cells. Free Radic Biol Med. 1999 Jul;27(1-2):127-33. The results showed that only sodium azide and significantly quenched PUVA-induced whereas catalase, superoxide dismutase, and exhibited no effect. |
0(0,0,0,0) | Details |
| 8699394 | Yamada K, Ono T, Nishioka H: Effect of NaN3 on -dependent lethality of UV-A in Escherichia coli mutants lacking active -defence and DNA-repair systems. J Radiat Res. 1996 Mar;37(1):29-37. Escherichia coli mutants which lack defence systems against such active forms as OxyR (delta oxyR), superoxide dismutase (SOD) (sodA and sodB) and catalase (katE and katG) are sensitive to UV-A lethality under aerobic conditions, whereas OxyR- and SOD-mutants have resistance under anaerobic conditions and in the presence of sodium azide (NaN3) during irradiation. |
6(0,0,1,1) | Details |
| 16124792 | Wilson B, Gude L, Fernandez MJ, Lorente A, Grant KB: Tunable DNA photocleavage by an acridine- conjugate. . Inorg Chem. 2005 Sep 5;44(18):6159-73. Sodium azide, superoxide dismutase, and catalase indicate the involvement of type I and II photochemical processes in the metal-assisted DNA photocleavage reactions. |
6(0,0,1,1) | Details |
| 10781728 | Chen JR, Weng CN, Ho TY, Cheng IC, Lai SS: Identification of the -zinc superoxide dismutase activity in Mycoplasma hyopneumoniae. Vet Microbiol. 2000 May 11;73(4):301-10. |
1(0,0,0,1) | Details |
| 17964427 | Kell A, Ventura N, Kahn N, Johnson TE: Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec 1;43(11):1560-6. Epub 2007 Sep 7. The SKN-1 transcription factor specifies cell fate of the EMS blastomere at the four-cell stage in the nematode Caenorhabditis elegans and also directs transcription of many genes responding to oxidative stress, including glutathione S-transferase, NAD (P) H:quinone oxidoreductase, and superoxide dismutase. SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric and sodium azide. |
1(0,0,0,1) | Details |
| 17056004 | Mubarakshina M, Khorobrykh S, Ivanov B: reduction in chloroplast thylakoids results in production of peroxide inside the membrane. Biochim Biophys Acta. 2006 Nov;1757(11):1496-503. Epub 2006 Sep 20. Neither the presence of a superoxide dismutase inhibitor, or sodium azide, in the thylakoid suspension, nor unstacking of the thylakoids appreciably affected the partitioning of electrons to peroxide production. |
0(0,0,0,0) | Details |
| 7750790 | Rohn TT, Hinds TR, Vincenzi FF: Inhibition by activated neutrophils of the Ca2+ pump ATPase of intact red blood cells. Free Radic Biol Med. 1995 Apr;18(4):655-67. The addition of sodium azide, a potent inhibitor of endogenous RBC catalase, enhanced inhibition of the Ca2+ pump ATPase of intact RBCs. |
0(0,0,0,0) | Details |
| 9923964 | Menon M, Maramag C, Malhotra RK, Seethalakshmi L: Effect of on androgen independent prostate cancer cells (PC3 and Mat-Ly-Lu) in vitro: involvement of reactive species-effect on cell number, viability and DNA synthesis. Cancer Biochem Biophys. 1998 Jun;16(1-2):17-30. That singlet scavengers such as sodium azide and scavengers such as and did not counteract the effects of on incorporation suggests that these free radicals are not involved in cellular damage. |
0(0,0,0,0) | Details |
| 19199143 | Szeto YT, Sok Wa Leong K, Keong Lam K, Min Min Hong C, Kai Mui Lee D, Teng Fun Chan Y, Benzie IF: Effects of incense smoke on human lymphocyte DNA. J Toxicol Environ Health A. 2009;72(6):369-73. Catalase (CAT), sodium azide, and superoxide dismutase (SOD) were co-incubated with extract, which exerted significant DNA damaging effects. |
6(0,0,1,1) | Details |
| 15386798 | Zhu D, Xing D, Wei Y, Li X, Gao B: Evaluation of the degree of medical radiation damage with a highly sensitive chemiluminescence method. Luminescence. 2004 Sep-Oct;19(5):278-82. In addition, the effects of catalase, Cu-Zn superoxide dismutase (SOD), sodium azide (NaN (3)), and D (2) O on MCLA-dependent CL of lymphocytes are discussed. |
6(0,0,1,1) | Details |
| 8055842 | Ishizaki T, Yano E, Urano N, Evans PH: Crocidolite-induced reactive metabolites generation from human polymorphonuclear leukocytes. Environ Res. 1994 Aug;66(2):208-16. Superoxide dismutase, catalase, and which are scavengers of O2-, H2O2, and OH., respectively, inhibited the production of crocidolite-stimulated CL from PMN, also in a dose-dependent manner. Sodium azide, an inhibitor of myeloperoxidase (MPO) to produce OCl-, also inhibited CL production. |
1(0,0,0,1) | Details |
| 8747893 | Salman-Tabcheh S, Guerin MC, Torreilles J: Potential role of the peroxidase-dependent metabolism of in lowering the polymorphonuclear leukocyte bactericidal function. Free Radic Res. 1996 Jan;24(1):61-8. The addition of catalase or sodium azide substantially reduced this binding. |
0(0,0,0,0) | Details |
| 7954331 | Sahu SC, Gray GC: -induced nuclear DNA damage and lipid peroxidation. Cancer Lett. 1994 Oct 14;85(2):159-64. Catalase, superoxide dismutase (SOD), and sodium azide did not show any inhibitory effect on the -induced nuclear DNA damage in the presence of iron (III) or (II). |
0(0,0,0,0) | Details |
| 9383993 | Hirayama J, Ikebuchi K, Abe H, Kwon KW, Ohnishi Y, Horiuchi M, Shinagawa M, Ikuta K, Kamo N, Sekiguchi S: Photoinactivation of virus infectivity by hypocrellin A. Photochem Photobiol. 1997 Nov;66(5):697-700. The removal of or addition of sodium azide or both inhibited VSV inactivation. |
0(0,0,0,0) | Details |
| 8531024 | Tesfa-Selase F, Hay RJ: Superoxide dismutase of Cryptococcus neoformans: purification and characterization. J Med Vet Mycol. 1995 Jul-Aug;33(4):253-9. The enzyme was inhibited by sodium azide, o-phenanthroline, and EDTA, in descending order. |
5(0,0,0,5) | Details |
| 8918957 | Roberts B, Hirst R: Identification and characterisation of a superoxide dismutase and catalase from Mycobacterium ulcerans. J Med Microbiol. 1996 Nov;45(5):383-7. |
5(0,0,0,5) | Details |
| 16713057 | Castellano I, Di Maro A, Ruocco MR, Chambery A, Parente A, Di Martino MT, Parlato G, Masullo M, De Vendittis E: Psychrophilic superoxide dismutase from Pseudoalteromonas haloplanktis: biochemical characterization and identification of a highly reactive residue. Biochimie. 2006 Oct;88(10):1377-89. Epub 2006 Apr 27. The enzyme is inhibited by sodium azide and inactivated by peroxide; it is also very sensitive to peroxynitrite, a physiological inactivator of the human mitochondrial Mn-SOD. |
4(0,0,0,4) | Details |
| 8016214 | Kato Y, Uchida K, Kawakishi S: Aggregation of collagen exposed to UVA in the presence of a plausible role of modification. Photochem Photobiol. 1994 Mar;59(3):343-9. Sodium azide or 1,4-diazabicyclo (2,2,2) which are known to be singlet quenchers, and catalase could not inhibit the modification. Surprisingly, the collagen modification was accelerated in the presence of superoxide dismutase. |
1(0,0,0,1) | Details |
| 15064160 | Okai Y, Sato EF, Higashi-Okai K, Inoue M: Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive species in human blood neutrophils. Environ Health Perspect. 2004 Apr;112(5):553-6. Furthermore, ROS-scavenging enzymes such as catalase and superoxide dismutase and antioxidative agents and showed strong preventive effects on NP-induced ROS generation. -dependent oxidase inhibitor, diphenyl iodonium and the myeloperoxidase inhibitor sodium azide (NaN3) showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, (KCN), did not exhibit significant effect. |
1(0,0,0,1) | Details |
| 11332879 | Petersen AB, Gniadecki R, Vicanova J, Thorn T, Wulf HC: peroxide is responsible for UVA-induced DNA damage measured by alkaline comet assay in HaCaT keratinocytes. J Photochem Photobiol B. 2000 Dec;59(1-3):123-31. Singlet (1O2) did not seem to play an important role in the UVA-induced DNA-damage since the specific 1O2 scavenger sodium azide (NaN3) and the less specific 1O2 scavenger did not markedly prevent either DNA-damage or H2O2 production. (O2*-) was a likely substrate for H2O2 production since diethyldithiocarbamate (DDC), a superoxide dismutase blocker, decreased the level of intracellular H2O2. |
1(0,0,0,1) | Details |
| 9566705 | Sahu SC, Eppley RM, Page SW, Gray GC, Barton CN, O'Donnell MW: Peroxidation of membrane lipids and oxidative DNA damage by fumonisin B1 in isolated rat liver nuclei. Cancer Lett. 1998 Mar 13;125(1-2):117-21. In addition, the active scavengers catalase, superoxide dismutase (SOD), and sodium azide had no significant inhibitory effects on the FB1-induced DNA strand breaks. |
0(0,0,0,0) | Details |
| 12727198 | Afzal M, Matsugo S, Sasai M, Xu B, Aoyama K, Takeuchi T: Method to overcome photoreaction, a serious drawback to the use of dichlorofluorescin in evaluation of reactive species. Biochem Biophys Res Commun. 2003 May 16;304(4):619-24. Although reactive species scavengers, such as catalase, superoxide dismutase, and sodium azide, did not suppress the increase in non-specified fluorescence, reagents such as mercaptopropionyl and methoxycinnamic acid, in a cell-free system, almost completely suppressed it with little effect on the fluorescence of DCF. |
0(0,0,0,0) | Details |
| 9300140 | Sarkar B, Das U, Bhattacharyya S, Bose SK: Studies on the aerobic photooxidation of using as a sensitizer: evidence for the photogeneration of a and peroxide. Biol Pharm Bull. 1997 Aug;20(8):910-2. The effects of various scavengers, such as superoxide dismutase, catalase, sodium azide and ferrocyanide (an electron donor), on the photooxidation were determined. |
6(0,0,1,1) | Details |
| 9390169 | Reinke LA, Moore DR, McCay PB: Mechanisms for metabolism of to 1-hydroxyethyl radicals in rat liver microsomes. Arch Biochem Biophys. 1997 Dec 1;348(1):9-14. The variables tested include addition of azide, catalase, superoxide dismutase, and deferoxamine, or use of or Tris buffers. |
3(0,0,0,3) | Details |
| 18717521 | Yin JJ, Xia Q, Fu PP: UVA photoirradiation of anhydroretinol--formation of singlet and Toxicol Ind Health. 2007 Nov;23(10):625-31. During photoirradiation in the presence of 5,5-dimethyl N-oxide pyrroline (DMPO), a specific probe for ESR signals for DMPO-OOH were formed, and these signals were quenched by superoxide dismutase. The involvement of singlet on the induction of lipid peroxidation was also evidenced by the observation that lipid peroxidation was inhibited by sodium azide and enhanced by deuterium oxide. |
1(0,0,0,1) | Details |
| 15620721 | Lapenna D, Ciofani G, Pierdomenico SD, Giamberardino MA, Cuccurullo F: zinc superoxide dismutase plus peroxide: a catalytic system for human lipoprotein oxidation. FEBS Lett. 2005 Jan 3;579(1):245-50. |
1(0,0,0,1) | Details |
| 10716039 | Jordan CG, Brown K, Beedham C, Brown JE: Effect of inhibitors on the biotransformation of tamoxifen by female rat and mouse liver slices and homogenates. Drug Metabol Drug Interact. 1999;15(4):239-58. When rat liver homogenates was incubated with superoxide dismutase (SOD) and catalase, it was observed that the N-desmethyl metabolite disappeared completely at 60 min and the N-oxide and 4- metabolites were completely inhibited. Female rat liver slices and homogenates were incubated with the following inhibitors (1 mM): cimetidine, sodium azide and |
1(0,0,0,1) | Details |
| 9358240 | Zhang X, Rosenstein BS, Wang Y, Lebwohl M, Wei H: Identification of possible reactive species involved in ultraviolet radiation-induced oxidative DNA damage. Free Radic Biol Med. 1997;23(7):980-5. Sodium azide, a singlet (1O2) scavenger though its quenching effect on HO. was also reported, inhibited 8-oxodGuo production in calf thymus DNA exposed to UVA, UVB, or UVC in a concentration-dependent fashion with maximal quenching effect of over 90% at a concentration of 10 mM. |
0(0,0,0,0) | Details |
| 8929553 | Bednar MM, Balazy M, Murphy M, Booth C, Fuller SP, Barton A, Bingham J, Golding L, Gross CE: augments fMLP-stimulated chemiluminescence by neutrophils in human whole blood. J Leukoc Biol. 1996 Nov;60(5):619-24. Both sodium azide and significantly inhibited LDCL (93% inhibition with 100 microM azide, 52% inhibition with 10 mM |
0(0,0,0,0) | Details |
| 17646712 | Seo SN, Lee JH, Kim YM: Characterization of an iron- and manganese-containing superoxide dismutase from Methylobacillus sp. strain SK1 DSM 8269. Mol Cells. 2007 Jun 30;23(3):370-8. peroxide and sodium azide, but not was found to inhibit the purified enzyme. |
3(0,0,0,3) | Details |
| 18751544 | Guo FX, Shi-Jin E, Liu SA, Chen J, Li DC: Purification and characterization of a thermostable MnSOD from the thermophilic fungus Chaetomium thermophilum. Mycologia. 2008 May-Jun;100(3):375-80. A thermostable superoxide dismutase (SOD) from the culture supernatant of a thermophilic fungus Chaetomium thermophilum strain CT2 was purified to homogeneity by fractional ammonium precipitation, ion-exchange chromatography on DEAE-sepharose, phenyl-sepharose hydrophobic interaction chromatography. |
3(0,0,0,3) | Details |
| 7833505 | Demiryurek AT, Wainwright CL, Wadsworth RM, Kane KA: Characterization of a method for the detection of drugs with free radical scavenging activity using porcine leukocytes. J Pharmacol Toxicol Methods. 1994 Sep;32(1):35-40. Superoxide dismutase (0.1 units/mL) and catalase (50 units/mL) inhibited X-XO, but they were ineffective in leukocyte suspensions except at concentrations 500 times and 20 times higher. Sodium azide (10 (-5) to 10 (-3) M) caused a marked inhibition in CL production in activated leukocytes, but not of X-XO CL. |
1(0,0,0,1) | Details |
| 14998234 | Gopalakrishnan A, Ji LL, Cirelli C: Sleep deprivation and cellular responses to oxidative stress. Sleep. 2004 Feb 1;27(1):27-35. MEASUREMENTS AND RESULTS: Aliquots of brain, liver, or skeletal muscle homogenate were used to assess oxidant production, superoxide dismutase activity, lipid peroxidation, and protein oxidation. |
1(0,0,0,1) | Details |
| 8033320 | Li Y, Trush MA, Yager JD: DNA damage caused by reactive species originating from a -dependent oxidation of the 2- of Carcinogenesis. 1994 Jul;15(7):1421-7. The appearance of strand breaks was also blocked by catalase and inhibited by the singlet scavengers sodium azide and 2,2,6,6-tetramethyl-4-piperidone. |
0(0,0,0,0) | Details |
| 10491304 | Osada M, Ogura Y, Yasui H, Sakurai H: Involvement of singlet in cytochrome P450-dependent substrate oxidations. Biochem Biophys Res Commun. 1999 Sep 24;263(2):392-7. The addition of a quencher of singlet species ((1) O (2)), suppressed the hydroxylation, while the addition of sodium azide (NaN (3)) ((1) O (2) quencher) enhanced the reaction. |
0(0,0,0,0) | Details |
| 7633574 | Holdom MD, Hay RJ, Hamilton AJ: Purification, N-terminal amino acid sequence and partial characterization of a Cu,Zn superoxide dismutase from the pathogenic fungus Aspergillus fumigatus. Free Radic Res. 1995 Jun;22(6):519-31. and diethyldithiocarbamate, known Cu,Zn SOD inhibitors, caused inhibition of the purified enzyme at working concentrations of 0.25 mM, whilst sodium azide and o-phenanthroline demonstrated inhibition at higher concentrations (10-30 mM). |
3(0,0,0,3) | Details |
| 9509413 | An SS, Kim YM: Purification and characterization of a manganese-containing superoxide dismutase from a carboxydobacterium, Pseudomonas carboxydohydrogena. Mol Cells. 1997 Dec 31;7(6):730-7. Sodium azide, but not and peroxide, was found to inhibit the enzyme activity. |
3(0,0,0,3) | Details |
| 19229500 | Song NN, Zheng Y, E SJ, Li DC: Cloning, expression, and characterization of thermostable manganese superoxide dismutase from Thermoascus aurantiacus var. levisporus. J Microbiol. 2009 Feb;47(1):123-30. Epub 2009 Feb 20. |
3(0,0,0,3) | Details |
| 18524430 | Dabir S, Dabir P, Goswami K, Reddy MV: Prophylactic evaluation of recombinant extracellular superoxide dismutase of Brugia malayi in jird model. Vaccine. 2008 Jul 4;26(29-30):3705-10. Epub 2008 May 16. The immunoscreening of Brugia malayi adult cDNA library with pooled endemic normal sera identified several seroreactive clones including, EC-SOD which contained a 612 bp insert and showed significant nucleotide and deduced amino acid sequence homologies with superoxide dismutase (SOD) of other nematode parasites. Staining of native polyacrylamide gel for SOD activity of the expressed recombinant protein revealed that SOD activity inactivated by and peroxide but not by sodium azide, indicating presence of Cu/Zn-SOD. |
1(0,0,0,1) | Details |
| 8786975 | Takakura Y, Morita T, Fujikawa M, Hayashi M, Sezaki H, Hashida M, Borchardt RT: Characterization of LLC-PK1 kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs. Pharm Res. 1995 Dec;12(12):1968-72. METHODS: The association of 111In-labeled model protein drugs, bovine serum albumin (BSA), superoxide dismutase (SOD), soybean trypsin inhibitor (STI), and [Asu1.7]-eel calcitonin (Asu-ECT), with the monolayers of LLC-PK1 renal epithelial cells was characterized under various conditions. The association of STI decreased with increases in medium pH from 5.4 to 8.4 and was inhibited significantly by 2,4-dinitrophenol, sodium azide, cytochalasin B, and colchicine, suggesting that the cellular association involved endocytosis. |
1(0,0,0,1) | Details |
| 18975018 | Houghton EA, Nicholas KM: In vitro reactive species production by histatins and (I,II). J Biol Inorg Chem. 2009 Feb;14(2):243-51. Epub 2008 Oct 31. When the reactions are conducted in the presence of superoxide dismutase, the total peroxide produced is decreased, more so in the presence of the peptides (up to 50%), suggesting the intermediacy of in these reactions. On the other hand, the presence of sodium azide or traps for has no appreciable effect on the total peroxide production for the Cu-Hst systems. |
1(0,0,0,1) | Details |
| 10486142 | Totsune H, Ohno C, Kambayashi Y, Nakano M, Ushijima Y, Tero-Kubota S, Ikegami Y: Characteristics of chemiluminescence observed in the horseradish peroxidase- peroxide- system. Arch Biochem Biophys. 1999 Sep 15;369(2):233-42. Electrolysis of emitted light which peaked at 490 nm and was almost completely quenched by superoxide dismutase (SOD), while emission by bityrosine peaked at 530 nm. |
1(0,0,0,1) | Details |
| 9780311 | Aten RF, Kolodecik TR, Rossi MJ, Debusscher C, Behrman HR: treatment in vivo, but not in vitro, stimulates protein kinase C-activated production by nonsteroidogenic cells of the rat corpus luteum. Biol Reprod. 1998 Nov;59(5):1069-76. The TPA-induced response was cell number dependent and was virtually abolished by superoxide dismutase, freezing, or heating (95 degrees C for 5 min). The response to TPA and zymosan was inhibited by the /-oxidase inhibitor, diphenylene iodonium (ID50 = 5 microM for TPA), but not by the mitochondrial inhibitors, rotenone, or sodium azide. |
1(0,0,0,1) | Details |
| 8565117 | Tsou TC, Chen CL, Liu TY, Yang JL: Induction of in DNA by (III) plus peroxide and its prevention by scavengers. Carcinogenesis. 1996 Jan;17(1):103-8. Scavengers of reactive species markedly inhibited the formation of by CrCl3 plus H2O2; the inhibition effect was sodium azide > > Tris-HCl at an equal concentration. Moreover, an addition of catalase (2.2 U/ml) to the reaction mixture completely inhibited the formation of by CrCl3/H2O2, whereas only 22% of that formation was inhibited by superoxide dismutase (11 U/ml). |
1(0,0,0,1) | Details |
| 17302992 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: protects primary cultured cortical neurons against oxidative stress. Acta Pharmacol Sin. 2007 Mar;28(3):315-26. Endogenous antioxidant enzymes activity [superoxide dismutases (SOD), peroxidase (GSH-Px), and catalase (CAT)] and lipid peroxidation in cultured cortical neurons were evaluated using commercial kits. {3-[1 (p-chlorobenzyl)- 5-(isopropyl)-3-t-butylthiondol-2-yl]-2,2-dimethylpropanoic acid, Na} [MK886; 5 micromol/L; a noncompetitive inhibitor of proliferator-activated receptor (PPAR) alpha], bisphenol A diglycidyl ether (BADGE; 100 micromol/L; an antagonist of PPAR gamma), and cycloheximide (CHX; 30 micromol/L, an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
1(0,0,0,1) | Details |