Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
1702920 Arvidson B: Accumulation of mercury in brainstem nuclei of mice after retrograde axonal transport. Acta Neurol Scand. 1990 Oct;82(4):234-7.

Adult mice were injected intramuscularly in the region of the vibrissae muscles on the left side of the nose with a small volume of mercuric chloride dissolved in distilled water.
6(0,0,1,1) Details
8079358 Oliveira EM, Vassallo DV, Sarkis JJ, Mill JG: Mercury effects on the contractile activity of isolated heart muscle. . Toxicol Appl Pharmacol. 1994 Sep;128(1):86-91.


The toxic effects of HgCl2 (1, 2.5, 5, and 10 microM) were studied in isolated, isometrically contracting rat papillary muscles and frog ventricular strips.
2(0,0,0,2) Details
8031837 Picher M, Beliveau R, Potier M, Savaria D, Rousseau E, Beaudoin AR: Demonstration of an ectoATP-diphosphohydrolase (E.C.3.6.1.5.) in non-vascular smooth muscles of the bovine trachea. Biochim Biophys Acta. 1994 Jul 6;1200(2):167-74.

Sodium azide (20 mM), mercuric chloride (10 microM) and gossypol (35 microM) inhibit the enzyme activity by more than 45%.
2(0,0,0,2) Details
2057452 Nielsen JB, Andersen O: Methyl mercuric chloride toxicokinetics in mice. Pharmacol Toxicol. 1991 Mar;68(3):208-11.

II: Sexual differences in whole-body retention and deposition in blood, hair, skin, muscles and fat..
2(0,0,0,2) Details
1342826 Oliveira EM, Vassallo DV: Effects of mercury on the contractility of isolated rat cardiac muscle. . Braz J Med Biol Res. 1992;25(10):1037-40.


The effects of increasing concentrations of mercury (Hg2+) chloride (1, 2.5, 5 and 10 microM) were studied on isometrically contracting papillary muscles from female rats (Wistar, EPM strain) weighing 150 to 180 g.
1(0,0,0,1) Details
12927901 Moreira CM, Oliveira EM, Bonan CD, Sarkis JJ, Vassallo DV: Effects of mercury on myosin ATPase in the ventricular myocardium of the rat. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):269-75.


Mercury reduces twitch and tetanic force development in isolated rat papillary muscles, and a putative toxic effect on the contractile machinery has been suggested.
1(0,0,0,1) Details
8366987 Ishikawa I, Shikura N, Takada K, Sato Y: Changes of adenosine levels in the carotid artery, renal vein and inferior vena cava after glycerol or mercury injection in the rat. Nephron. 1993;64(4):605-8.


The increase in adenosine in the inferior vena cava was derived from the release from the acutely damaged muscles due to glycerol injection.
1(0,0,0,1) Details
9563171 Pathak SK, Bhowmik MK: The chronic toxicity of inorganic mercury in goats: clinical signs, toxicopathological changes and residual concentrations. Vet Res Commun. 1998 Feb;22(2):131-8.

Chronic mercury toxicity was induced in goats by administering mercuric chloride at 100 micrograms/ml in deionized drinking water offered ad libitum for 90 days.
The toxicity also induced nephrosis and tubular nephritis; centrilobular necrosis of liver; mild to moderate necrosis in spleen, intestine and lymph node; Zenker's degeneration of cardiac muscles; exudative pneumonia; and pial congestion, oedema and vacuolation in the brain.
1(0,0,0,1) Details