| Name | IgE |
|---|---|
| Synonyms | IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9485198 | Druet E, Praddaude F, Druet P, Dietrich G: Non-immunoglobulin serum proteins prevent the binding of IgG from normal rats and from rats with Th2-mediated autoimmune glomerulonephritis to various autoantigens including glomerular antigens. Eur J Immunol. 1998 Jan;28(1):183-92. Mercuric chloride (HgCl2) induces in Brown-Norway (BN) rats a Th2-dependent polyclonal B cell activation, a huge increase in serum IgE and IgG1 concentrations, the production of numerous autoantibodies and an autoantibody-mediated glomerulonephritis. |
81(1,1,1,1) | Details |
| 2964962 | Pelletier L, Pasquier R, Guettier C, Vial MC, Mandet C, Nochy D, Bazin H, Druet P: HgC12 induces T and B cells to proliferate and differentiate in BN rats. Clin Exp Immunol. 1988 Feb;71(2):336-42. Mercuric chloride induces in Brown-Norway (BN) rats an autoimmune disease characterized by the production of various autoantibodies and by a marked increase in the IgE serum concentration. |
81(1,1,1,1) | Details |
| 2515946 | Takafuji S, Suzuki S, Muranaka M, Miyamoto T: Influence of environmental factors on IgE production. . Ciba Found Symp. 1989;147:188-201; discussion 201-4. Epidemiological or experimental reports have shown that tobacco smoke, virus infection and mercuric chloride may enhance IgE production. |
38(0,1,1,8) | Details |
| 10886234 | Gorrie MJ, Qasim FJ, Whittle CJ, Gillespie KM, Szeto CC, Nicoletti F, Bolton EM, Bradley JA, Mathieson PW: Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat. Clin Exp Immunol. 2000 Jul;121(1):17-22. In susceptible rat strains, mercuric chloride (HgCl2) induces activation of Th2 cells, with enhanced expression of IL-4, polyclonal B cell activation and very high levels of circulating IgE. |
37(0,1,1,7) | Details |
| 12197880 | Macphee IA, Turner DR, Yagita H, Oliveira DB: The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28. Clin Exp Immunol. 2002 Sep;129(3):405-10. Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. |
34(0,1,1,4) | Details |
| 11485386 | Strenzke N, Grabbe J, Plath KE, Rohwer J, Wolff HH, Gibbs BF: Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. Toxicol Appl Pharmacol. 2001 Aug 1;174(3):257-63. Mercuric chloride (HgCl2) is an industrial agent known to cause autoimmune disorders and induce IgE synthesis, which plays a crucial role in the manifestation of allergic diseases. |
34(0,1,1,4) | Details |
| 15140057 | Hansson M, Abedi-Valugerdi M: Mercuric chloride induces a strong immune activation, but does not accelerate the development of dermal fibrosis in tight skin 1 mice. Scand J Immunol. 2004 May;59(5):469-77. In susceptible mice, mercuric chloride induces a systemic autoimmune disease characterized by increased serum levels of immunoglobulin (Ig) G1 and IgE, production of anti-nucleolar autoantibodies (ANolA) and formation of renal IgG deposits. |
32(0,1,1,2) | Details |
| 15720444 | Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, Depierre JW, Abedi-Valugerdi M: Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice. Immunology. 2005 Mar;114(3):428-37. In susceptible mice, mercuric chloride induces a systemic autoimmune response that is characterized by elevated serum levels of immunoglobulin G1 (IgG1) and immunoglobulin E (IgE), production of anti-nucleolar antibodies (ANolAs) and the formation of renal IgG deposits. |
32(0,1,1,2) | Details |
| 8766555 | al-Balaghi S, Moller E, Moller G, Abedi-Valugerdi M: Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB x NZW) F1 hybrids. Eur J Immunol. 1996 Jul;26(7):1519-26. It is well established that in susceptible mouse strains, chronic treatment with subtoxic doses of mercuric chloride (HgCl2) induces a systemic autoimmune disease, which is characterized by increased serum levels of IgG1 and IgE antibodies, by the production of anti-nucleolar antibodies and by the development of immune complex-mediated glomerulonephritis. |
32(0,1,1,2) | Details |
| 8918574 | Kiely PD, O'Brien D, Oliveira DB: Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996 Nov;106(2):280-5. Mercuric chloride (HgCl2) induces a T cell-dependent autoimmune syndrome in Brown-Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8+ and CD4+ T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. |
32(0,1,1,2) | Details |
| 10359893 | Dastych J, Walczak-Drzewiecka A, Wyczolkowska J, Metcalfe DD: Murine mast cells exposed to mercuric chloride release granule-associated N-acetyl-beta-D-hexosaminidase and secrete IL-4 and TNF-alpha. J Allergy Clin Immunol. 1999 Jun;103(6):1108-14. Mercuric chloride (HgCl2), is a xenobiotic, which induces autoimmune glomerulonephritis and stimulates polyclonal IgE production. |
32(0,1,1,2) | Details |
| 14738445 | Wu Z, Holwill SD, Oliveira DB: Desferrioxamine modulates chemically induced T helper 2-mediated autoimmunity in the rat. Clin Exp Immunol. 2004 Feb;135(2):194-9. A rise in interleukin (IL) 4-dependent immunoglobulin E (IgE) is a hallmark of the mercuric chloride (HgCl2)-induced Th2-mediated autoimmune syndrome in the Brown Norway (BN) rat, and one of the mediators in allergic asthma in human. |
32(0,1,1,2) | Details |
| 15379988 | Vinen CS, Turner DR, Oliveira DB: Resistance to re-challenge in the Brown Norway rat model of vasculitis is not always complete and may reveal separate effector and regulatory populations. Immunology. 2004 Oct;113(2):269-76. Administration of mercuric chloride to Brown Norway rats results in T helper type 2 (Th2)- dominated autoimmunity characterized by high immunoglobulin E (IgE) concentrations, the production of multiple IgG autoantibodies, including those to glomerular basement membrane (GBM), arthritis and caecal vasculitis. |
31(0,1,1,1) | Details |
| 1748484 | Saoudi A, Bellon B, de Kozak Y, Kuhn J, Vial MC, Thillaye B, Druet P: Prevention of experimental autoimmune uveoretinitis and experimental autoimmune pinealitis in Brown-Norway) F1 rats by HgCl2 injections. Immunology. 1991 Oct;74(2):348-54. Mercuric chloride (HgCl2) induces in Brown-Norway (BN) and Brown-Norway) F1 hybrid rats a transient autoimmune disease characterized by the production of various antibodies to self and non-self antigens and by a dramatic increase of serum IgE. |
31(0,1,1,1) | Details |
| 11975761 | Roether S, Rabbani H, Mellstedt H, Abedi-Valugerdi M: Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression. Scand J Immunol. 2002 May;55(5):493-502. Administration of mercuric chloride into susceptible rats and mice induces a systemic autoimmune disease, which is characterized by a T-cell-dependent polyclonal B-cell activation, an increase in serum levels of immunoglobulin (Ig) G1 and IgE, production of antibodies of different specificities and development of renal IgG deposits. |
31(0,1,1,1) | Details |
| 8686765 | Qasim FJ, Mathieson PW, Sendo F, Thiru S, Oliveira DB: Role of neutrophils in the pathogenesis of experimental vasculitis. . Am J Pathol. 1996 Jul;149(1):81-9. In the Brown-Norway rat, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by high IgE levels. |
7(0,0,1,2) | Details |
| 1572095 | Lillevang ST, Rosenkvist J, Andersen CB, Larsen S, Kemp E, Kristensen T: Single and combined effects of the analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol. 1992 May;88(2):301-6. This compound prevents autoimmune manifestations including proteinuria, serum IgE, and serum anti-laminin antibodies in a dose-dependent manner, as does cyclosporin A (CyA). |
2(0,0,0,2) | Details |
| 8082302 | Mathieson PW, Qasim FJ, Thiru S, Oldroyd RG, Oliveira DB: Effects of decomplementation with cobra venom factor on experimental vasculitis. Clin Exp Immunol. 1994 Sep;97(3):474-7. Mercuric chloride (HgCl2) induces autoimmunity in susceptible rat strains, with hyper-IgE, appearance of a number of autoantibodies, and widespread tissue injury, including necrotizing vasculitis in the gut. |
7(0,0,1,2) | Details |
| 2016536 | Ochel M, Vohr HW, Pfeiffer C, Gleichmann E: IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J Immunol. 1991 May 1;146(9):3006-11. |
7(0,0,1,2) | Details |
| 8958063 | Hodson D, Oliveira DB: The strain difference in the effect of mercuric chloride on antigen-triggered release from rat mast cells is not mediated via interferon-gamma. Immunology. 1996 Nov;89(3):463-7. Previous work has shown that in vitro exposure of Brown-Norway (BN) rat peritoneal mast cells to mercuric chloride (HgCl2) causes enhancement of subsequent mediator release induced by cross-linking of surface immunoglobulin E (IgE). |
6(0,0,1,1) | Details |
| 12505274 | Weatherill AR, Stang BV, O'Hara K, Koller LD, Hall JA: Investigating the onset of autoimmunity in A.SW mice following treatment with 'toxic oils'. Toxicol Lett. 2003 Jan 13;136(3):205-16. Additionally, mercuric chloride treated mice had elevated serum levels of IgG1, IgG2a and IgE and developed anti-nuclear and anti-collagen antibodies. |
6(0,0,1,1) | Details |
| 2509376 | Pietsch P, Vohr HW, Degitz K, Gleichmann E: Immunological alterations inducible by mercury compounds. Int Arch Allergy Appl Immunol. 1989;90(1):47-53. HgCl2 and gold thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains.. |
4(0,0,0,4) | Details |
| 7637329 | Kiely PD, Thiru S, Oliveira DB: Inflammatory polyarthritis induced by mercuric chloride in the Brown Norway rat. Lab Invest. 1995 Aug;73(2):284-93. In the Brown Norway (BN) rat, this is characterized by autoreactive T cells, high levels of total IgE, IgG autoantibodies, including anti-collagen types I and II, and tissue injury, including glomerulonephropathy and necrotizing vasculitis of the gut. |
4(0,0,0,4) | Details |
| 2384007 | Saoudi A, Bellon B, de Kozak Y, Vial MC, Thillaye B, Druet P: Inhibition of experimental autoimmune uveoretinitis by mercuric chloride injections in Brown Norway) F1 hybrid rats. Curr Eye Res. 1990;9 Suppl:135-8. Experimental autoimmune uveoretinitis (EAU), induced in (LEW X BN) F1 rats by immunization with S antigen (S-Ag) is T cell and antibody (ab) mediated and anti-S-Ag IgE ab have been involved in the occurrence of ocular lesions. (LEW X BN) F1 rats repeatedly injected with HgCl2 develop an autoimmune disease characterized by numerous auto-ab and a high increase of serum IgE level. |
2(0,0,0,2) | Details |
| 10720764 | White KL, David DW, Butterworth LF, Klykken PC: Assessment of autoimmunity-inducing potential using the brown Norway rat challenge model. Toxicol Lett. 2000 Mar 15;112-113:443-51. A unique characteristic of the BN rat model is that the increase in IgE is self-limiting with levels eventually returning to normal. Two compounds known to produce autoimmunity, mercuric chloride and D-penicillamine, were studied as were, trichloroethylene and silicone gel, two agents suspected of inducing autoimmune disease. |
2(0,0,0,2) | Details |
| 16237113 | Zheng Y, Gallucci S, Gaughan JP, Gross JA, Monestier M: A role for B cell-activating factor of the TNF family in chemically induced autoimmunity. J Immunol. 2005 Nov 1;175(9):6163-8. After exposure to subtoxic doses of heavy metals such as mercury, H-2s mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE. |
2(0,0,0,2) | Details |
| 14616778 | Haggqvist B, Hultman P: Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response. Clin Exp Immunol. 2003 Nov;134(2):202-9. HgIA has many characteristics of a Th2 type of reaction, including a strong increase of IgE, but disease induction is critically dependent on the Th1 cytokine IFN-gamma. |
2(0,0,0,2) | Details |
| 11867563 | Wu Z, Turner DR, Oliveira DB: Antioxidants inhibit mercuric chloride-induced early vasculitis. . Int Immunol. 2002 Mar;14(3):267-73. The aim of this study was to determine whether administration of antioxidants inhibits HgCl (2)-induced early vasculitis in vivo, and, if so, to examine whether modulation of the oxidative/antioxidative balance influences IgE and IL-4 expression by mast cells in situ. |
2(0,0,0,2) | Details |
| 17015760 | Vinay DS, Kim JD, Kwon BS: Amelioration of mercury-induced autoimmunity by 4-1BB. . J Immunol. 2006 Oct 15;177(8):5708-17. In certain strains of mice, subtoxic doses of HgCl2 (mercuric chloride; mercury) induce a complex autoimmune condition characterized by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE Abs, and deposition of renal immune complexes. 4-1BB is an important T cell costimulatory molecule that has been implicated in T cell proliferation and cytokine production, especially production of IFN-gamma. |
83(1,1,1,3) | Details |
| 9022032 | Wolfreys K, Oliveira DB: Alterations in intracellular reactive species generation and redox potential modulate mast cell function. Eur J Immunol. 1997 Jan;27(1):297-306. The administration of mercuric chloride (HgCl2), gold compounds, or D-penicillamine to Brown Norway (BN) rats causes a T helper (Th) 2 cell-associated autoimmune syndrome characterized by the production of a number of autoantibodies, marked elevation of serum IgE concentration, and tissue injury in the form of a vasculitis and arthritis. |
83(1,1,1,3) | Details |
| 10447925 | Szeto C, Gillespie KM, Mathieson PW: Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-gamma. Scand J Immunol. 1999 Aug;50(2):195-201. Mercuric chloride induces autoimmunity in Brown Norway rats with polyclonal B-cell activation, hyper-IgE and multiple autoantibodies. |
83(1,1,1,3) | Details |
| 9469417 | Bagenstose LM, Salgame P, Monestier M: IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J Immunol. 1998 Feb 15;160(4):1612-7. In genetically susceptible H-2s mice, subtoxic doses of mercuric chloride (HgCl2) induce a complex autoimmune syndrome characterized by the production of anti-nucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1 and IgE Abs, and renal Ig deposits. |
82(1,1,1,2) | Details |
| 10886398 | Szeto C, Gillespie KM, Mathieson PW: Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance. Immunology. 2000 Jun;100(2):217-24. Further, the type 2 response induced in BN rats by mercuric chloride was markedly attenuated when rats were pretreated with levamisole: there was a 2-log reduction in maximum serum IgE level and marked attenuation of IL-4 gene upregulation. |
82(1,1,1,2) | Details |
| 9764596 | Bagenstose LM, Salgame P, Monestier M: Mercury-induced autoimmunity in the absence of IL-4. . Clin Exp Immunol. 1998 Oct;114(1):9-12. In susceptible H-2S mice, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by production of anti-nucleolar antibodies (ANoA) and increased serum levels of IgG1 and IgE antibodies. |
82(1,1,1,2) | Details |
| 2139074 | Tournade H, Pelletier L, Pasquier R, Vial MC, Mandet C, Druet P: D-penicillamine-induced autoimmunity in Brown-Norway rats. J Immunol. 1990 Apr 15;144(8):2985-91. These manifestations are quite similar to those observed in mercuric chloride (HgCl2)-induced autoimmunity. A transient increase in the number of spleen cells, affecting B cells and CD4+ T cells, and an increase in serum IgE concentration, previously reported in HgCl2-induced autoimmunity, were observed during DP treatment. |
1(0,0,0,1) | Details |
| 8497865 | Hua J, Pelletier L, Berlin M, Druet P: Autoimmune glomerulonephritis induced by mercury vapour exposure in the Brown Norway rat. Toxicology. 1993 Apr 30;79(2):119-29. Subcutaneous injections of mercuric chloride induce an autoimmune glomerulonephritis with both granular and linear IgG deposits along the glomerular capillary wall and proteinuria. Increase in serum IgE concentration is the hallmark of this disease. |
1(0,0,0,1) | Details |
| 18432732 | Badou A, Saoudi A, Dietrich G, Druet E, Druet P, Pelletier L: Mercuric chloride-induced autoimmunity. Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.15. This unit describes methods for inducing autoimmune disease in Brown Norway rats through HgCl (2) injections as well for assessing parameters that characterize the disease by serum IgE concentration assays, anti-laminin antibody measurement, and renal immunofluorescence studies to detect autoantibodies. |
1(0,0,0,1) | Details |
| 9693280 | Johansson U, Hansson-Georgiadis H, Hultman P: The genotype determines the B cell response in mercury-treated mice. Int Arch Allergy Immunol. 1998 Aug;116(4):295-305. The BALB/C strain developed a slight, transient B cell activation dominated by IgG1 and IgE, and antinuclear antibodies (ANA). METHODS: During 4-7 weeks of subcutaneous mercuric chloride injections, the number of B cells and the expression of cell surface activation and proliferation markers was monitored by flow cytometry. |
1(0,0,0,1) | Details |
| 18075863 | de Vos G, Abotaga S, Liao Z, Jerschow E, Rosenstreich D: Selective effect of mercury on Th2-type cytokine production in humans. Immunopharmacol Immunotoxicol. 2007;29(3-4):537-48. Mercury induces autoimmune disease and increases IL-4 production and IgE levels in certain rodent strains. Human peripheral blood mononuclear cells (PBMC) were incubated with PMA/ionomycin or Con A in the presence or absence of methyl mercury (CH (3) Hg) or mercuric chloride (HgCl (2)). |
1(0,0,0,1) | Details |
| 7664789 | Oliveira DB, Gillespie K, Wolfreys K, Mathieson PW, Qasim F, Coleman JW: Compounds that induce autoimmunity in the brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression. Eur J Immunol. 1995 Aug;25(8):2259-64. Brown Norway (BN) rats given mercuric chloride (HgCl2), gold (Au) salts or D-penicillamine develop a T helper 2 (Th2) cell-mediated autoimmune syndrome. Incubation of BN rat peritoneal mast cells with HgCl2 enhanced the release of in response to IgE cross-linking agents. |
1(0,0,0,1) | Details |
| 7589090 | Kiely PD, Gillespie KM, Oliveira DB: Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Eur J Immunol. 1995 Oct;25(10):2899-906. In two separate experiments, OXP significantly enhanced unstimulated levels of splenic interleukin-4 (IL-4) mRNA (median 62%, of an artificial IL-4 mRNA construct, vs. 36.5% in controls) and in one experiment, exaggerated the total IgE response to HgCl2. |
1(0,0,0,1) | Details |
| 8102566 | van Vliet E, Uhrberg M, Stein C, Gleichmann E: MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int Arch Allergy Immunol. 1993;101(4):392-401. Systemic treatment of susceptible mouse strains with HgCl2 is known to induce elevated serum concentrations of IgG1, IgG2A, and IgE, formation of antinuclear (ANA) and antinucleolar autoantibodies (ANolA), and immune glomerulonephritis. |
1(0,0,0,1) | Details |
| 12490134 | Jin GB, Inoue S, Urano T, Cho S, Ouchi Y, Cyong JC: Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice. Toxicol Appl Pharmacol. 2002 Dec 1;185(2):98-110. Furthermore, serum titers of IgE and IgG1 were significantly elevated in the MT-immunized plus HgCl2 treatment group compared with those in the HgCl2 treatment group. Mercuric chloride (HgCl2) is an industrial agent with toxic effects on the immune system, kidney, lung, and nervous tissue, but little is known about its effect on bone. |
1(0,0,0,1) | Details |
| 12874254 | Zheng Y, Monestier M: Inhibitory signal override increases susceptibility to mercury-induced autoimmunity. J Immunol. 2003 Aug 1;171(3):1596-601. After exposure to subtoxic doses of heavy metals such as mercury, H-2 (s) mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE. In susceptible mice treated with mercuric chloride (HgCl (2)), administration of a blocking anti-CTLA-4 Ab resulted in a further increase in anti-nucleolar autoantibodies and in total serum IgG1 levels. |
1(0,0,0,1) | Details |
| 12848997 | Fournie GJ, Saoudi A, Druet P, Pelletier L: Th2-type immunopathological manifestations induced by mercury or gold salts in the rat: signal transduction pathways, cellular mechanisms and genetic control. Autoimmun Rev. 2002 Aug;1(4):205-12. Heavy metals induce various immunopathological disorders including an increase in serum IgE concentration in predisposed humans. |
1(0,0,0,1) | Details |
| 3052091 | Aten J, Bosman CB, Rozing J, Stijnen T, Hoedemaeker PJ, Weening JJ: Mercuric chloride-induced autoimmunity in the brown Norway rat. Am J Pathol. 1988 Oct;133(1):127-38. B lymphocyte activation involved mainly the IgG1 and IgE isotypes. |
1(0,0,0,1) | Details |
| 11439166 | Abedi-Valugerdi M, Hansson M, Moller G: Genetic control of resistance to mercury-induced immune/autoimmune activation. Scand J Immunol. 2001 Jul-Aug;54(1-2):190-7. Previous studies have shown that genetic factors control the susceptibility to mercury-induced immunoglobulin (Ig) G1 antibody formation, IgE synthesis, renal IgG deposits and antinucleolar autoantibodies (ANolA) production in the susceptible mice. |
1(0,0,0,1) | Details |
| 3140125 | Vendeville B, Baran D, Imbert F, Kuhn J, Vial MC, Hibbard J, Paris M, Mahieu P, Druet P: Plasma exchange in a rat model of autoimmune glomerulonephritis. . Nephrol Dial Transplant. 1988;3(4):405-11. Serum IgE, characteristically elevated in HgCl2-treated rats, is also markedly diminished in exchanged rats. |
1(0,0,0,1) | Details |
| 10651952 | MacPhee IA, Turner DR, Oliveira DB: The role of endogenous steroid hormones in the generation of T helper 2-mediated autoimmunity in mercuric chloride-treated Brown-Norway rats. Immunology. 2000 Jan;99(1):141-6. In both groups of Adx animals there was a delay in the production of immunoglobulin E (IgE) and serum concentrations on day 9 were marginally lower (P = 0.035, repeated measures ANOVA). |
1(0,0,0,1) | Details |
| 7923887 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB: Use of methyl prednisolone and antioxidants in mercuric chloride-induced experimental vasculitis. Clin Exp Immunol. 1994 Oct;98(1):66-70. Serial blood samples were taken for anti-MPO and IgE antibodies, which were assayed by ELISA. |
1(0,0,0,1) | Details |
| 8469923 | Dubey D, Kuhn J, Vial MC, Druet P, Bellon B: Anti-interleukin-2 receptor monoclonal antibody therapy supports a role for Th1-like cells in HgCl2-induced autoimmunity in rats. Scand J Immunol. 1993 Apr;37(4):406-12. Increase in major histocompatibility complex class II molecule expression on B cells concomitant with enhancement of serum IgE concentration supports the involvement of the T helper 2 (Th2)-like subset in the induction of the disease. |
1(0,0,0,1) | Details |
| 1914225 | Dubey C, Bellon B, Hirsch F, Kuhn J, Vial MC, Goldman M, Druet P: Increased expression of class II major histocompatibility complex molecules on B cells in rats susceptible or resistant to HgCl2-induced autoimmunity. Clin Exp Immunol. 1991 Oct;86(1):118-23. Administration of HgCl2 to the susceptible Brown-Norway (BN) rats induces an autoimmune disease characterized by a T-dependent polyclonal activation of B cells responsible for a dramatic increase in serum IgE concentration. |
1(0,0,0,1) | Details |
| 7853852 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB: Cyclosporin A exacerbates mercuric chloride-induced vasculitis in the brown Norway rat. Lab Invest. 1995 Feb;72(2):183-90. Serial blood samples were taken for anti-glomerular basement membrane, anti-MPO, and IgE antibody levels. |
1(0,0,0,1) | Details |
| 9218838 | Doth M, Fricke M, Nicoletti F, Garotta G, Van Velthuysen ML, Bruijn JA, Gleichmann E: Genetic differences in immune reactivity to mercuric chloride (HgCl2): immunosuppression of H-2d mice is mediated by interferon-gamma (IFN-gamma). Clin Exp Immunol. 1997 Jul;109(1):149-56. Upon treatment with HgCl2, H-2s mice, such as B10.S, develop an activation of B lymphocytes that depends, at least partially, on activation of T helper type 2 (Th2) cells and results in increased serum levels of IgG1 and IgE, appearance of IgG autoantibodies, and development of immune glomerulonephritis and vasculitis. |
1(0,0,0,1) | Details |
| 8450183 | Shenker BJ, Berthold P, Rooney C, Vitale L, DeBolt K, Shapiro IM: Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. Immunopharmacol Immunotoxicol. 1993 Jan;15(1):87-112. In comparison, B-cell expression of the low affinity IgE receptor and the transferrin receptor were significantly reduced. |
1(0,0,0,1) | Details |
| 8658504 | Heo Y, Parsons PJ, Lawrence DA: Lead differentially modifies cytokine production in vitro and in vivo. Toxicol Appl Pharmacol. 1996 May;138(1):149-57. Additionally, the plasma IL-4 and IgE levels of Pb-exposed mice were increased, and the plasma IFN gamma levels were significantly lowered in the absence of any additional exogenous antigen. |
1(0,0,0,1) | Details |
| 7503730 | Woolfson RG, Qasim FJ, Thiru S, Oliveira DB, Neild GH, Mathieson PW: contributes to tissue injury in mercuric chloride-induced autoimmunity. Biochem Biophys Res Commun. 1995 Dec 14;217(2):515-21. |
0(0,0,0,0) | Details |
| 2137255 | Pelletier L, Rossert J, Pasquier R, Vial MC, Druet P: Role of CD8+ T cells in mercury-induced autoimmunity or immunosuppression in the rat. Scand J Immunol. 1990 Jan;31(1):65-74. In Brown-Norway (BN) rats mercuric chloride induces an autoimmune disease characterized by an increase in serum IgE concentration, and by the production of anti-glomerular basement membrane antibodies responsible for a glomerulonephritis with a heavy proteinuria. (i) This disease results from a B-cell polyclonal activation probably due to frequent anti-class II T cells. (ii) The self limitation observed in this model is associated with both a decrease in the frequency of anti-class II T cells and the emergence of CD8+ T cells able to suppress these autoreactive T cells. (iii) In Lewis (LEW) rats which do not develop autoimmunity, HgCl2 provokes the appearance of non-antigen-specific CD8+ T cells responsible for a depression of T-cell functions. |
0(0,0,0,0) | Details |
| 2015703 | Rossi F, Bellon B, Vial MC, Druet P, Kazatchkine MD: Beneficial effect of human therapeutic intravenous immunoglobulins (IVIg) in mercuric-chloride-induced autoimmune disease of Brown-Norway rats. Clin Exp Immunol. 1991 Apr;84(1):129-33. Administration of HgCl2 to the susceptible Brown-Norway (BN) strain of rats induces an autoimmune disease characterized by polyclonal B cell activation, increased serum levels of IgE and the occurrence of anti-glomerular basement membrane antibody-mediated glomerulonephritis. |
2(0,0,0,2) | Details |
| 15996188 | Abedi-Valugerdi M, Nilsson C, Zargari A, Gharibdoost F, DePierre JW, Hassan M: Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice. Clin Exp Immunol. 2005 Aug;141(2):238-47. Following treatment of mouse strains resistant [DBA/2 (H-2 (d))] or susceptible [SJL (H-2 (s))] to such autoimmunity with mercuric chloride and/or LPS or with physiological saline alone (control), their immune/autoimmune responses were monitored. Resistant DBA/2 mice were rendered susceptible to mercury-induced autoimmunity by co-administration of LPS, exhibiting pronounced increases in the synthesis of IgG1 and IgE, high titres of IgG1 deposits in the kidneys and elevated circulating levels of IgG1 antibodies of different specificities. |
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| 15032693 | Wu Z, MacPhee IA, Oliveira DB: Reactive species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. Curr Pharm Des. 2004;10(8):899-913. Cells secreting interleukin-4 (IL-4) are known as Th2 cells and promote humoral immune responses, in particular the production of IgE and IgG4 (human) or IgG1 (rodents). Study of an animal model of Th2-driven autoimmunity (mercuric chloride-induced autoimmunity in Brown Norway rats) has yielded insights into a possible role for oxidant stress in the generation of Th-2 driven autoimmune responses. |
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| 9182889 | Qasim FJ, Thiru S, Gillespie K: Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: support for a role for Th2 cell activity. Clin Exp Immunol. 1997 Jun;108(3):438-45. DP, gold salts and mercuric chloride (HgCl2) are known to induce Th2-dominated autoimmune syndromes in genetically susceptible rodent strains, and we have demonstrated recently that HgCl2 up-regulates messenger RNA (mRNA) for IL-4 in the Brown Norway (BN) rat. Tissue injury was assessed macroscopically and histologically on day 5 and day 15 after the start of injections with gold, DP or HgCl2, serum titres of IgE and presence of anti-MPO antibodies were determined using ELISA, and a semi-quantitative assay using reverse transcription-polymerase chain reaction was used to assay the level of mRNA for IL-4 in spleen and caecum. |
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| 7704901 | van der Meide PH, Groenestein RJ, de Labie MC, Aten J, Weening JJ: Susceptibility to mercuric chloride-induced glomerulonephritis is age-dependent: study of the role of IFN-gamma. Cell Immunol. 1995 Apr 15;162(1):131-7. The repeated administration of low-dose HgCl2 to brown Norway (BN) rats induces an autoimmune syndrome which is characterized by polyclonal B cell activation, high-level synthesis of IgE and IgG1, and massive proteinuria. |
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| 17672870 | Ekerfelt C, Andersson M, Olausson A, Bergstrom S, Hultman P: Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis: HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H/HeN mice. Clin Exp Immunol. 2007 Oct;150(1):189-97. Epub 2007 Aug 2. Arthritis severity was evaluated by histology, spirochaetal load determined by Borrelia culture, IgG2a- and IgE-levels analysed by enzyme-linked immunosorbemt assay (ELISA) and cytokine-secreting cells detected by enzyme-linked immunospot (ELISPOT). |
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| 15728528 | Zheng Y, Jost M, Gaughan JP, Class R, Coyle AJ, Monestier M: ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity. J Immunol. 2005 Mar 1;174(5):3117-21. After exposure to subtoxic doses of heavy metals such as mercury, H-2 (s) mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE. |
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| 18314309 | Martinsson K, Carlsson L, Kleinau S, Hultman P: The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity. J Autoimmun. 2008 Aug;31(1):22-9. Epub 2008 Mar 7. Hg-treated FcgammaRIIB (-/-) mice showed an increase of both serum IgG1 and IgE compared to wt mice. |
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| 19203382 | Inman RD, Chiu B: Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis. Arthritis Res Ther. 2009;11(1):R19. Epub 2009 Feb 9. In the present study, we examine an environmental toxin, mercuric chloride (HgCl2), as a modulator of this innate resistance to arthritis. Mercury exposure was also associated with marked enhancement in IgE levels and an alteration in IgG2a/IgG1 ratio, reflecting a Th2 shift. |
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| 8666905 | Biancone L, Andres G, Ahn H, Lim A, Dai C, Noelle R, Yagita H, De Martino C, Stamenkovic I: Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease. J Exp Med. 1996 Apr 1;183(4):1473-81. In contrast, two anti-CD2 antibodies that have been shown to induce immunosuppression of Th1-mediated events exacerbated the autoantibody response and augmented IgG1, IgE, and IL-4 production, transforming a mild mesangial glomerulopathy into a severe systemic immune complex disease. |
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| 8643162 | Vendeville B, Baran D, Gascon-Barre M: Effects of and cyclosporin A on HgCl2-induced autoimmunity in brown Norway rats. Nephrol Dial Transplant. 1995 Nov;10(11):2020-6. The following markers of disease activity were evaluated: mortality, peak proteinuria, serum IgE concentrations, and renal immunoglobulin deposition. BACKGROUND: Mercuric chloride (HgCl2) induces a lymphoproliferative disorder and autoimmune glomerulonephritis in Brown Norway (BN) rats. |
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| 9565363 | Albers R, de Heer C, Bol M, Bleumink R, Seinen W, Pieters R: Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgCl2. Eur J Immunol. 1998 Apr;28(4):1233-42. Injection of HgCl2 on the other hand, reduced the number of IFN-gamma-producing cells, induced accumulation of B cells and CD4+ and CD8+ T cells, enhanced IgG1 and IgE production to TNP-OVA, and primed for secondary IgG1 and IgE production as well as for DTH reactions. |
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