Protein Information

Name CFTR
Synonyms ABC35; ABCC 7; ABCC7; ATP binding cassette transporter sub family C member 7; CF; CFTR; CFTR/MRP; MRP 7…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
16432888 Ratner MA, Decker SE, Aller SG, Weber G, Forrest JN Jr: Mercury toxicity in the shark (Squalus acanthias) rectal gland: apical CFTR chloride channels are inhibited by mercuric chloride. J Exp Zool A Comp Exp Biol. 2006 Mar 1;305(3):259-67.
84(1,1,1,4) Details
16236827 Weber GJ, Mehr AP, Sirota JC, Aller SG, Decker SE, Dawson DC, Forrest JN Jr: Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102. Am J Physiol Cell Physiol. 2006 Mar;290(3):C793-801. Epub 2005 Oct 19.

In oocytes expressing sCFTR, FOR + IBMX mean stimulated Cl (-) conductance was inhibited 69% by 1 microM mercuric chloride and 78% by 5 microM mercuric chloride (IC (50) of 0.8 microM).
3(0,0,0,3) Details