| Name | delta aminolevulinic acid dehydratase |
|---|---|
| Synonyms | ALAD; ALADH; Aminolevulinate dehydratase; Delta aminolevulinate dehydratase; Delta aminolevulinic acid dehydratase; PBGS; Porphobilinogen synthase; Porphyria acute hepatic… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8884872 | Emanuelli T, Rocha JB, Pereira ME, Porciuncula LO, Morsch VM, Martins AF, Souza DO: Effect of mercuric chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice. Pharmacol Toxicol. 1996 Sep;79(3):136-43. In the present investigation we studied the inhibitory effect of mercuric chloride treatment (3 days with 2.3 or 4.6 mg/kg HgCl2, sc) in mice on cerebral, renal and hepatic delta-aminolevulinate dehydratase (ALA-D) activity, and a possible reversal of the effect of mercury by dimercaprol (0.25 mmol/kg, 24 hr after the last mercury injection). |
37(0,1,2,2) | Details |
| 12595158 | Farina M, Brandao R, Lara FS, Soares FA, Souza DO, Rocha JB: Mechanisms of the inhibitory effects of and mercury on the activity of delta-aminolevulinate dehydratase from mouse liver, kidney and brain. Toxicol Lett. 2003 Mar 20;139(1):55-66. The main goal of this study was to investigate the simultaneous in vitro effects of selenite (Se (4+)) and mercuric chloride (Hg (2+)) on the activity of hepatic, renal and cerebral delta-aminolevulinate dehydratase (delta-ALA-D) of adult male mice (Swiss albino). |
7(0,0,1,2) | Details |
| 12499120 | Farina M, Brandao R, de Lara FS, Pagliosa LB, Soares FA, Souza DO, Rocha JB: Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and selenite. Toxicology. 2003 Mar 3;184(2-3):179-87. |
7(0,0,1,2) | Details |
| 17490898 | Peixoto NC, Kratz CP, Roza T, Morsch VM, Pereira ME: Effects of HgCl2 on porphobilinogen-synthase (E.C. 4.2.1.24) activity and on mercury levels in rats exposed during different precocious periods of postnatal life. Cell Biol Int. 2007 Sep;31(9):1057-62. Epub 2007 Mar 28. |
2(0,0,0,2) | Details |
| 15147922 | Perottoni J, Lobato LP, Silveira A, Rocha JB, Emanuelli T: Effects of mercury and selenite on delta-aminolevulinate dehydratase activity and on selected oxidative stress parameters in rats. Environ Res. 2004 Jun;95(2):166-73. |
1(0,0,0,1) | Details |
| 16841248 | Brandao R, Santos FW, Zeni G, Rocha JB, Nogueira CW: DMPS and induced renal toxicity in mice exposed to mercury. Biometals. 2006 Aug;19(4):389-98. Acute effects of mercuric chloride (HgCl2) were evaluated on mice. At 24 h after the last HgCl2 injection, blood, liver and kidney samples were collected. delta-Aminolevulinate dehydratase (delta-ALA-D) and Na+, K- (+) ATPase activities, thiobarbituric acid-reactive substances (TBARS), non-protein thiols (NPSH) and concentrations were evaluated. |
1(0,0,0,1) | Details |
| 7624881 | Rocha JB, Pereira ME, Emanuelli T, Christofari RS, Souza DO: Effect of treatment with mercury and lead during the second stage of rapid postnatal brain growth on delta-aminolevulinic acid dehydratase (ALA-D) activity in brain, liver, kidney and blood of suckling rats. Toxicology. 1995 Jun 26;100(1-3):27-37. |
2(0,0,0,2) | Details |
| 11701233 | Rocha JB, Rocha LK, Emanuelli T, Pereira ME: Effect of mercuric chloride and lead treatment during the second stage of rapid post-natal brain growth on the behavioral response to chlorpromazine and on delta-ALA-D activity in weaning rats. Toxicol Lett. 2001 Dec 15;125(1-3):143-50. The effects of these metals on the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D) were also investigated. |
1(0,0,0,1) | Details |
| 14615064 | Peixoto NC, Roza T, Flores EM, Pereira ME: Effects of zinc and cadmium on HgCl2-delta-ALA-D inhibition and Hg levels in tissues of suckling rats. Toxicol Lett. 2003 Dec 15;146(1):17-25. The effects of CdCl2 and ZnCl2 pretreatments on the inhibition of delta-ALA-D (delta-aminolevulinic acid dehydratase) activity and Hg contents in liver and kidneys of suckling rats intoxicated with HgCl2 were investigated. |
1(0,0,0,1) | Details |
| 17516994 | Augusti PR, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graca DL, Emanuelli T: Effect of on nephrotoxicity induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):398-402. HgCl (2)-induced inhibition of delta-aminolevulinate dehydratase activity (approximately 35%) and increase of lipid peroxidation in kidney (approximately 37%) were prevented by |
1(0,0,0,1) | Details |
| 16964587 | Brandao R, Santos FW, Farina M, Zeni G, Bohrer D, Rocha JB, Nogueira CW: Antioxidants and metallothionein levels in mercury-treated mice. Cell Biol Toxicol. 2006 Nov;22(6):429-38. Epub 2006 Sep 11. Mice received a single dose of mercuric chloride (HgCl2, 4.6 mg/kg, subcutaneously) for three consecutive days. The results demonstrated that HgCl2 exposure significantly inhibited delta-aminolevulinate dehydratase (delta-ALA-D) activity in liver and only DMPS treatment prevented the inhibitory effect. |
1(0,0,0,1) | Details |
| 15755313 | Roza T, Peixoto NC, Welter A, Flores EM, Pereira ME: 2,3-Dimercapto- does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):302-8. The present study examined the effects of HgCl2 exposure (five doses of 5.0 mg/kg between ages 8 to 12 days) on physiological parameters, on porphobilinogen synthase activity, and on mercury content in liver, kidneys and brain from suckling rats. |
1(0,0,0,1) | Details |
| 17881112 | Augusti PR, Conterato GM, Somacal S, Sobieski R, Spohr PR, Torres JV, Charao MF, Moro AM, Rocha MP, Garcia SC, Emanuelli T: Effect of on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food Chem Toxicol. 2008 Jan;46(1):212-9. Epub 2007 Aug 14. |
0(0,0,0,0) | Details |