Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name maneb
CAS

Reference List

PubMed Abstract RScore(About this table)
18985485 Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C: The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res. 2008 Oct;42(10):849-62.

A significant increase in myeloperoxidase (MPO), superoxide dismutase (SOD), nitric oxide, iNOS expression and lipid peroxidation (LPO) was observed in PMNs of MB- and/or PQ-treated animals, while catalase and glutathione S-transferase (GST) activities were attenuated.
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16510128 Patel S, Singh V, Kumar A, Gupta YK, Singh MP: Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18. Epub 2006 Feb 28.

A significant increase in catalase, glutathione S-transferase and lipid peroxidation in the striatum was found following 3, 6 and 9 weeks of co-treatment as compared with individual treatment or controls.
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17597214 Domico LM, Cooper KR, Bernard LP, Zeevalk GD: Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology. 2007 Nov;28(6):1079-91. Epub 2007 May 22.

Previous in vitro studies in our laboratory have shown that mancozeb (MZ) and maneb (MB), both widely used EBDC fungicides, are equipotent neurotoxicants that produce cell loss in mesencephalic dopaminergic and GABAergic cells after an acute 24h exposure.
Inhibition of intracellular catalase with aminotriazole had little effect on H (2) O (2) generation, whereas exogenously added catalase significantly reduced H (2) O (2) production, demonstrating a large extracellular contribution to ROS generation.
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18585479 Falfushinska HI, Romanchuk LD, Stolyar OB: Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Sep;148(3):223-9. Epub 2008 Jun 8.


Catalase activity, superoxide anion and metallothionein levels were the same in both groups.
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