Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name maneb
CAS

Reference List

PubMed Abstract RScore(About this table)
3868355 Savolainen K, Hervonen H: Dithiocarbamate fungicides decrease histochemical reactivity of cholinesterases in the gut wall of the rat. Arch Toxicol Suppl. 1985;8:272-6.

Maneb, ETU and zineb showed consistent decrease in the reactivity for the AChE (+ +) and for the nsChE (+ +).
9(0,0,1,4) Details
15261450 Jarrard HE, Delaney KR, Kennedy CJ: Impacts of carbamate pesticides on olfactory neurophysiology and cholinesterase activity in coho salmon (Oncorhynchus kisutch). Aquat Toxicol. 2004 Aug 10;69(2):133-48.


Pesticides such as carbamates are known to affect fundamental physiological systems (such as the enzyme acetylcholinesterase (AChE)), and have been shown to affect salmonid olfactory-mediated behaviors.
3(0,0,0,3) Details
18585479 Falfushinska HI, Romanchuk LD, Stolyar OB: Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Sep;148(3):223-9. Epub 2008 Jun 8.


The untreated animals from the polluted site had lower Cu,Zn- and Mn-superoxide dismutase (SOD) and acetylcholinesterase activity, the levels of lipid peroxidation products (TBARS) and protein carbonyls in the liver and vitellogenin-like proteins (Vtg-LP) in the serum, but higher levels of glutathione in the liver in comparison with untreated frogs from the reference site.
2(0,0,0,2) Details
10641187 Kackar R, Srivastava MK, Raizada RB: Assessment of toxicological effects of mancozeb in male rats after chronic exposure. Indian J Exp Biol. 1999 Jun;37(6):553-9.


Mancozeb has produced significant enzymatic changes in the activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE) throughout the period of study in a dose dependent manner.
1(0,0,0,1) Details