Protein Information

Name SVAS
Synonyms ELN; WS; WBS; Elastin; Elastin precursor; SVAS; Tropoelastin; Elastins…

Compound Information

Name maneb
CAS

Reference List

PubMed Abstract RScore(About this table)
2136049 Beck SL: Prenatal and postnatal assessment of Maneb-exposed CD-1 mice. Reprod Toxicol. 1990;4(4):283-90.

Skeletons of CD-1 mice exposed in utero during days 6 to 15 of gestation by gavage of their dams with 1200 mg/kg/day of Maneb in 1.0% carboxymethylcellulose (CMC), were examined between 60 and 65 days postnatal (DPN) for the 88 variants of the skeletal variant assay system (SVAS).
6(0,0,1,1) Details
8446928 Beck SL: Additional endpoints and overview of a mouse skeletal variant assay for detecting exposure to teratogens. Teratology. 1993 Feb;47(2):147-57.

Prenatal exposure to a teratogenic dose at a sensitive time enabled detection of 10 of 14 teratogen regimes by alterations in frequency or severity of a substantial number of the 88 variants in the Skeletal Variant Assay System (SVAS) screen when examined at 60-65 days post natal (DPN).
These included 2,4,5-T (245T), Trifluralin (TFL), Maneb (MNB), Decamethrin (DMT), Acetazolamide (ACZM) either at 8 days post-coitus (DPC) or days 9-11 PC, trypan blue (TB), or 5' Bromodeoxyuridine (BUDR) on either 7 DPC, 8 DPC, or 9 DPC.
1(0,0,0,1) Details