Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name maneb
CAS

Reference List

PubMed Abstract RScore(About this table)
8516783 Siddiqui A, Ali B, Srivastava SP: Effect of mancozeb on hepatic glutathione S-transferase in rat. Toxicol Lett. 1993 Jun;68(3):301-5.

2(0,0,0,2) Details
16510128 Patel S, Singh V, Kumar A, Gupta YK, Singh MP: Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18. Epub 2006 Feb 28.

The involvement of cytochrome P4502E1 and glutathione S-transferases A4-4 enzymes in the detoxification of several pesticides such as atrazine, fenamirol, organophosphorous insecticide parathion, methoxychlor, diethyl dithiocarbamate and paraquat has been known.
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18985485 Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C: The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res. 2008 Oct;42(10):849-62.

A significant increase in myeloperoxidase (MPO), superoxide dismutase (SOD), nitric oxide, iNOS expression and lipid peroxidation (LPO) was observed in PMNs of MB- and/or PQ-treated animals, while catalase and glutathione S-transferase (GST) activities were attenuated.
1(0,0,0,1) Details
9801766 Fabra A, Angelini J, Donolo A, Permigiani M, Castro S: Biochemical alterations in Bradyrhizobium sp USDA 3187 induced by the fungicide Mancozeb. Antonie Van Leeuwenhoek. 1998 Apr;73(3):223-8.


In order to elucidate the fungicide toxicity mechanism we determined the effects of Mancozeb on cell chemical composition, glutathione (GSH) content (molecule involved in the detoxification process), glutathione S-transferase (GST) activity and on polyamine, exopolysaccharides, capsular polysaccharides and lipopolysaccharides.
1(0,0,0,1) Details