| Name | progesterone receptor |
|---|---|
| Synonyms | NR3C3; PGR; PR; Progesterone receptor; Progesterone receptors |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19765641 | Li J, Ma M, Wang Z: In vitro profiling of endocrine disrupting effects of phenols. Toxicol In Vitro. 2010 Feb;24(1):201-7. Epub 2009 Sep 16. In this study, the ability of 2-tert-butylphenol, 2-isopropylphenol, 4-tert-octylphenol (4-t-OP), (2,4-DCP), 3,4-dichlorophenol (3,4-DCP), pentachlorophenol (PCP), bisphenols A (BPA), tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA) and 4-phenylphenol to activate estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and -related receptor (ERR) were determined using a set of recombined yeast strains. |
31(0,1,1,1) | Details |
| 8954930 | Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, Arnold SF: Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem Biophys Res Commun. 1996 Dec 13;229(2):518-23. However, the estrogenic chemicals p-nonylphenol and 4-tert-octyphenol, and pentachlorophenol, effectively inhibited the activity of the hPR in yeast. |
2(0,0,0,2) | Details |
| 17304841 | Li J, Cui Q, Ma M, Rao KF, Wang ZJ: [Recombinant hPR gene yeast for assessing in drinking water] . Huan Jing Ke Xue. 2006 Dec;27(12):2463-6. A bioassay method using recombinant human progesterone receptor (hPR) gene yeast to evaluate the environmental endocrine disrupter effects was introduced. The result showed that the recombinant gene yeast had steroid specificity and dose-respond curve for with EC50 value of 0.5 nmol/L; The estrogenic chemicals pentachlorophenol and p-nonylphenol inhibited the activity of hPR in the yeast which had IC50 values of 2.4 micromol/L and 3.7 micromol/L, respectively. |
1(0,0,0,1) | Details |
| 16381660 | Mizota K, Ueda H: Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells. Toxicol Sci. 2006 Apr;90(2):362-8. Epub 2005 Dec 28. Some endocrine-disrupting chemicals, such as amitrol, benzophenon, bisphenol A, pentachlorophenol, and tetrabromophenol A did not cause hexosaminidase release from RBL-2H3 cells, but they blocked the release by a representative neurosteroid agonist. Having documented progesterone receptor-modulation of atrazine-induced mast cell degranulation in vitro, this response was evaluated in mice. |
1(0,0,0,1) | Details |