Protein Information

Name interleukin 2
Synonyms Aldesleukin; IL 2; IL2; Interleukin 2; Interleukin 2 precursor; T cell growth factor; TCGF; lymphokine…

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
3061993 Blecha F: Immunomodulation: a means of disease prevention in stressed livestock. J Anim Sci. 1988 Aug;66(8):2084-90.

Levamisole, thiabendazole, imuthiol, avridine, isoprinosine, bovine recombinant interferon, human recombinant interleukin-2, bovine recombinant interleukin-2 and various supplemental vitamins and minerals have been used as immunomodulators in livestock with various degrees of success.
6(0,0,1,1) Details
9345309 Calleja C, Eeckhoutte C, Larrieu G, Dupuy J, Pineau T, Galtier P: Differential effects of interleukin-1 beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes. Biochem Biophys Res Commun. 1997 Oct 9;239(1):273-8.

2(0,0,0,2) Details
2452591 Gras C, Kaplanski S, Farnarier C, Bongrand P, Chapoy P, Aubry P: [Immunological profile of Whipple's disease evolving over a period of 17 years]. Ann Med Interne. 1988;139(1):24-8.

Further, this patient suffered anguillulosis infection in 1954 and this persists despite thiabendazole therapy, as shown by periodical creeping lunear dermatitis (larva currens).
This proliferative defect seems to be due to increased PGE2 release (a 3-5 fold increase was demonstrated), resulting in inhibition of interleukin 2 (IL2) synthesis and activity.
1(0,0,0,1) Details