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thiabendazole

Identification (Source:EPA,EU)

ID	500
Name	thiabendazole
CAS	148-79-8
IUPAC
Inchi	InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
CIPAC	323
EPA Code	060101
Formula	C10H7N3S
SMILES	n2c1c(cccc1)nc2c3ncsc3
Status	Approved

Classification

Mode of Action	Systemic with curative and protective action. Acts by compromising the cytoskeleton through a selective interaction with 脽-tubulin
Pesticide Type	Fungicide
Chemical Group	Benzimidazole
Classification	benzimidazole fungicides thiazole fungicides

Properties (Source:PubChem)

Molecular Weight	201.25
Physical State	Colourless to white powder
AlogP	2.154
H-Bond Donor	1
H-Bond Acceptor	2
Surface Area	184.06
Polar Surface Area	69.81

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	3.2 mg l-1
Algae	Acute	72 hour	EC50, growth	9.0 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.34 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.81 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.042 mg l-1
Birds	Acute		LD50	> 2250 mg kg-1
Birds	Short term dietary		LC50/LD50	> 5620 mg/kg feed
Earthworms	Acute	14 day	LD50	> 1000 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	4.2 mg kg-1
Fish	Acute	96 hour	LC50	0.55 mg l-1
Fish	Chronic	21 day	NOEC	0.012 mg l-1
Honeybees	Acute	48 hour	LD50	50 μg bee-1
Mammals	Acute oral		LD50	3100 mg kg-1
Mammals	Short term dietary		NOEL	> 10 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	2.0 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	3.0 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	96.5

Related targets

Target Name	RScore (About this table)
CYP1A2	801(8,12,12,41)	Details
cytochrome P450 (protein family or complex)	330(3,5,7,20)	Details
cytochrome P450 1A1	282(2,4,9,37)	Details
carbonic anhydrase	195(2,3,3,5)	Details
aryl hydrocarbon receptor	148(1,3,3,8)	Details
superoxide dismutase	97(1,1,2,12)	Details
alpha tubulin	95(1,1,2,10)	Details
glutathione S transferase	85(1,1,1,5)	Details
methionine aminopeptidase	83(1,1,1,3)	Details
THBD	82(1,1,1,2)	Details
c fos	81(1,1,1,1)	Details
carbonic anhydrases (protein family or complex)	81(1,1,1,1)	Details
succinate dehydrogenase (protein family or complex)	71(0,2,3,6)	Details
IgE	83(0,1,4,38)	Details
gamma tubulin complex (protein family or complex)	55(0,1,2,20)	Details
cyclin	41(0,1,2,6)	Details
GF1	37(0,1,2,2)	Details
Acetylcholinesterase	37(0,1,1,7)	Details
malate dehydrogenase	36(0,1,1,6)	Details
TRF4	36(0,1,1,6)	Details
NPS1	35(0,1,1,5)	Details
Microsomal monooxygenase	33(0,1,1,3)	Details
CS2	33(0,1,1,3)	Details
CAPS	32(0,1,1,2)	Details
proton pump	32(0,1,1,2)	Details
GADD153	31(0,1,1,1)	Details
GRP78	31(0,1,1,1)	Details
acetylcholine receptors (protein family or complex)	31(0,1,1,1)	Details
thromboxane synthase	31(0,1,1,1)	Details
PF4	26(0,0,4,6)	Details
C18	23(0,0,2,13)	Details
arrestin	17(0,0,1,12)	Details
transducin	15(0,0,1,10)	Details
MSRB	15(0,0,2,5)	Details
P glycoproteins	14(0,0,0,14)	Details
interferon (protein family or complex)	13(0,0,2,3)	Details
CBF1	11(0,0,1,6)	Details
complex is	10(0,0,1,5)	Details
Dicer	10(0,0,1,5)	Details
interleukin 2	9(0,0,1,4)	Details
kinesin	9(0,0,0,9)	Details

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