| Name | aryl hydrocarbon receptor |
|---|---|
| Synonyms | AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs… |
| Name | thiabendazole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14987951 | Lemaire G, Delescluse C, Pralavorio M, Ledirac N, Lesca P, Rahmani R: The role of protein tyrosine kinases in CYP1A1 induction by and thiabendazole in rat hepatocytes. Life Sci. 2004 Mar 19;74(18):2265-78. Benzimidazoles compounds like (OME) and thiabendazole (TBZ) mediate CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-methylcholanthrene (3-MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). |
83(1,1,1,3) | Details |
| 10445394 | Kikuchi H, Hossain A: Signal transduction-mediated CYP1A1 induction by in human HepG2 cells. Exp Toxicol Pathol. 1999 Jul;51(4-5):342-6. Benzimidazole compounds, such as and thiabendazole, are a different type of CYP1A1-inducer from Ah receptor-ligands, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. |
31(0,1,1,1) | Details |
| 9784250 | Kikuchi H, Hossain A, Yoshida H, Kobayashi S: Induction of cytochrome P-450 1A1 by in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone. Arch Biochem Biophys. 1998 Oct 15;358(2):351-8. Benzimidazole compounds, such as and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene. |
31(0,1,1,1) | Details |
| 19754423 | Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. In particular, several therapeutic drugs including antofloxacin, carbamazepine, dihydralazine, furafylline, isoniazid, rofecoxib, clorgyline, thiabendazole, and zileuton are mechanism-based inhibitors of CYP1A2. Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors. |
1(0,0,0,1) | Details |
| 10103034 | Backlund M, Weidolf L, Ingelman-Sundberg M: Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. Eur J Biochem. 1999 Apr;261(1):66-71. thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. Thus, these data indicate that the benzimidazoles utilize the aryl hydrocarbon receptor-arnt-XRE-mediated signal-transduction pathway for induction of the CYP1A1 gene. |
1(0,0,0,1) | Details |
| 10563046 | Hoogenboom LA, Hamers AR, Bovee TF: Bioassays for the detection of growth-promoting agents, veterinary drugs and environmental contaminants in food. Analyst. 1999 Jan;124(1):79-85. The CALUX (chemical activated luciferase expression) assay was developed for the detection of polyhalogenated compounds, based on their affinity for the aryl hydrocarbon (Ah) receptor. The benzimidazole compounds oxfendazole, fenbendazole, febantel, thiabendazole, mebendazole, lanzoprazole and benomyl were shown to give a positive response in the assay. |
1(0,0,0,1) | Details |
| 8900397 | Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J, Watanabe M: Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction. Arch Biochem Biophys. 1996 Oct 15;334(2):235-40. Three benzimidazole compounds, (OP), thiabendazole (TBZ), and (LP), were compared with respect to the induction of CYP1A1-mRNA in human hepatoma cells, HepG2. |
0(0,0,0,0) | Details |
| 7520238 | Aix L, Rey-Grobellet X, Larrieu G, Lesca P, Galtier P: Thiabendazole is an inducer of cytochrome P4501A1 in cultured rabbit hepatocytes. Biochem Biophys Res Commun. 1994 Aug 15;202(3):1483-9. |
0(0,0,0,0) | Details |
| 11226373 | Delescluse C, Ledirac N, Li R, Piechocki MP, Hines RN, Gidrol X, Rahmani R: Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem Pharmacol. 2001 Feb 15;61(4):399-407. |
0(0,0,0,0) | Details |