| Name | cytochrome P450 1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | thiabendazole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14987951 | Lemaire G, Delescluse C, Pralavorio M, Ledirac N, Lesca P, Rahmani R: The role of protein tyrosine kinases in CYP1A1 induction by and thiabendazole in rat hepatocytes. Life Sci. 2004 Mar 19;74(18):2265-78. Benzimidazoles compounds like (OME) and thiabendazole (TBZ) mediate CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-methylcholanthrene (3-MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). |
93(1,1,2,8) | Details |
| 8607843 | Rey-Grobellet X, Ferre N, Eeckhoutte C, Larrieu G, Pineau T, Galtier P: Structural requirements for the induction of cytochromes P450 by benzimidazole anthelmintic derivatives in cultured rabbit hepatocytes. Biochem Biophys Res Commun. 1996 Mar 27;220(3):789-94. The effect of -containing benzimidazoles (thiabendazole, 5--thiabendazole, cambendazole) and -free derivatives (benzimidazole, carbendazim and 5-hydroxycarbendazim) on cytochrome P450 enzymes was investigated in primary cultures of rabbit hepatocytes considered 72 h after plating. Experiments using actinomycin D strongly suggest that these compounds have a transcriptional control on both CYP1A1 and CYP1A2 genes in primary hepatocytes. |
1(0,0,0,1) | Details |
| 11226373 | Delescluse C, Ledirac N, Li R, Piechocki MP, Hines RN, Gidrol X, Rahmani R: Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem Pharmacol. 2001 Feb 15;61(4):399-407. Carbaryl and thiabendazole were found to activate CYP1A1 at the level of transcription, as demonstrated by the dose-dependent increase in reporter CAT and CYP1A1 mRNAs. |
89(1,1,2,4) | Details |
| 9784250 | Kikuchi H, Hossain A, Yoshida H, Kobayashi S: Induction of cytochrome P-450 1A1 by in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone. Arch Biochem Biophys. 1998 Oct 15;358(2):351-8. Benzimidazole compounds, such as and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene. |
35(0,1,1,5) | Details |
| 10445394 | Kikuchi H, Hossain A: Signal transduction-mediated CYP1A1 induction by in human HepG2 cells. Exp Toxicol Pathol. 1999 Jul;51(4-5):342-6. Benzimidazole compounds, such as and thiabendazole, are a different type of CYP1A1-inducer from Ah receptor-ligands, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. |
34(0,1,1,4) | Details |
| 10103034 | Backlund M, Weidolf L, Ingelman-Sundberg M: Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. Eur J Biochem. 1999 Apr;261(1):66-71. thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. |
16(0,0,2,6) | Details |
| 8900397 | Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J, Watanabe M: Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction. Arch Biochem Biophys. 1996 Oct 15;334(2):235-40. Three benzimidazole compounds, (OP), thiabendazole (TBZ), and (LP), were compared with respect to the induction of CYP1A1-mRNA in human hepatoma cells, HepG2. |
9(0,0,1,4) | Details |
| 9345309 | Calleja C, Eeckhoutte C, Larrieu G, Dupuy J, Pineau T, Galtier P: Differential effects of interleukin-1 beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes. Biochem Biophys Res Commun. 1997 Oct 9;239(1):273-8. However specific patterns of action are revealed: IL-1 beta is the most potent cytokine in regard to CYP1A1/2 mRNA suppression whereas IL-2 exerts repressive effects only on P4501A1 induced expression. |
2(0,0,0,2) | Details |
| 15110098 | Price RJ, Scott MP, Walters DG, Stierum RH, Groten JP, Meredith C, Lake BG: Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes. Food Chem Toxicol. 2004 Jun;42(6):899-908. The administration of high doses of TB resulted in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. |
1(0,0,0,1) | Details |
| 8819304 | Rey-Grobellet X, Eeckhoutte C, Sutra JF, Alvinerie M, Galtier P: Major involvement of rabbit liver cytochrome P4501A in thiabendazole 5-hydroxylation. Xenobiotica. 1996 Jul;26(7):765-78. These treatments led to specific induction of CYP1A1, 1A2, 2B4, 3A6 and 4A1 respectively. 3. |
1(0,0,0,1) | Details |
| 19754423 | Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. In particular, several therapeutic drugs including antofloxacin, carbamazepine, dihydralazine, furafylline, isoniazid, rofecoxib, clorgyline, thiabendazole, and zileuton are mechanism-based inhibitors of CYP1A2. Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors. |
1(0,0,0,1) | Details |
| 10936227 | Coulet M, Eeckhoutte C, Larrieu G, Sutra JF, Alvinerie M, Mace K, Pfeifer A, Zucco F, Stammati AL, De Angelis I, Vignoli AL, Galtier P: Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells. Chem Biol Interact. 2000 Jul 3;127(2):109-24. |
0(0,0,0,0) | Details |