Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
7797368 Mallet S, Hoste H: Physiology of two strains of Trichostrongylus colubriformis resistant and susceptible to thiabendazole and mucosal response of experimentally infected rabbits. Int J Parasitol. 1995 Jan;25(1):23-7.

The physiology of the worms was characterised by in vitro acetylcholinesterase secretion of adult worms.
1(0,0,0,1) Details
3840531 Sangster NC, Prichard RK, Lacey E: Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (Nematoda). J Parasitol. 1985 Oct;71(5):645-51.


Benzimidazole treatment produced greater effects on microtubule-dependent acetylcholinesterase secretion, the presence of microtubules in intestinal cells, and colchicine binding in susceptible compared with benzimidazole-resistant Trichostrongylus colubriformis.
1(0,0,0,1) Details
2314926 Sutherland IA, Lee DL: A larval paralysis assay for the detection of thiabendazole resistance in trichostrongyles. Parasitology. 1990 Feb;100 Pt 1:131-5.

Infective-stage larvae of trichostrongyle nematodes, either resistant or susceptible to thiabendazole (TBZ), were incubated in eserine, an acetylcholinesterase inhibitor.
32(0,1,1,2) Details
7150334 Watts SD, Rapson EB, Atkins AM, Lee DL: Inhibition of acetylcholinesterase secretion from Nippostrongylus brasiliensis by benzimidazole anthelmintics. Biochem Pharmacol. 1982 Oct 1;31(19):3035-40.

When parasites were incubated in vitro with 0.1 mM oxfendazole, mebendazole, flubendazole, parbendazole, cambendazole or thiabendazole a similar effect was observed; with oxfendazole and mebendazole the effect was apparent within 1 hr and lasted for at least 4 hr after removal to fresh, drug-free medium.
3(0,0,0,3) Details