| 3840531 |
Sangster NC, Prichard RK, Lacey E: Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (Nematoda). J Parasitol. 1985 Oct;71(5):645-51.
Benzimidazole treatment produced greater effects on microtubule-dependent acetylcholinesterase secretion, the presence of microtubules in intestinal cells, and colchicine binding in susceptible compared with benzimidazole-resistant Trichostrongylus colubriformis. In addition, the binding of benzimidazoles was markedly reduced in preparations from the latter strain, indicating that the mechanism of resistance to benzimidazoles in this nematode involves a reduced affinity of tubulin for benzimidazoles. |
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