| Name | P glycoproteins |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | thiabendazole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18241994 | Blackhall WJ, Prichard RK, Beech RN: P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet Parasitol. 2008 Mar 25;152(1-2):101-7. Epub 2007 Dec 8. The same allele was also found at a high frequency in an independently derived thiabendazole-selected field isolate. |
6(0,0,0,6) | Details |
| 12172813 | Kerboeuf D, Guegnard F, Le Vern Y: Analysis and partial reversal of multidrug resistance to anthelmintics due to P-glycoprotein in Haemonchus contortus eggs using Lens culinaris lectin. Parasitol Res. 2002 Sep;88(9):816-21. Epub 2002 May 16. Highly significant reversion (up to 50%) in the resistance to thiabendazole of eggs pre-treated with the lectin was obtained. |
3(0,0,0,3) | Details |
| 12865394 | Riou M, Guegnard F, Le Vern Y, Kerboeuf D: Modulation of the multidrug resistance (MDR) system in the nematode Haemonchus contortus by changing content: effects on resistance to anthelmintics. J Antimicrob Chemother. 2003 Aug;52(2):180-7. Epub 2003 Jul 15. The resulting changes in resistance were estimated by measuring changes in drug transport (a) by means of in vitro egg hatch assays in the presence of a benzimidazole anthelmintic, thiabendazole and (b) by measuring the transport of rhodamine 123 (R123), a specific substrate of Pgp. Membrane 'pumps', known as P-glycoproteins (Pgp), are activated in the MDR system. |
2(0,0,0,2) | Details |
| 9934960 | Kerboeuf D, Chambrier P, Le Vern Y, Aycardi J: Flow cytometry analysis of drug transport mechanisms in Haemonchus contortus susceptible or resistant to anthelmintics. Parasitol Res. 1999 Feb;85(2):118-23. Rhodamine 123, a P-glycoprotein transport probe, associated with the reversal agent gave a significantly higher level of green fluorescence in Haemonchus contortus-resistant eggs as compared with that of susceptible eggs. |
1(0,0,0,1) | Details |
| 16846720 | Hayeshi R, Masimirembwa C, Mukanganyama S, Ungell AL: The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. Eur J Pharm Sci. 2006 Sep;29(1):70-81. Epub 2006 Jun 3. Quinine, amodiaquine, chloroquine, praziquantel, and thiabendazole were further investigated in bidirectional transport assays to determine whether they were substrates for Pgp. |
2(0,0,0,2) | Details |