Protein Information

Name kinesin
Synonyms KIF5C; KIF5A; NKHC; KINN; Kinesin family member 5C; Kinesin heavy chain isoform 5C; Kinesin heavy chain neuron specific 2; NKHC 2…

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
10641037 Brazer SC, Williams HP, Chappell TG, Cande WZ: A fission yeast kinesin affects Golgi membrane recycling. Yeast. 2000 Jan 30;16(2):149-66.

Neither latrunculin A nor thiabendazole affects ER or Golgi distribution.
2(0,0,0,2) Details
16079915 Sanchez-Perez I, Renwick SJ, Crawley K, Karig I, Buck V, Meadows JC, Franco-Sanchez A, Fleig U, Toda T, Millar JB: The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. EMBO J. 2005 Aug 17;24(16):2931-43. Epub 2005 Aug 4.

We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cyclin B) and mal3-1 (EB-1) cells to thiabendazole, a microtubule poison.
2(0,0,0,2) Details
15766794 Korolyev E, Steinberg-Neifach O, Eshel D: Mutations in the yeast kinesin-like Cin8p are alleviated by osmotic support. FEMS Microbiol Lett. 2005 Mar 15;244(2):379-83.

2(0,0,0,2) Details
15280226 Tange Y, Fujita A, Toda T, Niwa O: Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe. Genetics. 2004 Jul;167(3):1095-107.

In addition, genetic data indicated intimate functional connections of gamma-tubulin with several kinesin-like proteins.
The cold sensitivity of gamma-tubulin mutants was almost completely suppressed by an alpha-tubulin mutation and partially suppressed by a low concentration of thiabendazole, a microtubule assembly inhibitor.
1(0,0,0,1) Details
11694582 Troxell CL, Sweezy MA, West RR, Reed KD, Carson BD, Pidoux AL, Cande WZ, McIntosh JR: pkl1 (+) and klp2 (+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis. Mol Biol Cell. 2001 Nov;12(11):3476-88.


We have identified Klp2p, a new kinesin-like protein (KLP) of the KAR3 subfamily in fission yeast.
1(0,0,0,1) Details
11739790 West RR, Malmstrom T, Troxell CL, McIntosh JR: Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast. Mol Biol Cell. 2001 Dec;12(12):3919-32.

The kinesin superfamily of microtubule motor proteins is important in many cellular processes, including mitosis and meiosis, vesicle transport, and the establishment and maintenance of cell polarity.
Analysis of null mutants demonstrates that neither klp5+ nor klp6+, individually or together, is essential for vegetative growth, although these mutants have altered microtubule behavior. klp5Delta and klp6Delta are resistant to high concentrations of the microtubule poison thiabendazole and have abnormally long cytoplasmic microtubules that can curl around the ends of the cell.
1(0,0,0,1) Details