Protein Information

Name calcitonin gene related peptide
Synonyms Alpha type CGRP; CT; CGRP; CALC 1; CALC1; CALCA; CGRP 1; CGRP I…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
1319450 Leung AY, Leung PY, Cheng-Chew SB, Wong PY: The role of calcitonin gene-related peptide in the regulation of anion secretion by the rat and human epididymis. J Endocrinol. 1992 May;133(2):259-68.

The current could be inhibited by apical application of the chloride channel blocker, diphenylamine-2-carboxylate.
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8661992 Tauc M, Bidet M, Poujeol P: Chloride currents activated by calcitonin and cAMP in primary cultures of rabbit distal convoluted tubule. J Membr Biol. 1996 Apr;150(3):255-73.

This current was inhibited by 10 (-3) M diphenylamine-2-carboxylate (DPC) and 10 (-4) M 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB) and was insensitive to 10 (-3) M 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).
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8447435 Siga E, Mandon B, Roinel N, de Rouffignac C: Effects of calcitonin on function of intercalated cells of rat cortical collecting duct. Am J Physiol. 1993 Feb;264(2 Pt 2):F221-7.

The CT-induced lumen-positive PDte was reduced by 2.3 +/- 0.8 mV after the basolateral addition of the Cl- channel inhibitor diphenylamine-2-carboxylate. 4-Acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid and acetazolamide, which inhibit Cl-/HCO3- exchangers and carbonic anhydrase activities, respectively, also inhibited the CT-induced PDte by 4.6 +/- 0.5 and 5.0 +/- 0.9 mV.
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1684913 Merot J, Poncet V, Bidet M, Tauc M, Poujeol P: Apical membrane ionic channels in the rabbit cortical thick ascending limb in primary culture. Biochim Biophys Acta. 1991 Dec 9;1070(2):387-400.

Cyclic AMP production of the cultured cells was increased by human calcitonin (x13) and parathyroid hormone (x2).
The basolateral membrane of the cells exhibited a chloride conductance sensitive to diphenylamine 2-carboxylate (DPC) and the apical membrane a barium-sensitive K+ permeability.
1(0,0,0,1) Details