Protein Information

Name PACAP
Synonyms Caspase 2 binding protein; PACAP; HSPC190; PACAP protein; Proapoptotic caspase adaptor protein; PACAP proteins; Proapoptotic caspase adaptor proteins

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
11237416 Leung PS, So SC, Lam SY, Tsang LL, Chung YW, Chan HC: Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells. Cell Biol Int. 2001;25(2):123-9.

The I (SC) responses to both PACAP-27 and PACAP-38 were suppressed respectively by the non-selective Cl (-) channel blocker, diphenylamine-dicarboxylic acid (DPC), by the Ca (2+) dependent Cl (-) channel blocker, diisothiocyanatostilbene-disulfonic acid (DIDS) and by the Ca (2+) chelator, BAPTA-AM, indicating the involvement of Ca (2+).
89(1,1,1,9) Details
9379115 Zhou WL, Leung PS, Wong TP, Dun NJ, Wong PY, Chan HC: Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide. J Endocrinol. 1997 Sep;154(3):389-95.

The present study investigated the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of electrogenic anion secretion by the rat cauda epididymal epithelium.
The Isc response to PACAP38 was abolished in Cl-(-) free solution and completely inhibited by the Cl- channel blocker, diphenylamine-dicarboxylic acid.
1(0,0,0,1) Details