| Name | bcl 2 |
|---|---|
| Synonyms | Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas… |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9695733 | Knowlton K, Mancini M, Creason S, Morales C, Hockenbery D, Anderson BO: Bcl-2 slows in vitro breast cancer growth despite its antiapoptotic effect. J Surg Res. 1998 Apr;76(1):22-6. Cells were treated for 72 h with doxorubicin (100 ng/ml) or vehicle (0.01% DMSO) and assayed for cytosolic DNA with diphenylamine to measure apoptosis. |
8(0,0,0,8) | Details |
| 15301745 | Zheng XL, Sun HX, Liu XL, Chen YX, Qian BC: Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3. Acta Pharmacol Sin. 2004 Aug;25(8):1090-5. Content of DNA in COLO 205 cell was measured by modified diphenylamine assay. |
4(0,0,0,4) | Details |
| 15538571 | Zhang XM, Chen J, Xia YG, Xu Q: Apoptosis of murine melanoma B16-BL6 cells induced by targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta. Cancer Chemother Pharmacol. 2005 Mar;55(3):251-62. Epub 2004 Nov 5. DNA fragmentation was analyzed by electrophoresis and quantified by the diphenylamine method. Bcl-2, Bcl-X (L), PKC-alpha, PKC-beta, and PKC-delta were detected by Western blotting. |
4(0,0,0,4) | Details |
| 9593266 | Robertson KA, Hill DP, Kelley MR, Tritt R, Crum B, Van Epps S, Srour E, Rice S, Hromas R: The myeloid zinc finger gene (MZF-1) delays -induced apoptosis and differentiation in myeloid leukemia cells. Leukemia. 1998 May;12(5):690-8. Expression of the bcl-2 proto-oncogene transcript and protein was higher in the HL-60-MZF-1 cells compared to wild-type HL-60s and expression persisted for 5 days following RA in the HL-60-MZF-1 cells compared to only 3 days in the parental HL-60 cells suggesting that bcl-2 may contribute to the inhibition of apoptosis. Apoptosis was delayed in the MZF-1 transduced cells as measured by internucleosomal DNA fragmentation patterns, the terminal transferase end labeling reaction (TUNEL), and quantitation of fragmented DNA by the diphenylamine reaction. |
1(0,0,0,1) | Details |
| 19649202 | Ciuffreda L, Del Bufalo D, Desideri M, Di Sanza C, Stoppacciaro A, Ricciardi MR, Chiaretti S, Tavolaro S, Benassi B, Bellacosa A, Foa R, Tafuri A, Cognetti F, Anichini A, Zupi G, Milella M: Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations. Neoplasia. 2009 Aug;11(8):720-31. Cell cycle (cyclin D1, c-Myc, and p27 (KIP1)) and apoptosis (Bcl-2 and survivin) regulators were modulated by PD0325901 at the protein level. |
1(0,0,0,1) | Details |
| 19705349 | Abid-Essefi S, Bouaziz C, Golli-Bennour EE, Ouanes Z, Bacha H: Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells. J Biochem Mol Toxicol. 2009 Jul;23(4):233-43. To check whether the oxidative stress induction was associated to DNA lesions, we looked for DNA fragmentation by means of the Comet and the diphenylamine assays. To specify cell death pathway, we investigated caspase-3 activation, confirmed by poly (ADP- polymerase cleavage and by Bcl-2 depletion. |
1(0,0,0,1) | Details |
| 9607633 | Mancini M, Sedghinasab M, Knowlton K, Tam A, Hockenbery D, Anderson BO: Flow cytometric measurement of mitochondrial mass and function: a novel method for assessing chemoresistance. Ann Surg Oncol. 1998 Apr-May;5(3):287-95. We hypothesize that (1) chemotherapeutic agents induce mitochondrial changes and apoptosis through mechanisms associated with reactive oxidant species production; (2) the anti-apoptotic protein Bcl-2 prevents drug-induced mitochondrial changes, reactive species (ROS) production, and apoptosis; and (3) the assay of drug-induced mitochondrial changes can reflect drug-specific chemoresistance in a given cancer cell line. Apoptosis was determined by electron microscopy, TUNEL (TdT-mediated - nick end labeling) staining, and diphenylamine assay of DNA fragmentation. |
2(0,0,0,2) | Details |
| 9888876 | Suenobu N, Shichiri M, Iwashina M, Marumo F, Hirata Y: Natriuretic peptides and induce endothelial apoptosis via a -dependent mechanism. Arterioscler Thromb Vasc Biol. 1999 Jan;19(1):140-6. This dose-dependent relation was assessed by quantifying the fragmented and intact DNA contents by the diphenylamine method. |
0(0,0,0,0) | Details |