| 11045459 |
Ohta K, Kawachi E, Inoue N, Fukasawa H, Hashimoto Y, Itai A, Kagechika H: Retinoidal pyrimidinecarboxylic acids. Chem Pharm Bull. 2000 Oct;48(10):1504-13.
On the other hand, pyrimidine analogs (PA series, 10 and 11) of potent RXR agonists (retinoid synergists) with a diphenylamine skeleton (DA series, 8 and 9) exhibited potent retinoid synergistic activity in HL-60 cell differentiation assay and activated RXRs. |
82(1,1,1,2) |
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| 18760603 |
Ohta K, Chiba Y, Ogawa T, Endo Y: Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5050-3. Epub 2008 Aug 6.
We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. |
81(1,1,1,1) |
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