| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20045694 | Almeida-Amaral EE, Cardoso VC, Francioli FG, Meyer-Fernandes JR: Leishmania amazonensis: heme stimulates (Na (+)+K (+)) ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways. Exp Parasitol. 2010 Apr;124(4):436-41. Epub 2010 Jan 4. |
1(0,0,0,1) | Details |
| 15194239 | Piacentini MP, Piatti E, Fraternale D, Ricci D, Albertini MC, Accorsi A: Phospholipase C-dependent phosphoinositide breakdown induced by ELF-EMF in Peganum harmala calli. Biochimie. 2004 Apr-May;86(4-5):343-9. The manipulation of the lipid-based signalling pathway by phosphoinositide-phospholipase C (PI-PLC) inhibitors (i.e., neomycin, U-73122 and ET-18-OCH (3)) seems to support the hypothesis that, as in animals, also in plants, the cell membrane is the primary impact site of ELF electromagnetic stimulus and that this interaction could probably involve the activation of PI signal transduction pathway including a heterotrimeric G protein. |
1(0,0,0,1) | Details |
| 19961846 | Nakamura K, Yokotani K: Presynaptic BK type Ca (2+)-activated K (+) channels are involved in prostanoid TP receptor-mediated inhibition of release from the rat gastric sympathetic nerves. Eur J Pharmacol. 2010 Mar 10;629(1-3):111-7. Epub 2009 Dec 2. Prostanoid TP receptor has been shown to activate phospholipase C (PLC), which catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5- (IP (3)) and diacylglycerol; IP (3) triggers the release of Ca (2+) from intracellular stores and diacylglycerol activates protein kinase C. |
1(0,0,0,1) | Details |
| 10860858 | Kane JK, Tanaka H, Parker SL, Yanagisawa M, Li MD: Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin. Biochem Biophys Res Commun. 2000 Jun 16;272(3):959-65. |
1(0,0,0,1) | Details |
| 12384249 | Easton AS, Abbott NJ: Bradykinin increases permeability by and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. Brain Res. 2002 Oct 25;953(1-2):157-69. The putative phospholipase C inhibitors, U73122 (20 microM) and ETH-18-OCH (3) (100 microM), unexpectedly increased [Ca (2+)](i); after their application, bradykinin was ineffective. |
1(0,0,0,1) | Details |
| 18804531 | Eisinger DA, Ammer H: Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases. Cell Signal. 2008 Dec;20(12):2324-31. Epub 2008 Sep 5. Further studies with the phospholipase C (PLC) inhibitors U73122 and ET-18-OCH (3) revealed that opioid-stimulated integrin activation is sensitive to PLC. |
1(0,0,0,1) | Details |
| 18072286 | Weng JY, Hsu TT, Sun SH: Functional characterization of P2Y1 versus P2X receptors in RBA-2 astrocytes: elucidate the roles of ATP release and protein kinase C. J Cell Biochem. 2008 May 15;104(2):554-67. The 2MeSADP-mediated biphasic Ca (2+) signals were inhibited by phospholipase C (PLC) inhibitor U73122, and completely blocked by P2Y (1) selective antagonist MRS2179 and protein kinase C (PKC) activator phorbol 12- 13- (PMA) whereas enhanced by PKC inhibitors GF109203X and Go6979. |
1(0,0,0,1) | Details |
| 16522737 | Orihuela PA, Parada-Bustamante A, Zuniga LM, Croxatto HB: Inositol triphosphate participates in an nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats. J Endocrinol. 2006 Mar;188(3):579-88. Oestrous rats were injected with E (2) s.c. and intrabursally (i.b) with the selective inhibitors of phospholipase C (PLC) ET-18-OCH (3) or MAPK PD98059. |
1(0,0,0,1) | Details |
| 11931646 | Crljen V, Volinia S, Banfic H: Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Biochem J. 2002 Aug 1;365(Pt 3):791-9. Whereas in BLM rapid increases in 1,2-diacylglycerol, PtdIns (3,4,5) P (3) and PtdIns (3,4) P (2) were observed, suggesting that in BLM HGF activates both phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K), in BBM only HGF-induced transient accumulation of PtdIns3P was seen, which was temporarily delayed from signalling events in BLM and could be blocked by the PtdIns-specific-PLC inhibitor ET-18-OCH (3) and the calpain inhibitor calpeptin, suggesting that 3-kinase activation in BBM lies downstream of PLC activation in BLM and is a calpain-mediated event. |
1(0,0,0,1) | Details |
| 15929741 | Sawisky GR, Chang JP: Intracellular involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells. J Neuroendocrinol. 2005 Jun;17(6):353-71. The phosphatidyl inositol (PI)-specific phospholipase C (PLC) inhibitor ET-18-OCH (3) inhibited, whereas the phosphatidyl- (PC)-specific PLC inhibitor D609 enhanced, PACAP-stimulated GH and GTH-II responses. |
1(0,0,0,1) | Details |
| 10938438 | Narita M, Ohsawa M, Mizoguchi H, Aoki T, Suzuki T, Tseng LF: Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord. Neuroscience. 2000;99(2):327-31. |
5(0,0,0,5) | Details |
| 10688599 | Llansola M, Monfort P, Felipo V: Inhibitors of phospholipase C prevent neurotoxicity in primary cultures of cerebellar neurons. J Pharmacol Exp Ther. 2000 Mar;292(3):870-6. |
5(0,0,0,5) | Details |
| 12140177 | Wang CT, Loch-Caruso R: Phospholipase-mediated inhibition of spontaneous oscillatory uterine contractions by lindane in vitro. Toxicol Appl Pharmacol. 2002 Jul 15;182(2):136-47. Pretreatment with 20-50 microM of the phosphatidylinositol-specific phospholipase C inhibitor 1-O-octadecyl-2-O-methyl-sn--3- (ET-18-OCH (3)) reversed lindane-induced inhibition of spontaneous uterine contractions. |
3(0,0,0,3) | Details |
| 12065624 | Donald AN, Wallace DJ, McKenzie S, Marley PD: Phospholipase C-mediated signalling is not required for -induced catecholamine secretion from bovine chromaffin cells. J Neurochem. 2002 Jun;81(5):1116-29. A possible role for signalling through phospholipase C in -induced catecholamine secretion from bovine chromaffin cells has been investigated. |
3(0,0,0,3) | Details |
| 10834929 | Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG: Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun;14(9):1083-92. |
2(0,0,0,2) | Details |
| 17363325 | Lukinovic-Skudar V, Matkovic K, Banfic H, Visnjic D: Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G (1) phase of the cell cycle. Biochim Biophys Acta. 2007 Apr;1771(4):514-21. Epub 2007 Feb 13. |
2(0,0,0,2) | Details |
| 18191462 | Schmolke M, Fabian J, Lehr M: High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C. Anal Biochem. 2008 Apr 15;375(2):291-8. Epub 2007 Dec 25. |
2(0,0,0,2) | Details |
| 17596535 | Frazier EP, Braverman AS, Peters SL, Michel MC, Ruggieri MR Sr: Does phospholipase C mediate muscarinic receptor-induced rat urinary bladder contraction?. J Pharmacol Exp Ther. 2007 Sep;322(3):998-1002. Epub 2007 Jun 27. |
2(0,0,0,2) | Details |
| 12972400 | Son M, Ito Y, Sato S, Ishikawa T, Kondo M, Nakayama S, Shimokata K, Kume H: Apical and basolateral ATP-induced anion secretion in polarized human airway epithelia. Am J Respir Cell Mol Biol. 2004 Mar;30(3):411-9. Epub 2003 Sep 11. Antagonists of phosphatidylinositol-phospholipase C (U73122, ET-18-OCH (3)) were without any effect on the bilateral ATP-induced I (sc), which were, in contrast, attenuated by a -phospholipase C inhibitor (D609) and an adenylate cyclase inhibitor (SQ22536). |
2(0,0,0,2) | Details |
| 16243961 | Braverman AS, Tibb AS, Ruggieri MR Sr: M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. J Pharmacol Exp Ther. 2006 Feb;316(2):869-74. Epub 2005 Oct 21. Inhibition of phosphoinositide-specific phospholipase C (PI-PLC) with 1-O-octadecyl-2-O-methyl-sn-glycero-3- (ET-18-OCH (3)) reduces carbachol potency and reduces darifenacin affinity, whereas inhibition of phosphatidyl -specific phospholipase C (PC-PLC) with O-tricyclo [5.2.1.02,6] dec-9-yl dithiocarbonate salt (D609) attenuates the carbachol maximal contraction. |
1(0,0,0,1) | Details |
| 11557588 | Sano A, Zhu X, Sano H, Munoz NM, Boetticher E, Leff AR: Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA (2). Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L844-51. We examined the regulatory role of cytosolic phospholipase A (2) (cPLA (2)) and phosphatidylinositol (PI)-specific phospholipase C (PLC) in the degranulation of human eosinophils and leukotriene (LT) C (4) synthesis. |
1(0,0,0,1) | Details |