Protein Information

Name COCH
Synonyms COCH; COCH 5B2; COCH5B2; Cochlin; Cochlin precursor; DFNA 9; DFNA31; DFNA9…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
19584101 Pazynina G, Sablina M, Mayzel M, Nasonov V, Tuzikov A, Bovin N: Chemical synthesis of 6 (GlcNAc)- and 6 (Gal)-O-sulfated SiaLe (X) tetrasaccharides in spacer-armed form. Glycobiology. 2009 Oct;19(10):1078-81. Epub 2009 Jul 7.

The sulfated SiaLe (x) derivative was modified at the spacer group to give 6 ((Gal))-O-Su-SiaLe (x)- OCH (2) CH (2) CH (2) NH-COCH (2) CH (2) C [triple bond] CH, convenient for "click chemistry" mode conjugation with an azido carrier, particularly, for the synthesis of an immunogen.
31(0,1,1,1) Details
15154812 Wei QH, Yin GQ, Zhang LY, Shi LX, Mao ZW, Chen ZN: Luminescent Ag i-Cu i heterometallic hexa-, octa-, and hexadecanuclear alkynyl complexes. Inorg Chem. 2004 May 31;43(11):3484-91.


Self-assembly reaction between (MCCC (6) H (4) COCH (3)-4)(n) and [M'(2)(mu-Ph (2) PCH (2) PPh (2))(2)(MeCN)(2)](ClO (4))(2), however, gave heterohexadecanuclear complex [Ag (6) Cu (2)(micro-Ph (2) PCH (2) PPh (2))(3)(CCC (6) H (4) COCH (3)-4)(6)](2)(ClO (4) )(4) (7).
2(0,0,0,2) Details
11559172 Singh RP, Majumder U, Shreeve JM: Nucleophilic di- and tetrafluorination of dicarbonyl compounds. J Org Chem. 2001 Sep 21;66(19):6263-7.


Reactions of beta-diketones, R (3) COCH (2) COR (4) (R (3) = R (4) = Ph; R (3) = R (4) = Me; R (3) = Me, R (4) = Ph) (4e-g), with Deoxofluor in the presence of a catalytic amount of HF led to the formation of difluoroalkenones as a mixture of E (5e-g) and Z (6e-g) isomers in good yield.
1(0,0,0,1) Details
17589872 Yamnitz CR, Gokel GW: Synthetic, biologically active amphiphilic peptides. Chem Biodivers. 2007 Jun;4(6):1395-412.


The main focus of this article lies on the family of synthetic anion binders (SATs) of the general structure (R (1))(2) N-COCH (2) OCH (2) CO-(Aaa)(n)-OR (3).
2(0,0,0,2) Details
18688484 You L, Li R, Gokel GW: Anion transport properties of amine and amide-sidechained peptides are affected by charge and phospholipid composition. Org Biomol Chem. 2008 Aug 21;6(16):2914-23. Epub 2008 Jun 16.


Four synthetic anion transporters (SATs) having the general formula (n-C (18) H (37))(2) N-COCH (2) OCH (2) CO-(Gly)(3) Pro-Lys (epsilon-N-R)-(Gly)(2)-O -n-C (7) H (15) were prepared and studied.
1(0,0,0,1) Details
12919040 Rayabarapu DK, Yang CH, Cheng CH: Regioselective synthesis of indenols via nickel-catalyzed carbocyclization reaction. J Org Chem. 2003 Aug 22;68(17):6726-31.


2-Halophenyl ketones 1a-e (1a, o-IC (6) H (4) COCH (3)) undergo carbocyclization with alkyl propiolates (2a, CH (3)(CH (2))(4) C [triple bond] CCO (2) CH (3); 2b, TMSC [triple bond] CCO (2) Et 2c, CH (3) C [triple bond] CCO (2) CH (3); 2d, CH (3) OCH (2) C [triple bond] CCO (2) CH (3); 2e, CH (3)(CH (2))(3) C [triple bond] CCO (2) CH (3); 2f, PhC [triple bond] CCO (2) CH (3); and 2g, (CH (3))(3) C [triple bond] CCO (2) CH (3)) in the presence of Ni (dppe) Br (2) and zinc powder in acetonitrile at 80 degrees C to afford the corresponding indenol derivatives 3a-m with remarkable regioselectivity in good to excellent yields.
1(0,0,0,1) Details
17637962 Ferdani R, Li R, Pajewski R, Pajewska J, Winter RK, Gokel GW: Transport of chloride and carboxyfluorescein through phospholipid vesicle membranes by heptapeptide amphiphiles. Org Biomol Chem. 2007 Aug 7;5(15):2423-32. Epub 2007 Jun 25.


Seven synthetic anion transporters (SAT) of the general form R (2) N-COCH (2) OCH (2) CO-(Gly)(3)-Pro-(Gly)(3)-OR' were prepared.
1(0,0,0,1) Details
19633728 Djedovic N, Ferdani R, Harder E, Pajewska J, Pajewski R, Weber ME, Schlesinger PH, Gokel GW: The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid Bilayers. New J Chem. 2005 Jan 1;29(2):291-305.


The synthetic peptide, R (2) N-COCH (2) OCH (2) CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR', was shown to be selective for Cl (-) over K (+) when R is n-octadecyl and R' is benzyl.
1(0,0,0,1) Details
19169373 Ferdani R, Pajewski R, Djedovic N, Pajewska J, Schlesinger PH, Gokel GW: Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels. New J Chem. 2005;29:673-280.


Chloride and carboxyfluorescein release from phospholipid vesicles was studied with the result that C (10) H (21) N (C (2) H (5)) COCH (2) OCH (2) CO-NH-(Gly)(3) Leu (Gly)(3)-OCH (2) Ph was the most active.
1(0,0,0,1) Details
14982463 Ochiai M, Lin YS, Yamada J, Misawa H, Arai S, Matsumoto K: Reactions of a platinum (III) dimeric complex with alkynes in water: novel approach to alpha-aminoketone, alpha-iminoketone, and alpha,beta-diimine via ketonyl-Pt (III) dinuclear complexes. J Am Chem Soc. 2004 Mar 3;126(8):2536-45.


Internal alkyne 2-butyne reacted with 1 to form the complex [Pt (2)(NH (3))(4)((CH (3))(3) CCONH)(2)(CH (CH (3)) COCH (3))](NO (3))(3) (12).
1(0,0,0,1) Details