| Name | CD1 |
|---|---|
| Synonyms | CD1; CD1A; CD1C; CD1c antigen; CD1c molecule; R7; T cell surface glycoprotein CD1c; T cell surface glycoprotein CD1c precursor… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16323834 | Ndonye RM, Izmirian DP, Dunn MF, Yu KO, Porcelli SA, Khurana A, Kronenberg M, Richardson SK, Howell AR: Synthesis and evaluation of analogues of KRN7000 and OCH. J Org Chem. 2005 Dec 9;70(25):10260-70. [structures: see text] The -containing alpha-galactosylceramides (alpha-GalCers), KRN7000 and OCH, have been shown to activate NKT cells via interaction with CD1d, a member of the CD1 family of antigen presenting proteins. |
1(0,0,0,1) | Details |
| 14965307 | Yamamura T, Miyamoto K, Illes Z, Pal E, Araki M, Miyake S: NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease. Curr Top Med Chem. 2004;4(5):561-7. Although T cells were previously believed to recognize only peptide antigen associated with the major histocompatibility complex (MHC), recent studies have shown that there are unique T cells specialized for recognition of lipid or glycolipid antigens bound to the MHC class I-like CD1 molecules (CD1a, b, c or d). |
1(0,0,0,1) | Details |
| 16982895 | Zajonc DM, Ainge GD, Painter GF, Severn WB, Wilson IA: Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. J Immunol. 2006 Oct 1;177(7):4577-83. Compared with other CD1d-sphingolipid structures, PIM2 has an increased number of polar interactions between its headgroup and CD1, but reduced specificity for the diacylglycerol backbone. |
1(0,0,0,1) | Details |