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Oshiro Y, Piper CE, Balwierz PS, Soelter SG: Chinese hamster ovary cell assays for mutation and chromosome damage: data from non-carcinogens. J Appl Toxicol. 1991 Jun;11(3):167-77.
Hence, we selected ten compounds deemed non-carcinogens in the literature to test for the induction of gene mutation and chromosomal damage using the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase (CHO/HGPRT) mutation assay performed concurrently with a CHO micronucleus assay.
The non-carcinogens chosen were 4-nitro-o-phenylenediamine, p-phenylenediamine dihydrochloride, 3-nitropropionic acid, dichlorvos, 2-(chloromethyl) pyridine, N-(1-naphthyl) ethylenediamine 2HCl, O-anthranilic acid, 4-nitroanthranilic acid, anilazine and triphenyltin hydroxide. |
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