| Name | CIP1 |
|---|---|
| Synonyms | CAP20; CDKN1A; Cip1; PIC 1; PIC1; P21; CDK interacting protein 1; CDK interaction protein 1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11807808 | Kim JY, Choi JA, Kim TH, Yoo YD, Kim JI, Lee YJ, Yoo SY, Cho CK, Lee YS, Lee SJ: Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. J Cell Physiol. 2002 Jan;190(1):29-37. These data demonstrate a possible link between the activation of p38MAPK and induction of p21 (CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite. |
33(0,1,1,3) | Details |
| 16797887 | Suzuki T, Tsukamoto I: Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy. Toxicol Lett. 2006 Sep 10;165(3):257-64. Epub 2006 May 12. To investigate the effects of arsenite on cell proliferation and the signal transduction in hapatocytes in vivo, rats received a single injection of sodium arsenite immediately after partial hepatectomy. The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21 (WAF1/CIP1) in the partially hepatectomized liver. |
2(0,0,0,2) | Details |
| 15734884 | Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF Jr: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H99-H107. Epub 2005 Feb 25. In this study, we sought to explore the signaling pathway triggered by sodium arsenite and its implication for endothelial phenotype. |
4(0,0,0,4) | Details |
| 20000476 | Salazar AM, Miller HL, McNeely SC, Sordo M, Ostrosky-Wegman P, States JC: Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy. Chem Res Toxicol. 2010 Feb 15;23(2):357-64. Cells were exposed to the environmental carcinogen sodium arsenite (15 and 20 microM), and the induction of micronuclei (MN) was evaluated in binucleated cells using the cytokinesis-block assay. |
4(0,0,0,4) | Details |
| 12208374 | Huang HS, Chang WC, Chen CJ: Involvement of reactive species in arsenite-induced downregulation of phospholipid hydroperoxide peroxidase in human epidermoid carcinoma A431 cells. Free Radic Biol Med. 2002 Sep 15;33(6):864-73. In the present study, we found that sodium arsenite induced downregulation of mRNA, protein expression, and enzyme activity of PHGPx in time- and dose-dependent manners. At the same time, it upregulated mRNA and protein expression of p21 (WAF1/CIP1). |
3(0,0,0,3) | Details |
| 11812925 | Wauson EM, Langan AS, Vorce RL: Sodium arsenite inhibits and reverses expression of adipogenic and fat cell-specific genes during in vitro adipogenesis. Toxicol Sci. 2002 Feb;65(2):211-9. Arsenic also blocks upregulation of p21 (Cip1/Waf1), a factor whose expression is tightly regulated during adipogenesis. |
2(0,0,0,2) | Details |