| Name | pyruvate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | Pyruvate dehydrogenase; Pyruvate dehydrogenases |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6687396 | Hsu CA, Aposhian HV, Heydolph S, Parr W: Optical isomers of 2,3-dimercapto-1-propanesulfonate: antidotal activity, in vitro and in vivo, against sodium arsenite. J Pharmacol Exp Ther. 1983 Feb;224(2):314-8. In addition, when pyruvate dehydrogenase is inhibited, in vitro, by sodium arsenite, any of the three DMPS preparations will reverse the inhibition equally well. |
112(1,2,2,2) | Details |
| 6327446 | Aposhian HV, Carter DE, Hoover TD, Hsu CA, Maiorino RM, Stine E: DMSA, DMPS, and DMPA--as arsenic antidotes. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S58-70. The sodium arsenite inhibition of the pyruvate dehydrogenase (PDH) complex can be prevented and reversed in vitro or in vivo by DMPS, DMSA, DMPA, or BAL. |
81(1,1,1,1) | Details |
| 6474464 | Stine ER, Hsu CA, Hoover TD, Aposhian HV, Carter DE: N-(2,3-dimercaptopropyl) phthalamidic acid: protection, in vivo and in vitro, against arsenic intoxication. Toxicol Appl Pharmacol. 1984 Sep 15;75(2):329-36. The effectiveness of DMPA in reducing the toxicity of NaAsO2 was further demonstrated by its reversal of the sodium arsenite inhibition of pyruvate dehydrogenase multienzyme complex (PDH) activity in vitro. |
81(1,1,1,1) | Details |
| 6772148 | Broome MC, Thomas MP, Hillier AJ, Jago GR: Pyruvate dehydrogenase activity in group N streptococci. Aust J Biol Sci. 1980 Mar;33(1):15-25. |
2(0,0,0,2) | Details |
| 12633610 | Lib M, Rodriguez-Mari A, Marusich MF, Capaldi RA: Immunocapture and microplate-based activity measurement of mammalian pyruvate dehydrogenase complex. Anal Biochem. 2003 Mar 1;314(1):121-7. |
2(0,0,0,2) | Details |
| 7103952 | Sale GJ, Randle PJ: Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria. Biochem J. 1982 Apr 1;203(1):99-108. |
2(0,0,0,2) | Details |
| 11409934 | Petrick JS, Jagadish B, Mash EA, Aposhian HV: Monomethylarsonous acid (MMA (III)) and arsenite: LD (50) in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem Res Toxicol. 2001 Jun;14(6):651-6. MMA (III), like sodium arsenite, contains arsenic in the +3 oxidation state. |
2(0,0,0,2) | Details |
| 10653439 | Mitchell RD, Ayala-Fierro F, Carter DE: Systemic indicators of inorganic arsenic toxicity in four animal species. J Toxicol Environ Health A. 2000 Jan 28;59(2):119-34. Five prospective biological indicators of systemic toxicity were examined at time points ranging from 15 min to 24 h using male Sprague-Dawley rats, B6C3F1 mice, Golden-Syrian hamsters, and Hartley guinea pigs, following intraperitoneal dosing with 0.1 and 1 mg/kg sodium arsenite. Renal pyruvate dehydrogenase activity was significantly decreased at early time points in mice, hamsters, and guinea pigs, and at later time points in rats dosed with arsenite. |
1(0,0,0,1) | Details |
| 6306868 | Aposhian HV, Hsu CA, Hoover TD: DL- and meso-dimercaptosuccinic acid: in vitro and in vivo studies with sodium arsenite. Toxicol Appl Pharmacol. 1983 Jun 30;69(2):206-13. The two forms of DMSA are equally effective in preventing or reversing, in vitro, the arsenite inhibition of the activity of mouse kidney pyruvate dehydrogenase (PDH) complex, DL-DMSA, however, is superior to meso-DMSA for the in vivo reversal of PDH activity as measured in vitro. |
1(0,0,0,1) | Details |
| 8786242 | Xu DP, Wells WW: dependent regeneration of from in rat liver mitochondria. J Bioenerg Biomembr. 1996 Feb;28(1):77-85. The reactions were strongly inhibited by 1 mM iodoacetamide or sodium arsenite. Pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase reduced to in an and or alpha-ketoglutarate dependent fashion. |
1(0,0,0,1) | Details |
| 12901003 | Samokhvalov VA, Museikina NIu, Mel'nikov GV, Ignatov VV: [Arsenite-induced lipid peroxidation in Saccharomyces cerevisiae] . Mikrobiologiia. 2003 May-Jun;72(3):308-11. The ability of sodium arsenite at concentrations of 10 (-2), 10 (-4), and 10 (-6) M to induce lipid peroxidation in Saccharomyces cerevisiae cells was studied. All of the tested arsenite concentrations inhibited the activity of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase in cells. |
1(0,0,0,1) | Details |