Protein Information

Name CHOP
Synonyms 75 kDa DNA pairing protein; FUS1; CHOP; FUS; FUS 1; FUS CHOP; FUS/ATF1fusion gene; FUS/CHOP fusion gene…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
10542372 Fontanier-Razzaq NC, Hay SM, Rees WD: Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress. Mol Reprod Dev. 1999 Dec;54(4):326-32.

When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin.
93(1,1,2,8) Details
11145585 Entingh AJ, Law BK, Moses HL: Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology. 2001 Jan;142(1):221-8.

LY294002 and rapamycin are also able to block CHOP induction by hydrogen peroxide, but do not affect expression induced by sodium arsenite or A23187.
7(0,0,0,7) Details
11319142 Fontanier-Razzaq N, McEvoy TG, Robinson JJ, Rees WD: DNA damaging agents increase gadd153 (CHOP-10) messenger RNA levels in bovine preimplantation embryos cultured in vitro. Biol Reprod. 2001 May;64(5):1386-91.

Treatment of bovine granulosa cell cultures with the DNA-damaging agents, methyl methane-sulphonate (MMS) or sodium arsenite, induced the expression of an mRNA, which hybridized with the hamster gadd153 cDNA.
2(0,0,0,2) Details
17681577 Lin AM, Chao PL, Fang SF, Chi CW, Yang CH: Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):138-46. Epub 2007 Jul 3.

In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels.
The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain.
1(0,0,0,1) Details