| Name | aryl hydrocarbon receptor |
|---|---|
| Synonyms | AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11042089 | Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF: Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):177-82. These results indicate the induction of CYP1A4 and 1A5 is inhibited by sodium arsenite at the level of transcription, suggesting that the Ah receptor complex may be involved. |
31(0,1,1,1) | Details |
| 16274885 | Elbekai RH, El-Kadi AO: The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free Radic Biol Med. 2005 Dec 1;39(11):1499-511. Epub 2005 Aug 9. |
2(0,0,0,2) | Details |
| 18474416 | Elbekai RH, El-Kadi AO: Arsenite and cadmium, but not induce NAD (P) H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications. Toxicol In Vitro. 2008 Aug;22(5):1184-90. Epub 2008 Mar 31. Metals alter the carcinogenicity of AhR ligands, such as TCDD, by modulating the induction of Nqo1, but the mechanism (s) remain unresolved. |
1(0,0,0,1) | Details |
| 16713074 | Chao HR, Tsou TC, Li LA, Tsai FY, Wang YF, Tsai CH, Chang EE, Miao ZF, Wu CH, Lee WJ: Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells. J Hazard Mater. 2006 Sep 21;137(2):716-22. Epub 2006 Apr 25. The aim of this study was to examine the arsenic effect on activation of aryl hydrocarbon receptor (AhR)-mediated gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in human hepatoma cells. The human hepatoma Huh7 cells were treated with sodium arsenite (NaAsO2) from 0.5 to 20 microM for 24 h. |
1(0,0,0,1) | Details |
| 11979425 | Seubert JM, Sinal CJ, Bend JR: Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat. J Biochem Mol Toxicol. 2002;16(2):84-95. |
0(0,0,0,0) | Details |