Protein Information

Name SUR2
Synonyms ABC37; SUR 2; SUR2; ABCC 9; ABCC9; ATP binding cassette transporter sub family C member 9; CMD1O; Sulfonylurea receptor 2…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
18511652 Adebiyi A, McNally EM, Jaggar JH: Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Mol Pharmacol. 2008 Sep;74(3):736-43. Epub 2008 May 29.

Ryanodine (10 microM), a ryanodine-sensitive Ca2+ release (RyR) channel blocker; iberiotoxin (100 nM), a large-conductance Ca2+-activated K+ (KCa) channel blocker; 4-aminopyridine (4-AP; 1 mM), a voltage-gated K+ (KV) channel blocker; manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (MnTMPyP; 100 microM), an antioxidant; and a combination of ryanodine and 4-AP reduced diazoxide (100 microM)-induced dilation in pressurized (60 mm Hg) SUR2 (+/+) arteries by 45 to 77%.
34(0,1,1,4) Details
11165940 Gu Y, Preston MR, El Haj AJ, Howl JD, Publicover SJ: Three types of K (+) currents in murine osteocyte-like cells (MLO-Y4). Bone. 2001 Jan;28(1):29-37.


Message for the sulphonylurea receptor SUR2, a subunit of glibenclamide-insensitive ATP-dependent K (+) channels (K (ATP)), was also detected, but the glibenclamide-sensitive SUR1 subunit was not.
1(0,0,0,1) Details