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4-aminopyridine

Identification (Source:EPA,EU)

ID	332
Name	4-aminopyridine
CAS	504-24-5
IUPAC	pyridin-4-amine
Inchi	InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
CIPAC	None allocated
EPA Code	069201
Formula	C5H6N2
SMILES	c1(ccncc1)N
Status	Not Available

Classification

Mode of Action	Works as a potassium channel blocker, over stimulating the nervous system
Pesticide Type	Avicide, Acaricide, Repellent
Chemical Group	Isomeric amine of pyridine
Classification	Avicides

Properties (Source:PubChem)

Molecular Weight	94.13
Physical State	White crystalline solid
AlogP	-0.068
H-Bond Donor	1
H-Bond Acceptor	2
Surface Area	104.31
Polar Surface Area	38.9

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Aquatic invertebrates	Acute	48 hour	EC50	3.2 mg l-1
Birds	Acute		LD50	722 mg kg-1
Fish	Acute	96 hour	LC50	3.4 mg l-1
Mammals	Acute oral		LD50	29 mg kg-1

Related targets

Target Name	RScore (About this table)
Potassium channel (protein family or complex)	2571(5,60,110,271)	Details
CA3	805(5,11,27,145)	Details
protein kinase C (protein family or complex)	475(4,7,7,65)	Details
NMDA receptors (protein family or complex)	546(3,10,11,91)	Details
glutamate receptor	361(2,7,7,51)	Details
angiotensin II	280(2,4,4,60)	Details
GABA B receptors	233(2,3,3,43)	Details
glutamate receptors (protein family or complex)	201(2,2,3,36)	Details
episodic ataxia type 2	189(2,2,4,19)	Details
voltage gated K channel (protein family or complex)	179(2,2,3,14)	Details
parvalbumin	177(2,2,3,12)	Details
cholinesterase	169(2,2,2,9)	Details
epidermal growth factor receptor	166(2,2,2,6)	Details
CA1	520(1,8,17,185)	Details
voltage gated potassium channel	385(1,8,14,65)	Details
beta 3 adrenoceptors	227(1,5,6,22)	Details
muscles	273(1,4,7,88)	Details
AP 2	181(1,3,8,16)	Details
caspase (protein family or complex)	151(1,3,3,11)	Details
estrogen receptor	148(1,3,3,8)	Details
KCNA5	142(1,2,4,22)	Details
cAMP dependent protein kinase (protein family or complex)	142(1,2,3,27)	Details
beta adrenoceptors (protein family or complex)	138(1,2,2,28)	Details
SNAP	134(1,2,3,19)	Details
adenylate cyclase	118(1,2,2,8)	Details
purinergic receptor	112(1,2,2,2)	Details
KChIP2	113(1,1,2,28)	Details
Substance P	103(1,1,2,18)	Details
TREK 1	103(1,1,2,18)	Details
potassium ion channels	103(1,1,3,13)	Details
leptin	100(1,1,2,15)	Details
phospholipase C	99(1,1,2,14)	Details
mitogen activated protein kinase (protein family or complex)	99(1,1,1,19)	Details
catalase	96(1,1,1,16)	Details
pituitary adenylate cyclase activating polypeptide	95(1,1,2,10)	Details
olfactory receptor	92(1,1,1,12)	Details
IL 1beta	91(1,1,1,11)	Details
dopamine transporter	91(1,1,2,6)	Details
c kit	88(1,1,1,8)	Details
mcl 1	88(1,1,1,8)	Details
TRPV1	86(1,1,1,6)	Details
hASCs	86(1,1,1,6)	Details
integrin	85(1,1,1,5)	Details
KCNA1	85(1,1,1,5)	Details
gephyrin	85(1,1,1,5)	Details
aquaporin 1	84(1,1,1,4)	Details
HK2	83(1,1,1,3)	Details
interferon gamma	83(1,1,1,3)	Details
TRIM	82(1,1,1,2)	Details
alpha2 adrenoceptor (protein family or complex)	82(1,1,1,2)	Details
brain 4	82(1,1,1,2)	Details
adenosine kinase	82(1,1,1,2)	Details
laminin (protein family or complex)	82(1,1,1,2)	Details
proline rich tyrosine kinase 2	81(1,1,1,1)	Details
MAP4	81(1,1,1,1)	Details
AP 1 (protein family or complex)	373(0,11,15,23)	Details
calcium channel (protein family or complex)	206(0,5,6,51)	Details
guanylate cyclase	176(0,5,5,26)	Details
Acetylcholinesterase	111(0,3,3,21)	Details
adenosine A1 receptor	97(0,3,3,7)	Details
c fos	120(0,2,7,35)	Details
G protein	100(0,2,2,40)	Details
CB1 receptors	90(0,2,2,30)	Details
KCa1.1	89(0,2,2,29)	Details
AP 4	87(0,2,4,17)	Details
PACAP	87(0,2,2,27)	Details
mu opioid receptors	85(0,2,2,25)	Details
adenylyl cyclase	76(0,2,2,16)	Details
neuropeptide Y	76(0,2,3,11)	Details
GABA receptor (protein family or complex)	75(0,2,2,15)	Details
cytochrome P450 (protein family or complex)	69(0,2,2,9)	Details
TASK	84(0,1,1,54)	Details
ATPase	64(0,1,2,29)	Details
kininogen	55(0,1,2,20)	Details
endothelin 1	54(0,1,2,19)	Details
ERK1	53(0,1,2,18)	Details
sodium channel (protein family or complex)	51(0,1,1,21)	Details
AP 3 (protein family or complex)	50(0,1,3,10)	Details
mGluR5	47(0,1,1,17)	Details
glycine receptors (protein family or complex)	41(0,1,2,6)	Details
P13	41(0,1,2,6)	Details
complex I	40(0,1,1,10)	Details
bcl 2	39(0,1,1,9)	Details
SAP97	39(0,1,1,9)	Details
PP2	38(0,1,1,8)	Details
homer1	37(0,1,1,7)	Details
aquaporin 4	37(0,1,1,7)	Details
ET A	36(0,1,1,6)	Details
SCLC	36(0,1,1,6)	Details
TRPV2	36(0,1,1,6)	Details
Ach 1	35(0,1,1,5)	Details
NPPB	35(0,1,1,5)	Details
TRAM	35(0,1,1,5)	Details
GABA transporter	35(0,1,1,5)	Details
SUR2	35(0,1,1,5)	Details
cytochrome c	35(0,1,1,5)	Details
NHE1	34(0,1,1,4)	Details
TRPC6	34(0,1,1,4)	Details
FB1	34(0,1,1,4)	Details
myelin basic protein	34(0,1,1,4)	Details
eag	33(0,1,1,3)	Details
c Jun N terminal kinase (protein family or complex)	33(0,1,1,3)	Details
modulatory calcineurin interacting proteins	33(0,1,1,3)	Details
PDE3	33(0,1,1,3)	Details
GABA at	33(0,1,1,3)	Details
AT2	33(0,1,1,3)	Details
ERK2	32(0,1,1,2)	Details
P23	32(0,1,1,2)	Details
integrator (protein family or complex)	32(0,1,1,2)	Details
activated protein C	31(0,1,1,1)	Details
SOD1	31(0,1,1,1)	Details
ATP 3	31(0,1,1,1)	Details
CYP2C9	31(0,1,1,1)	Details
somatostatin	30(0,0,1,25)	Details
Cx36	26(0,0,2,16)	Details
neurotrophin	24(0,0,0,24)	Details
calcitonin gene related peptide	24(0,0,0,24)	Details
acetylcholine receptor (protein family or complex)	20(0,0,0,20)	Details
TRESK 2	18(0,0,1,13)	Details
phosphodiesterase	17(0,0,0,17)	Details
TASK3	16(0,0,0,16)	Details
KCa3.1	15(0,0,0,15)	Details
OBCAM	15(0,0,1,10)	Details
HM 1	15(0,0,1,10)	Details
5 HT2A	14(0,0,0,14)	Details
G alpha q	14(0,0,1,9)	Details
TASK 2	13(0,0,0,13)	Details
Ca v	13(0,0,0,13)	Details
SCA1	13(0,0,1,8)	Details
calmodulin	13(0,0,0,13)	Details
SIVA	13(0,0,2,3)	Details
MKL1	12(0,0,0,12)	Details
KCNQ1	12(0,0,0,12)	Details
p38	12(0,0,0,12)	Details
mGluR1	12(0,0,0,12)	Details
Rho kinase	11(0,0,0,11)	Details
RAPSN	11(0,0,0,11)	Details
NF2	11(0,0,1,6)	Details
protein phosphatase 2B (protein family or complex)	11(0,0,0,11)	Details
SK3	11(0,0,0,11)	Details

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