Protein Information

Name PACAP
Synonyms Caspase 2 binding protein; PACAP; HSPC190; PACAP protein; Proapoptotic caspase adaptor protein; PACAP proteins; Proapoptotic caspase adaptor proteins

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
17498241 Xu F, Tse FW, Tse A: Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current. J Neurochem. 2007 Jun;101(5):1284-93.

In the presence of tetraethylammonium (TEA) and 4-aminopyridine (4-AP), PACAP reduced a background K (+) current.
39(0,1,1,9) Details
11259781 Miura A, Kawatani M, de Groat WC: Effects of pituitary adenylate cyclase activating polypeptide on lumbosacral preganglionic neurons in the neonatal rat spinal cord. Brain Res. 2001 Mar 23;895(1-2):223-32.

PACAP suppressed a transient outward current that was also suppressed by 4-aminopyridine (0.5 mM).
36(0,1,1,6) Details
15066141 Mei YA, Vaudry D, Basille M, Castel H, Fournier A, Vaudry H, Gonzalez BJ: PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58.

12(0,0,0,12) Details