| Name | TASK3 |
|---|---|
| Synonyms | Acid sensitive potassium channel protein TASK 3; KCNK 9; KCNK9; KT3.2; Potassium channel TASK3; Potassium channel subfamily K member 9; TASK 3; TASK3… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15733086 | Larkman PM, Perkins EM: A TASK-like pH- and amine-sensitive 'leak' K+ conductance regulates neonatal rat facial motoneuron excitability in vitro. Eur J Neurosci. 2005 Feb;21(3):679-91. Although the molecular identity of gK (Leak) is unknown, TASK-1 and TASK-3 channel mRNA is found in facial motoneurons. Ba2+, Cs+ and Rb+ blocked I (NA) and I (pH) voltage-dependently with maximal block at hyperpolarized potentials. 4-Aminopyridine (4-AP, 4 mM) voltage-independently blocked I (NA) and I (pH). |
3(0,0,0,3) | Details |
| 16421215 | Barfield JP, Yeung CH, Cooper TG: Characterization of channels involved in volume regulation of human spermatozoa. Mol Hum Reprod. 2005 Dec;11(12):891-7. Epub 2006 Jan 18. Regulation of cellular volume, as measured by flow cytometry, was inhibited when spermatozoa were exposed to quinine (QUI; 0.3 mM), 4-aminopyridine (4AP; 4 mM) and clofilium (CLO; 10 microM) which suggests the involvement of voltage-gated K+ channels Kv1.4, Kv1.5 and Kv1.7, acid-sensitive channel TASK2 and the beta-subunit minK (IsK) in regulatory volume decrease (RVD). Although Kv1.4, Kv1.7, TASK2 and TASK3 channels may have important roles in human spermatozoa, Kv1.5 and minK appear to be the most likely candidates for human sperm RVD, serving as targets for non-hormonal contraception. |
1(0,0,0,1) | Details |
| 14504065 | Williams BA, Buckler KJ: Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L221-30. Epub 2003 Sep 22. In the absence of extracellular divalent cations, however, single channel conductance increased to 28 pS in a manner similar to that reported for TASK-3. |
1(0,0,0,1) | Details |
| 17659475 | Mathie A, Veale EL: Therapeutic potential of neuronal two-pore domain potassium-channel modulators. Curr Opin Investig Drugs. 2007 Jul;8(7):555-62. Although not inhibited by classical potassium channel-blocking drugs, such as tetraethylammonium and 4-aminopyridine, K2P channels are regulated by a diverse array of pharmacological mediators. Furthermore, all members of the TASK family are inhibited by cannabinoids and local anesthetics, and TASK-3 is selectively inhibited by ruthenium red. |
1(0,0,0,1) | Details |
| 11897089 | Gnatenco C, Han J, Snyder AK, Kim D: Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes. Brain Res. 2002 Mar 22;931(1):56-67. Reverse transcriptase-PCR analysis showed that, among five 4TM/2P K+ channels examined, TASK-1, TASK-3 and TREK-2 mRNAs were expressed in cultured astrocytes from rat cortex. The 117 pS K+ channel also showed inward rectification and was insensitive to 1 mM tetraethylammonium and 1 mM 4-aminopyridine. |
1(0,0,0,1) | Details |
| 11431495 | Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B: KT3.2 and KT3.3, two novel human two-pore K (+) channels closely related to TASK-1. J Neurophysiol. 2001 Jul;86(1):130-42. |
8(0,0,0,8) | Details |
| 15673604 | Barfield JP, Yeung CH, Cooper TG: The effects of putative K+ channel blockers on volume regulation of murine spermatozoa. Biol Reprod. 2005 May;72(5):1275-81. Epub 2005 Jan 26. The presence of quinine (0.8 mM), cadmium (0.2 mM), flecainide (100 microM), 4-aminopyridine (4 mM), barium (1 mM), clofilium (10 microM), and phrixotoxin (100 nM) for 75 min resulted in significantly higher forward scatter values than sperm incubated in medium without an inhibitor. These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), and acid-sensitive TASK2 (KCNK5) and TASK3 (KCNK9). |
1(0,0,0,1) | Details |