Protein Information

Name alpha2 adrenoceptor (protein family or complex)
Synonyms Alpha adrenoceptor; Alpha adrenoceptor; Alpha adrenergic receptor; Alpha adrenergic receptors; Alpha adrenoceptors; Alpha adrenoceptors; alpha1 Adrenoceptors; alpha1 Adrenoceptor…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
12630545 Jones RL, Shum WW, Gurney AM: Synergism between prostanoids and other vasoactive agents. J Card Surg. 2002 Sep-Oct;17(5):436-8.

In contrast, threshold sulprostone responses were dramatically enhanced in the presence of established small contractions to phenylephrine (alpha1-adrenoceptor agonist), U-46619 (TP agonist), cyclopiazonic acid (sarcoplasmic Ca2+ pump inhibitor), and 4-aminopyridine (4-AP, Kv channel blocker).
81(1,1,1,1) Details
15631089 Dong K, Tao QM, Xia Q, Shan QX, Pan GB: [Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta]. Zhongguo Zhong Yao Za Zhi. 2004 Oct;29(10):981-4.


The relaxant effect of puerarin was significantly inhibited by pretreatment of endothelium-denuded aorta with potassium channel antagonists tetraethylammonium, 4-aminopyridine but not glibenclamide.
0(0,0,0,0) Details
10610260 Jiang F, Li CG, Rand MJ: Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery. Clin Exp Pharmacol Physiol. 1999 Oct;26(10):364-70.


The inhibition of nitrergic relaxations by 3 micromol/L ACh was prevented by the K+ channel blockers tetraethylammonium and 4-aminopyridine, but was not changed by iberiotoxin, apamin or glibenclamide. 4.
0(0,0,0,0) Details
17379634 Tan JH, Al Abed A, Brock JA: Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors. J Physiol. 2007 Jun 1;581(Pt 2):757-65. Epub 2007 Mar 22.

A high concentration of Ba (2+)(1 mM), which would be expected to block K (ATP) channels, abolished the NAD, whereas teteraethylammonium (1 mM) and 4-aminopyridine (1 mM) increased its amplitude.
1(0,0,0,1) Details