| Name | AT2 |
|---|---|
| Synonyms | AGTR 2; AGTR2; AT2; ATGR 2; ATGR2; Angiotensin II receptor type 2; MRX88; Type 2 angiotensin II receptor… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16543267 | Ma X, Bielefeldt K, Tan ZY, Whiteis CA, Snitsarev V, Abboud FM, Chapleau MW: Dual mechanisms of angiotensin-induced activation of mouse sympathetic neurones. J Physiol. 2006 May 15;573(Pt 1):45-63. Epub 2006 Mar 16. The IA channel blocker 4-aminopyridine triggered AP generation in TNs and prevented the Ang II-induced APs but not the depolarization. |
0(0,0,0,0) | Details |
| 16042987 | Gendron G, Gobeil F Jr, Belanger S, Gagnon S, Regoli D, D'Orleans-Juste P: Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats. Peptides. 2005 Aug;26(8):1468-74. These include the non-selective synthase inhibitor L-NAME (5 micromol/kg), the non-selective cyclooxygenase inhibitor meclofenamate (16 micromol/kg), the voltage-sensitive and ATP-sensitive K+-channel inhibitors, 4-aminopyridine (5 micromol/kg) and glybenclamide (10 micromol/kg), the cytochrome P450 CYP2C9 inhibitor sulfaphenazole (15 micromol/kg), the cytoskeletal fixation agent phalloidin (15 micromol/kg), the endothelin ETB receptor antagonist BQ-788 (35 micromol/kg), the bradykinin B2 receptor antagonist HOE 140 (0.5 micromol/kg), the angiotensin AT2 antagonist PD 123319 (10 micromol/kg) and the UT receptor antagonist urantide (10 micromol/kg). |
31(0,1,1,1) | Details |
| 15654262 | Fukada SY, Tirapelli CR, de Godoy MA, de Oliveira AM: Mechanisms underlying the endothelium-independent relaxation induced by angiotensin II in rat aorta. J Cardiovasc Pharmacol. 2005 Feb;45(2):136-43. The combination of L-NAME, indomethacin, and TEA completely abolished the relaxation induced by angiotensin II. 4-Aminopyridine (4-AP) as well as charybdotoxin reduced angiotensin II-induced relaxation. The selective antagonist of AT2 receptors, PD123319, inhibited angiotensin II-induced relaxation. |
1(0,0,0,1) | Details |
| 14757704 | Soares de Moura R, Resende AC, Emiliano AF, Tano T, Mendes-Ribeiro AC, Correia ML, de Carvalho LC: The role of bradykinin, AT2 and angiotensin 1-7 receptors in the EDRF-dependent vasodilator effect of angiotensin II on the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 2004 Mar;141(5):860-6. Epub 2004 Feb 2. However, this effect is not affected by ATP and voltage-dependent K (+) channel blockers (glybenclamide and 4-aminopyridine). 5. |
1(0,0,0,1) | Details |