Protein Information

Name P23
Synonyms CDK5 activator 1; P25; p35; P23; CDK5P35; CDK5R; CDK5R1; Cyclin dependent kinase 5 activator 1…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
11412897 Wong M, Yamada KA: Developmental characteristics of epileptiform activity in immature rat neocortex: a comparison of four in vitro seizure models. Brain Res Dev Brain Res. 2001 Jun 29;128(2):113-20.

The present study investigated developmental changes in epileptiform activity in rat neocortical slices from four age groups (postnatal days P4--7, P13--16, P23--26, P41--47) due to four pharmacological conditions (4-aminopyridine, low magnesium, picrotoxin, CGP-35348) that differentially modulate glutamate and GABA systems.
31(0,1,1,1) Details
18234240 Pedroarena CM, Kamphausen S: Glycinergic synaptic currents in the deep cerebellar nuclei. . Neuropharmacology. 2008 Apr;54(5):784-95. Epub 2007 Dec 23.

Spontaneous glycinergic IPSCs were very rare but direct presynaptic depolarization by superfusion with elevated potassium concentration or application of 4-aminopyridine consistently evoked strychnine sensitive IPSCs.
Immuno-histochemical investigations using a specific marker for glycinergic fibers and terminals showed low density of immuno-fluorescent puncta, putative glycinergic boutons surrounding P18-P23 DCNs, in agreement with the rare spontaneous synaptic activity.
1(0,0,0,1) Details