Protein Information

Name neurotrophin
Synonyms Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
11599006 Numakawa T, Matsumoto T, Adachi N, Yokomaku D, Kojima M, Takei N, Hatanaka H: Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca (2+) and Na (+) in cultured cerebellar neurons. J Neurosci Res. 2001 Oct 1;66(1):96-108.

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19344696 Leng J, Jiang L, Chen H, Zhang X: Brain-derived neurotrophic factor and electrophysiological properties of voltage-gated ion channels during neuronal stem cell development. Brain Res. 2009 May 26;1272:14-24. Epub 2009 Apr 1.

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17005865 Kalita K, Kharebava G, Zheng JJ, Hetman M: Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. J Neurosci. 2006 Sep 27;26(39):10020-32.

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18689502 Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX: p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1529-38. Epub 2008 Aug 8.

Active tension induced by serotonin, U-46619 (a thromboxane A (2) analog), thrombin, 4-aminopyridine (a K (+) channel blocker), and high extracellular K (+) in p75 (-/-) rings was similar to that in WT rings.
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16183639 Lenz G, Avruch J: Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. . J Biol Chem. 2005 Nov 18;280(46):38121-4. Epub 2005 Sep 22.

Brief glutamatergic stimulation of neurons from fetal mice, cultured in vitro for 6 days, activates the mTOR-S6 kinase, ERK1/2 and Akt pathways, to an extent approaching that elicited by brain-derived neurotrophic factor.
After 12 days in culture, the response to direct glutamatergic activation is attenuated but can be uncovered by suppression of gamma-aminobutyric acid interneurons with bicuculline in the presence of the weak K (+) channel blocker 4-aminopyridine (4-AP).
1(0,0,0,1) Details