Protein Information

Name SIVA
Synonyms Apoptosis regulatory protein Siva; CD27 binding protein; CD27 binding (Siva) protein; CD27BP; SIVA; CD27 binding proteins; CD27 binding (Siva) proteins

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
10640333 Smith GT, Zakon HH: Pharmacological characterization of ionic currents that regulate the pacemaker rhythm in a weakly electric fish. J Neurobiol. 2000 Feb 5;42(2):270-86.

Two potassium channel blockers, 4-aminopyridine (4AP) and kappaA-conotoxin SIVA, increased pacemaker firing rates by approximately 20% and then stopped pacemaker firing.
7(0,0,1,2) Details
16187302 Smith GT: Pharmacological characterization of ionic currents that regulate high-frequency spontaneous activity of electromotor neurons in the weakly electric fish, Apteronotus leptorhynchus. J Neurobiol. 2006 Jan;66(1):1-18.

As in pacemaker neurons, high-frequency firing of EMNs was regulated primarily by tetrodotoxin-sensitive sodium currents and by potassium currents that were sensitive to 4-aminopyridine and kappaA-conotoxin SIVA, but resistant to tetraethylammonium.
6(0,0,1,1) Details