| Name | TASK |
|---|---|
| Synonyms | Acid sensitive potassium channel protein TASK 1; KCNK 3; KCNK3; OAT 1; OAT1; Potassium channel subfamily K member 3; TASK; TASK 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15774516 | Cho SY, Beckett EA, Baker SA, Han I, Park KJ, Monaghan K, Ward SM, Sanders KM, Koh SD: A pH-sensitive conductance (TASK) and its function in the murine gastrointestinal tract. J Physiol. 2005 May 15;565(Pt 1):243-59. Epub 2005 Mar 17. The effects of lidocaine were not blocked by tetraethylammonium 4-aminopyridine, glibenclamide, apamin or MK-499. |
3(0,0,0,3) | Details |
| 17498241 | Xu F, Tse FW, Tse A: Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current. J Neurochem. 2007 Jun;101(5):1284-93. In the presence of tetraethylammonium (TEA) and 4-aminopyridine (4-AP), PACAP reduced a background K (+) current. |
3(0,0,0,3) | Details |
| 14504065 | Williams BA, Buckler KJ: Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L221-30. Epub 2003 Sep 22. |
3(0,0,0,3) | Details |
| 15066906 | Gardener MJ, Johnson IT, Burnham MP, Edwards G, Heagerty AM, Weston AH: Functional evidence of a role for two-pore domain channels in rat mesenteric and pulmonary arteries. Br J Pharmacol. 2004 May;142(1):192-202. Epub 2004 Apr 5. RT-PCR demonstrated the expression of TASK-1, TASK-2, THIK-1, TRAAK, TREK-1, TWIK-1 and TWIK-2 in mesenteric arteries and TASK-1, TASK-2, THIK-1, TREK-2 and TWIK-2 in pulmonary arteries. K (+) channel blockade by 4-aminopyridine (4-AP) (5 mm), tetraethylammonium (TEA) (10 mm), Ba (2+) (30 microm) and glibenclamide (10 microm) depolarised the pulmonary artery. |
3(0,0,0,3) | Details |
| 16914430 | Wareing M, Bai X, Seghier F, Turner CM, Greenwood SL, Baker PN, Taggart MJ, Fyfe GK: Expression and function of channels in the human placental vasculature. Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R437-46. Epub 2006 Mar 2. The expression of voltage-gated (Kv) 2.1, KV9.3, large-conductance Ca2+-activated K channel (BKCa), inward-rectified K+ channel (KIR) 6.1, and two-pore domain inwardly rectifying potassium channel-related acid-sensitive K channels (TASK) 1 in chorionic plate arteries, veins, and placental homogenate was assessed by RT-PCR and Western blot analysis. Functional activity of K channels was assessed pharmacologically in small chorionic plate arteries and veins by wire myography using 4-aminopyridine, iberiotoxin, pinacidil, and |
3(0,0,0,3) | Details |
| 11431495 | Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B: KT3.2 and KT3.3, two novel human two-pore K (+) channels closely related to TASK-1. J Neurophysiol. 2001 Jul;86(1):130-42. |
3(0,0,0,3) | Details |
| 16436472 | Xu F, Xu J, Tse FW, Tse A: stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1592-8. Epub 2006 Jan 25. Although was reported to inhibit a 4-aminopyridine (4-AP)-sensitive K+ current, 4-AP failed to trigger any [Ca2+] i rise, or to attenuate the response. In contrast, an inhibitor of the TWIK-related acid-sensitive K+-1 (TASK-1) channels, triggered depolarization and [Ca2+] i rise. |
2(0,0,0,2) | Details |
| 12640017 | Campanucci VA, Fearon IM, Nurse CA: A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. J Physiol. 2003 May 1;548(Pt 3):731-43. Epub 2003 Mar 14. More recently, acid-sensitive TASK-like background K+ channels, which play a key role in setting the resting membrane potential, have been implicated in O2-sensing in certain cell types. This conductance was insensitive to 30 mM TEA, 5 mM 4-aminopyridine (4-AP) and 200 microM Cd2+, but was reversibly inhibited by hypoxia (O2 tension (PO2) = 15 mmHg), 2-5 mM halothane, 10 mM barium and 1 mM quinidine. |
2(0,0,0,2) | Details |
| 11248242 | Decher N, Maier M, Dittrich W, Gassenhuber J, Bruggemann A, Busch AE, Steinmeyer K: Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family. FEBS Lett. 2001 Mar 9;492(1-2):84-9. TASK-4 currents were efficiently blocked by barium (83% inhibition at 2 mM), only weakly inhibited by 1 mM concentrations of quinine, bupivacaine and lidocaine, but not blocked by tetraethylammonium, 4-aminopyridine and Cs (+). TASK-4 was sensitive to extracellular pH, but in contrast to other TASK channels, pH sensitivity was shifted to more alkaline pH. |
2(0,0,0,2) | Details |
| 18394011 | Beckett EA, Han I, Baker SA, Han J, Britton FC, Koh SD: Functional and molecular identification of pH-sensitive K+ channels in murine urinary bladder smooth muscle. BJU Int. 2008 Jul;102(1):113-24. Epub 2008 Apr 3. RT-PCR showed the expression of the acid-sensitive K (+) channel (TASK)-1 and TASK-2 gene transcripts in murine bladder, and immunohistochemistry and Western blot analysis showed TASK-1 and TASK-2 channel expression and distribution in smooth muscle tissues and cells. Pre-treatment of bladder myocytes with the classical K (+) antagonists tetraethylammonium (10 mm), 4-aminopyridine (5 mM), glibenclamide (10 microm) or apamin (300 nM) did not inhibit the effects of low pH on outward current. |
2(0,0,0,2) | Details |
| 12559116 | Lesage F: Pharmacology of neuronal background channels. Neuropharmacology. 2003 Jan;44(1):1-7. In the nervous system, the main representatives of this family are the TASK and TREK channels. They are relatively insensitive to the broad-spectrum K (+) channel blockers tetraethylammonium (TEA), 4-aminopyridine (4-AP), Cs (+), and Ba (2+). |
2(0,0,0,2) | Details |
| 17659475 | Mathie A, Veale EL: Therapeutic potential of neuronal two-pore domain potassium-channel modulators. Curr Opin Investig Drugs. 2007 Jul;8(7):555-62. Although not inhibited by classical potassium channel-blocking drugs, such as tetraethylammonium and 4-aminopyridine, K2P channels are regulated by a diverse array of pharmacological mediators. Furthermore, all members of the TASK family are inhibited by cannabinoids and local anesthetics, and TASK-3 is selectively inhibited by ruthenium red. |
1(0,0,0,1) | Details |
| 11897089 | Gnatenco C, Han J, Snyder AK, Kim D: Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes. Brain Res. 2002 Mar 22;931(1):56-67. Reverse transcriptase-PCR analysis showed that, among five 4TM/2P K+ channels examined, TASK-1, TASK-3 and TREK-2 mRNAs were expressed in cultured astrocytes from rat cortex. The 117 pS K+ channel also showed inward rectification and was insensitive to 1 mM tetraethylammonium and 1 mM 4-aminopyridine. |
1(0,0,0,1) | Details |
| 16736155 | Bieger D, Parai K, Ford CA, Tabrizchi R: beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jun;373(3):186-96. Epub 2006 Apr 25. While Rp-8-Br-cAMP (30.0 microM), tetraethylammonium (0.3 & 1.0 mM), 4-aminopyridine (100 microM), (10.0 microM), charybdotoxin (0.1 microM), ouabain (100 microM), and barium (100 microM), incompletely blocked relaxation to isoprenaline, cyclopiazonic acid (1.0 microM), apamin (3.0 microM) and zinc (300 microM) were without effect. |
1(0,0,0,1) | Details |
| 19251214 | Thomsen MB, Sosunov EA, Anyukhovsky EP, Ozgen N, Boyden PA, Rosen MR: Deleting the accessory subunit KChIP2 results in loss of I (to,f) and increased I (K,slow) that maintains normal action potential configuration. Heart Rhythm. 2009 Mar;6(3):370-7. Epub 2008 Nov 27. BACKGROUND: Four voltage-gated currents, I (to,f) (K (V) 4.2), I (to,s) (K (V) 1.4), I (K,slow) (K (V) 1.5+K (V) 2.1), and I (SS) (TASK1), govern murine ventricular repolarization. RESULTS: Despite comparable baseline action potentials, APD was more markedly prolonged by 4-aminopyridine (4-AP) in KChIP2 (-/-) preparations. |
1(0,0,0,1) | Details |
| 16432512 | Gonczi M, Szentandrassy N, Johnson IT, Heagerty AM, Weston AH: Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br J Pharmacol. 2006 Mar;147(5):496-505. The application of levcromakalim (10 microM), NS1619 (33 microM) and a potassium channel inhibitor cocktail (5 mM 4-aminopyridine, 10 mM tetraethylammonium 30 microM Ba2+ and 10 microM glibenclamide) had similar effects in control and in siRNA-transfected vessels. The TASK-1 -sensitive) contribution to resting membrane potential was comparable in each group. |
1(0,0,0,1) | Details |
| 15322267 | Choisy SC, Hancox JC, Arberry LA, Reynolds AM, Shattock MJ, James AF: Evidence for a novel K (+) channel modulated by alpha (1A)-adrenoceptors in cardiac myocytes. Mol Pharmacol. 2004 Sep;66(3):735-48. Furthermore, the PE-sensitive current was partially inhibited by external administration of high concentrations of tetraethylammonium and 4-aminopyridine, which are voltage-gated K (+) channel-blockers. |
0(0,0,0,0) | Details |
| 14551239 | Gurney AM, Osipenko ON, MacMillan D, McFarlane KM, Tate RJ, Kempsill FE: Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. Circ Res. 2003 Nov 14;93(10):957-64. Epub 2003 Oct 9. These properties are all diagnostic of TASK-1 channels and add to previously identified features of IKN that are shared with TASK-1, such as inhibition by hypoxia, low sensitivity to 4-aminopyridine and quinine and insensitivity to tetraethylammonium ions. |
35(0,1,1,5) | Details |
| 10847588 | Czirjak G, Fischer T, Spat A, Lesage F, Enyedi P: TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II. Mol Endocrinol. 2000 Jun;14(6):863-74. In Xenopus oocytes injected with mRNA prepared from glomerulosa tissue the expressed K+ current at -100 mV was virtually insensitive to tetraethylammonium (3 mM) and 4-aminopyridine (3 mM). |
6(0,0,0,6) | Details |
| 15733086 | Larkman PM, Perkins EM: A TASK-like pH- and amine-sensitive 'leak' K+ conductance regulates neonatal rat facial motoneuron excitability in vitro. Eur J Neurosci. 2005 Feb;21(3):679-91. Ba2+, Cs+ and Rb+ blocked I (NA) and I (pH) voltage-dependently with maximal block at hyperpolarized potentials. 4-Aminopyridine (4-AP, 4 mM) voltage-independently blocked I (NA) and I (pH). |
5(0,0,0,5) | Details |
| 10725353 | Millar JA, Barratt L, Southan AP, Page KM, Fyffe RE, Robertson B, Mathie A: A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3614-8. IK (SO) is blocked by Ba (2+) ions and is regulated by activation of muscarinic M (3) receptors, but it is insensitive to the classical broad-spectrum potassium channel blocking drugs 4-aminopyridine and tetraethylammonium ions. |
5(0,0,0,5) | Details |