| Name | voltage gated K channel (protein family or complex) |
|---|---|
| Synonyms | Voltage gated K channel; Voltage gated potassium channel |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11454932 | Ceron PI, Cremonez DC, Bendhack LM, Tedesco AC: The relaxation induced by S-nitroso- and S-nitroso- in rat aorta is not related to production. J Pharmacol Exp Ther. 2001 Aug;298(2):686-94. The relaxation induced by GSNO and NACysNO was inhibited by the K+ channel blockers glibenclamide, selective K (ATP) channels, and apamin, selective for low-conductance Ca2+-activated K+ channels in rat aorta, but was not inhibited by charybdotoxin, a potent and selective Ca2+-activated K+ channel blocker, or by 4-aminopyridine, a voltage-gated K+ channel blocker. |
0(0,0,0,0) | Details |
| 17327035 | Weng ZP, Wang B, Wang SL, Cui N, Pan XY: [Influence of 4-aminopyridine on cell proliferation through inhibiting voltage-gated K+ channel in ovarian cancer]. Zhonghua Fu Chan Ke Za Zhi. 2006 Nov;41(11):762-5. |
81(1,1,1,1) | Details |
| 19134331 | Zhao ZM, Cui N, Xu SX, Gao FL, Hao GM, Cao JF: [Influence of 4-aminopyridine on human ovarian luteinized granulosa cell proliferation, production, and apoptosis through inhibiting voltage-gated K+ channel]. Zhonghua Fu Chan Ke Za Zhi. 2008 Dec;43(12):918-22. |
81(1,1,1,1) | Details |
| 14527939 | Li H, Guo W, Yamada KA, Nerbonne JM: Selective elimination of I (K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H319-28. Epub 2003 Oct 2. Although previous studies have revealed a role for the voltage-gated K+ channel alpha-subunit Kv1.5 (KCNA5) in the generation of the 4-aminopyridine (4-AP)-sensitive component of delayed rectification in mouse ventricles (IK,slow1), the phenotypic consequences of manipulating IK,slow1 expression in vivo in different (mouse) models are distinct. |
6(0,0,1,1) | Details |
| 18982871 | Gan XG, An RH, Bai YF, Zong DB: Expressions of voltage-gated K+ channel 2.1 and 2.2 in rat bladder with detrusor hyperreflexia. Chin Med J. 2008 Aug 20;121(16):1574-7. The frequency of DH in the experimental group was significantly different from that in the control group with or without treatment with 4-aminopyridine (4-AP) (P < 0.05), while the amplitude of DH did not change markedly. |
2(0,0,0,2) | Details |
| 14632936 | Chang KW, Yuan TC, Fang KP, Yang FS, Liu CJ, Chang CS, Lin SC: The increase of voltage-gated potassium channel Kv3.4 mRNA expression in oral squamous cell carcinoma. J Oral Pathol Med. 2003 Nov;32(10):606-11. METHODS: We examined the expression of an A-type voltage-gated K+ channel, Kv3.4, in oral squamous cell carcinoma (OSCC) and esophageal squamous cell carcinoma (ESCC) compared with non-cancerous matched tissue (NCMT) using RT-PCR analysis. In addition, administration of an A-type K+ channel blocker, 4-aminopyridine (4-AP), and an antisense oligodeoxynucleotide (ODN) directed specifically against Kv3.4 were performed to identify the involvement of Kv3.4 in the growth of OSCC cells. |
1(0,0,0,1) | Details |
| 12679374 | Thorneloe KS, Nelson MT: Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J Physiol. 2003 May 15;549(Pt 1):65-74. Epub 2003 Apr 4. The IK (V) was blocked by tetraethylammonium ions with an IC50 of 5.2 mM and was unaffected by 1 mM 4-aminopyridine. RT-PCR for voltage-gated K+ channel (KV) subunits revealed the expression of Kv2.1, Kv5.1, Kv6.1, Kv6.2 and Kv6.3 in isolated UBSM myocytes. |
1(0,0,0,1) | Details |
| 12838421 | Fraser SP, Grimes JA, Diss JK, Stewart D, Dolly JO, Djamgoz MB: Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation. Pflugers Arch. 2003 Aug;446(5):559-71. Epub 2003 Jul 1. Thus, the currents were blocked by 4-aminopyridine, tetraethylammonium, margatoxin, and charybdotoxin, with highly similar IC (50) s for given blockers. |
1(0,0,0,1) | Details |
| 10856117 | Korngreen A, Sakmann B: Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol. 2000 Jun 15;525 Pt 3:621-39. The results suggest that the decrease of the voltage-gated K+ channel density from the soma along the apical dendrite of L5 pyramidal neurones helps to define a distal, low threshold region for the initiation of dendritic regenerative potentials. The slow K+ current was completely blocked by tetraethylammonium (TEA) with an IC50 of 5 +/- 1 mM (mean +/- s.e.m.) and was partially blocked by 4-aminopyridine (4-AP). |
1(0,0,0,1) | Details |
| 12062371 | Belevych AE, Beck R, Tammaro P, Poston L, Smirnov SV: Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes. Cardiovasc Res. 2002 Apr;54(1):152-61. I (Kv) in neonates was insensitive to a high concentration of tetraethylammonium (TEA, 10 mM) but blocked 4-aminopyridine (4-AP, IC (50)=0.5+/-0.1 mM), whereas I (Kv) in adult RAMs was almost completely abolished by 10 mM TEA and was relatively insensitive to low concentrations of 4-AP. |
1(0,0,0,1) | Details |
| 19332619 | Wang Z, Wong NC, Cheng Y, Kehl SJ, Fedida D: Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore. J Gen Physiol. 2009 Apr;133(4):361-74. The NMDG (+) current was inhibited by extracellular 4-aminopyridine (5 mM) or tetraethylammonium (10 mM), and largely eliminated in Kv3.2b by an S6 mutation that prevents the channel from opening (P468W) and by a pore helix mutation in Kv1.5 R487Y (W472F) that inactivates the channel at rest. |
1(0,0,0,1) | Details |
| 12689856 | Lin MT, Hessinger DA, Pearce WJ, Longo LD: Developmental differences in Ca2+-activated K+ channel activity in ovine basilar artery. Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H701-9. Epub 2003 Apr 10. To test the hypothesis that these contractility differences result from maturational changes in voltage-gated K+ channel function, we compared this function in VSM myocytes from adult and fetal sheep cerebral arteries. |
1(0,0,0,1) | Details |
| 11401838 | Ekhterae D, Platoshyn O, Krick S, Yu Y, McDaniel SS, Yuan JX: Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2001 Jul;281(1):C157-65. Blockade of Kv channels in control cells (-bcl-2) by 4-aminopyridine also inhibited the ST-induced increase in I (Kv) and apoptosis. |
1(0,0,0,1) | Details |
| 10836990 | Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV: KCNA10: a novel ion channel functionally related to both voltage-gated and CNG cation channels. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21. We conclude KCNA10 is a novel human voltage-gated K channel with features common to both K-selective and CNG cation channels. The channel displays an unusual inhibitor profile because, in addition to being blocked by classical K channel blockers (barium tetraethylammonium and 4-aminopyridine), it is also sensitive to inhibitors of cyclic nucleotide-gated (CNG) cation channels and pimozide). |
1(0,0,0,1) | Details |